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Kang, H. Ion Chromatography. Encyclopedia. Available online: https://encyclopedia.pub/entry/60708 (accessed on 12 November 2026).
Kang H. Ion Chromatography. Encyclopedia. Available at: https://encyclopedia.pub/entry/60708. Accessed November 12, 2026.
Kang, Helena. "Ion Chromatography" Encyclopedia, https://encyclopedia.pub/entry/60708 (accessed November 12, 2026).
Kang, H. (2026, October 09). Ion Chromatography. In Encyclopedia. https://encyclopedia.pub/entry/60708
Kang, Helena. "Ion Chromatography." Encyclopedia. Web. 09 October, 2026.

Ion Chromatography

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High-performance ion-exchange separation of small inorganic and organic ions, usually with suppressed or non-suppressed conductivity detection, constitutes ion chromatography (IC) in analytical chemistry. A low-capacity ion-exchange column is eluted with a dilute aqueous eluent; after chemical or electrolytic suppression of the eluent’s background conductivity, the analyte ions are recorded as conductivity peaks, although UV, amperometric, or mass-spectrometric detection may be used instead [1]. Combustion ion chromatography converts organically bound fluorine or other heteroatoms to inorganic ions before the chromatographic step, which is still IC of those ions [2]. Conceptual boundaries exclude gas-phase ion mobility sometimes also called ion chromatography, and they exclude general ion-exchange chromatography of proteins that is not configured as high-performance IC of small ions. Essential features are an ion-exchange separator, an eluent whose strength is matched to monovalent and divalent ions, and a detection scheme that reports ionic equivalents. Silver-ion chromatography of lipids is a related but distinct complexation mode and is not IC in the suppressed-conductivity sense [3].

ion chromatography conductivity detection ion exchange inorganic ions
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References

  1. Lorne R. Goodwin; Donna Francom; Fred P. Dieken; Jack D. Taylor; Marcus W. Warenycia; R. J. Reiffenstein; Graeme Dowling; Determination of Sulfide in Brain Tissue by Gas Dialysis/Ion Chromatography: Postmortem Studies and Two Case Reports. J. Anal. Toxicol. 1989, 13, 105-109. [CrossRef]
  2. Yuichi Miyake; Nobuyoshi Yamashita; Pawel Rostkowski; Man Ka So; Sachi Taniyasu; Paul K.S. Lam; Kurunthachalam Kannan; Determination of trace levels of total fluorine in water using combustion ion chromatography for fluorine: A mass balance approach to determine individual perfluorinated chemicals in water. J. Chromatogr. A 2007, 1143, 98-104. [CrossRef]
  3. L.J. Morris; Separations of lipids by silver ion chromatography. J. Lipid Res. 1966, 7, 717-732. [CrossRef]
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Entry Collection: Analytical Chemistry
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Update Date: 21 Oct 2026
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