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Kang, H. Organosulfur Synthesis. Encyclopedia. Available online: https://encyclopedia.pub/entry/60372 (accessed on 03 October 2026).
Kang H. Organosulfur Synthesis. Encyclopedia. Available at: https://encyclopedia.pub/entry/60372. Accessed October 03, 2026.
Kang, Helena. "Organosulfur Synthesis" Encyclopedia, https://encyclopedia.pub/entry/60372 (accessed October 03, 2026).
Kang, H. (2026, September 23). Organosulfur Synthesis. In Encyclopedia. https://encyclopedia.pub/entry/60372
Kang, Helena. "Organosulfur Synthesis." Encyclopedia. Web. 23 September, 2026.
Organosulfur Synthesis
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Organosulfur synthesis comprises bond-forming and functional-group interconversion methods that produce organic compounds containing carbon–sulfur bonds or transform one organosulfur class into another. The concept is bounded by sulfur attached to an organic framework and excludes purely inorganic sulfur chemistry. Its defining reactivity follows sulfur across several oxidation states, including thiols, sulfides, disulfides, sulfoxides, sulfones, sulfonium salts, sulfur ylides, sulfinates, and sulfonates. Nucleophilic substitution by sulfur anions, electrophilic sulfur transfer, radical addition, and metal-catalyzed C–S coupling are principal bond-forming modes. Reactions at sulfur(IV) can change both oxidation state and connectivity through sulfoxide activation, sulfonium formation, ylide chemistry, and sulfinate conversion [1]. Sulfur-transfer reagents provide complementary routes in which a defined sulfur unit is delivered to an organic substrate [2]. The field is distinguished from organoselenium and organophosphorus synthesis by sulfur's characteristic oxidation-state ladder, nucleophilicity, and leaving-group behavior.

organosulfur compound C–S bond formation sulfur oxidation state nucleophilic substitution

References

  1. Daniel Kaiser; Immo Klose; Rik Oost; James Neuhaus; Nuno Maulide; Bond-Forming and -Breaking Reactions at Sulfur(IV): Sulfoxides, Sulfonium Salts, Sulfur Ylides, and Sulfinate Salts. Chem. Rev. 2019, 119, 8701-8780. [CrossRef]
  2. Hui Liu; Xuefeng Jiang; Transfer of Sulfur: From Simple to Diverse. Chem. – Asian J. 2013, 8, 2546-2563. [CrossRef]
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Subjects: Chemistry, Organic
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Helena Kang
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Update Date: 23 Sep 2026
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