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Kang, H. Microprobe Mass Spectrometry. Encyclopedia. Available online: https://encyclopedia.pub/entry/60723 (accessed on 12 November 2026).
Kang H. Microprobe Mass Spectrometry. Encyclopedia. Available at: https://encyclopedia.pub/entry/60723. Accessed November 12, 2026.
Kang, Helena. "Microprobe Mass Spectrometry" Encyclopedia, https://encyclopedia.pub/entry/60723 (accessed November 12, 2026).
Kang, H. (2026, October 09). Microprobe Mass Spectrometry. In Encyclopedia. https://encyclopedia.pub/entry/60723
Kang, Helena. "Microprobe Mass Spectrometry." Encyclopedia. Web. 09 October, 2026.

Microprobe Mass Spectrometry

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A spatially confined ionization probe that samples a microscopic volume, followed by mass analysis of the ejected ions, constitutes microprobe mass spectrometry. The probe may be a focused laser (laser microprobe mass spectrometry), a focused primary-ion beam (ion microprobe mass spectrometry), or a related localized source; the spectrum is registered to a selected spot on the specimen [1]. Ion microprobe analysis of particle surfaces demonstrates that localized sputtering and mass analysis preserve spatially confined elemental information [2]. Conceptual boundaries exclude bulk mass spectrometry of homogenized samples and optical or electron microprobes that do not record mass-to-charge ratios. Essential features are a probe whose interaction volume is small relative to the specimen, a viewing or scanning system that defines the coordinates, and a mass analyzer synchronized to the probe [3]. Laser microprobe implementations (LAMMA) are the photon-probe member of this class and share the spatial-sampling definition while differing in the ionization physics from ion-beam microprobes [4].

microprobe mass spectrometry localized ionization ion microprobe spatial sampling
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References

  1. Luc VAN Vaeck; Katrien Poels; Sonja DE Nollin; Adam Hachimi; Renaat Gijbels; Laser microprobe mass spectrometry: principle and applications in biology and medicine. Cell Biol. Int. 1997, 21, 635-648. [CrossRef]
  2. R W Linton; P Williams; C A Evans; D F Natusch; Determination of the surface predominance of toxic elements in airborne particles by ion microprobe mass spectrometry and Auger electron spectrometry. Anal. Chem. 1977, 49, 1514-1521. [CrossRef]
  3. Jan Claereboudt; Magda Claeys; Herman Geise; Renaat Gijbels; Akos Vertes; Laser microprobe mass spectrometry of quaternary phosphonium salts: Direct versus matrix-assisted laser desorption. J. Am. Soc. Mass Spectrom. 1993, 4, 798-812. [CrossRef]
  4. J. Claereboudt; B. de Spiegeleer; E.A. de Bruijn; R. Gijbels; M. Claeys; Structural characterization of cisplatin analogues by fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA). J. Pharm. Biomed. Anal. 1989, 7, 1599-1610. [CrossRef]
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Subjects: Chemistry, Analytical
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Helena Kang
View Times: 16
Entry Collection: Analytical Chemistry
Revisions: 3 times (View History)
Update Date: 21 Oct 2026
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