Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Yu Peng -- 139 2026-10-25 11:10:09 |
2 delete taxonomy path Yu Peng -12 word(s) 127 2026-10-25 11:10:22 |

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Peng, Y. Homologous Recombination. Encyclopedia. Available online: https://encyclopedia.pub/entry/61428 (accessed on 12 November 2026).
Peng Y. Homologous Recombination. Encyclopedia. Available at: https://encyclopedia.pub/entry/61428. Accessed November 12, 2026.
Peng, Yu. "Homologous Recombination" Encyclopedia, https://encyclopedia.pub/entry/61428 (accessed November 12, 2026).
Peng, Y. (2026, October 25). Homologous Recombination. In Encyclopedia. https://encyclopedia.pub/entry/61428
Peng, Yu. "Homologous Recombination." Encyclopedia. Web. 25 October, 2026.

Homologous Recombination

Edit

Homologous recombination is the exchange or copying of DNA information through pairing between molecules with related nucleotide sequences. Sequence correspondence directs a donor region toward the matching genomic target [1]. In double-strand-break repair, processing of DNA ends exposes single-stranded regions that assemble with recombination proteins, search for homology, and invade an intact duplex [2]. The paired donor provides a template for DNA synthesis, and subsequent processing restores a continuous DNA molecule. Availability of a suitable template and the state of the broken or stalled replication intermediate guide the cellular use of this pathway [3]. Cell-cycle regulation and end-processing activities coordinate homologous recombination with other repair processes. Resolution of the resulting intermediates can yield exchange of flanking DNA or localized transfer of sequence information [4][5].

DNA repair strand invasion Rad51 homology search
Help expand this entry Share your expertise by adding detailed content and references to improve this entry.
Add content

References

  1. Mario R. Capecchi; Altering the Genome by Homologous Recombination. Science 1989, 244, 1288-1292. [CrossRef]
  2. Joseph San Filippo; Patrick Sung; Hannah Klein; Mechanism of Eukaryotic Homologous Recombination. Annu. Rev. Biochem. 2008, 77, 229-257. [CrossRef]
  3. Ralph Scully; Arvind Panday; Rajula Elango; Nicholas A. Willis; DNA double-strand break repair-pathway choice in somatic mammalian cells. Nat. Rev. Mol. Cell Biol. 2019, 20, 698-714. [CrossRef]
  4. J. Ross Chapman; Martin R.G. Taylor; Simon J. Boulton; Playing the End Game: DNA Double-Strand Break Repair Pathway Choice. Mol. Cell 2012, 47, 497-510. [CrossRef]
  5. Vivek B. Raina; Aidan Jessop; Eric C. Greene; Biochemical Mechanisms of Genetic Recombination and DNA Repair. Annu. Rev. Biochem. 2025, 94, 161-193. [CrossRef]
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 7
Entry Collection: Biosynthesis and Synthetic Biology
Revisions: 2 times (View History)
Update Date: 25 Oct 2026
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Write an Entry
    Feedback