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Tang, P. HANAC. Encyclopedia. Available online: https://encyclopedia.pub/entry/6049 (accessed on 20 September 2026).
Tang P. HANAC. Encyclopedia. Available at: https://encyclopedia.pub/entry/6049. Accessed September 20, 2026.
Tang, Peter. "HANAC" Encyclopedia, https://encyclopedia.pub/entry/6049 (accessed September 20, 2026).
Tang, P. (2021, January 04). HANAC. In Encyclopedia. https://encyclopedia.pub/entry/6049
Tang, Peter. "HANAC." Encyclopedia. Web. 04 January, 2021.
HANAC
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/hereditary-angiopathy-with-nephropathy-aneurysms-and-muscle-cramps-syndrome

Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) syndrome is part of a group of conditions called the COL4A1-related disorders. The conditions in this group have a range of signs and symptoms that involve fragile blood vessels. HANAC syndrome is characterized by angiopathy, which is a disorder of the blood vessels. In people with HANAC syndrome, angiopathy affects several parts of the body. The blood vessels as well as thin sheet-like structures called basement membranes that separate and support cells are weakened and more susceptible to breakage.

genetic conditions

References

  1. Alamowitch S, Plaisier E, Favrole P, Prost C, Chen Z, Van Agtmael T, Marro B, Ronco P. Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome.Neurology. 2009 Dec 1;73(22):1873-82. doi: 10.1212/WNL.0b013e3181c3fd12.
  2. Plaisier E, Chen Z, Gekeler F, Benhassine S, Dahan K, Marro B, Alamowitch S,Paques M, Ronco P. Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain. Am J Med Genet A. 2010Oct;152A(10):2550-5. doi: 10.1002/ajmg.a.33659.
  3. Vahedi K, Alamowitch S. Clinical spectrum of type IV collagen (COL4A1)mutations: a novel genetic multisystem disease. Curr Opin Neurol. 2011Feb;24(1):63-8. doi: 10.1097/WCO.0b013e32834232c6. Review.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
View Times: 1.5K
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 04 Jan 2021
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