| Version | Summary | Created by | Modification | Content Size | Created at | Operation |
|---|---|---|---|---|---|---|
| 1 | Helena Kang | -- | 162 | 2026-10-12 08:02:08 |
Suzuki coupling, more precisely the Suzuki–Miyaura cross-coupling, is a palladium- or nickel-catalyzed reaction that joins an organoboron compound with an organic electrophile to form a carbon–carbon bond. Typical partners are aryl, vinyl, or alkyl boronic acids, boronate esters, or organotrifluoroborates and aryl or vinyl halides or pseudohalides. The catalytic sequence comprises oxidative addition of the electrophile to a low-valent metal, base-assisted activation and transmetalation of the carbon group from boron, and reductive elimination of the coupled product [1]. The base converts the organoboron reagent or metal-bound ligand sphere into a form competent for transfer, but it is not itself the coupling catalyst. The defining distinction from Stille coupling is use of organoboron rather than organotin reagents, and from Heck coupling is transfer of a discrete carbon group rather than migratory insertion of an alkene. The reaction accommodates stereodefined alkenyl partners and commonly preserves their alkene geometry [2].