Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
+1 credit
Thank you for your contribution! You can also upload a video entry or images related to this topic.
For video creation, please contact our Academic Video Service.
Video Upload Options
We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Peng, Y. Heme-Containing Enzymes. Encyclopedia. Available online: https://encyclopedia.pub/entry/61060 (accessed on 02 November 2026).
Peng Y. Heme-Containing Enzymes. Encyclopedia. Available at: https://encyclopedia.pub/entry/61060. Accessed November 02, 2026.
Peng, Yu. "Heme-Containing Enzymes" Encyclopedia, https://encyclopedia.pub/entry/61060 (accessed November 02, 2026).
Peng, Y. (2026, October 17). Heme-Containing Enzymes. In Encyclopedia. https://encyclopedia.pub/entry/61060
Peng, Yu. "Heme-Containing Enzymes." Encyclopedia. Web. 17 October, 2026.
Copy Citation
Heme-Containing Enzymes
EditHeme-containing enzymes are enzymes that incorporate an iron–porphyrin cofactor within their catalytic machinery. Changes in iron oxidation state and coordination permit formation of reactive intermediates, including iron–oxygen species involved in substrate oxidation [1][2]. Heme-containing catalytic systems also participate in anaerobic nitrogen transformations, where c-type heme proteins mediate electron transfer and reactions involving nitrogenous substrates [3]. Binding of nitric oxide, oxygen-derived ligands, or other small molecules alters the electronic and geometric properties of the iron center [4]. The protein supplies axial ligands, substrate-binding regions, and a local environment that organizes these reactions. Heme association can also couple catalytic activity to regulatory changes in the protein [5].
heme cofactor
iron–porphyrin
oxidoreductases
oxygen activation
Help expand this entry
Share your expertise by adding detailed content and references to improve this entry.
Add content
References
- Thomas L. Poulos; Heme Enzyme Structure and Function. Chem. Rev. 2014, 114, 3919-3962. [CrossRef]
- Xiongyi Huang; John T. Groves; Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins. Chem. Rev. 2017, 118, 2491-2553. [CrossRef]
- Boran Kartal; Jan T. Keltjens; Anammox Biochemistry: a Tale of Heme c Proteins. Trends Biochem. Sci. 2016, 41, 998-1011. [CrossRef]
- Nicolai Lehnert; Eunsuk Kim; Hai T. Dong; Jill B. Harland; Andrew P. Hunt; Elizabeth C. Manickas; Kady M. Oakley; John Pham; Garrett C. Reed; Victor Sosa Alfaro; The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity. Chem. Rev. 2021, 121, 14682-14905. [CrossRef]
- Toru Shimizu; Alzbeta Lengalova; Václav Martínek; Markéta Martínková; Heme: Emergent Roles of Heme in Signal Transduction, Functional Regulation and as Catalytic Centres. Chem. Soc. Rev. 2019, 48, 5624-5657. [CrossRef]
More
Information
Subjects:
Biochemistry & Molecular Biology
Contributor
MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register
:
View Times:
7
Entry Collection:
Molecular Biology and Gene Expression Regulation
Revisions:
2 times
(View History)
Update Date:
24 Oct 2026
Table of Contents
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
Back
Comments
${ item }
|
${ item.createdUser.fullName }
${ item.createdAt }
${ item.vote }
${ item.reply }
Delete
${ reply.createdUser.fullName }
${ reply.createdAt }
${ reply.vote }
Delete
There is no reply to this comment~
${ item.replyTextCharacter }/${ item.replyMaxCharacter }
Submit
Cancel
More
No more~
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes
No