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Kang, H. Laser Microprobe Mass Spectrometry. Encyclopedia. Available online: https://encyclopedia.pub/entry/60715 (accessed on 12 November 2026).
Kang H. Laser Microprobe Mass Spectrometry. Encyclopedia. Available at: https://encyclopedia.pub/entry/60715. Accessed November 12, 2026.
Kang, Helena. "Laser Microprobe Mass Spectrometry" Encyclopedia, https://encyclopedia.pub/entry/60715 (accessed November 12, 2026).
Kang, H. (2026, October 09). Laser Microprobe Mass Spectrometry. In Encyclopedia. https://encyclopedia.pub/entry/60715
Kang, Helena. "Laser Microprobe Mass Spectrometry." Encyclopedia. Web. 09 October, 2026.

Laser Microprobe Mass Spectrometry

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A focused laser that ablates a micrometre-scale spot, coupled to a time-of-flight or related mass analyzer, defines laser microprobe mass spectrometry (LMMS, historically LAMMA). The microprobe geometry localizes the desorption and ionization event so that elemental and molecular ions from a selected microscopic volume are recorded [1]. Direct laser desorption from the neat solid may be compared with matrix-assisted desorption from the same microprobe, which changes the ion yield and fragmentation but not the spatial-probe definition [2]. Conceptual boundaries exclude bulk laser-desorption mass spectrometry without spatial selection, secondary-ion microprobes that use an ion beam, and optical laser microprobes that do not mass-analyze the ejecta. Essential features are a diffraction-limited or otherwise focused laser, a viewing system that registers the sampled spot, and a mass analyzer synchronized to the laser pulse [3]. Inorganic deposits and organometallic drugs in tissue have been identified by the same localized ionization, which underscores that the defining object is the microprobe-sampled mass spectrum [4].

laser microprobe LAMMA spatially localized ionization time-of-flight
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References

  1. Luc VAN Vaeck; Katrien Poels; Sonja DE Nollin; Adam Hachimi; Renaat Gijbels; Laser microprobe mass spectrometry: principle and applications in biology and medicine. Cell Biol. Int. 1997, 21, 635-648. [CrossRef]
  2. Jan Claereboudt; Magda Claeys; Herman Geise; Renaat Gijbels; Akos Vertes; Laser microprobe mass spectrometry of quaternary phosphonium salts: Direct versus matrix-assisted laser desorption. J. Am. Soc. Mass Spectrom. 1993, 4, 798-812. [CrossRef]
  3. J. Claereboudt; B. de Spiegeleer; E.A. de Bruijn; R. Gijbels; M. Claeys; Structural characterization of cisplatin analogues by fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA). J. Pharm. Biomed. Anal. 1989, 7, 1599-1610. [CrossRef]
  4. A. H. Verbueken; R. E. Van Grieken; G. J. Paulus; G. A. Verpooten; M. E. De Broe; Laser microprobe mass spectrometry of platinum in dog kidney after cisplatin adminstration. J. Mass Spectrom. 1984, 11, 159-163. [CrossRef]
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Subjects: Chemistry, Analytical
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Helena Kang
View Times: 16
Entry Collection: Analytical Chemistry
Revisions: 3 times (View History)
Update Date: 21 Oct 2026
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