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Tang, P. CBF-AML. Encyclopedia. Available online: https://encyclopedia.pub/entry/6035 (accessed on 20 September 2026).
Tang P. CBF-AML. Encyclopedia. Available at: https://encyclopedia.pub/entry/6035. Accessed September 20, 2026.
Tang, Peter. "CBF-AML" Encyclopedia, https://encyclopedia.pub/entry/6035 (accessed September 20, 2026).
Tang, P. (2021, January 04). CBF-AML. In Encyclopedia. https://encyclopedia.pub/entry/6035
Tang, Peter. "CBF-AML." Encyclopedia. Web. 04 January, 2021.
CBF-AML
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/core-binding-factor-acute-myeloid-leukemia

Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.

genetic conditions

References

  1. Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia:current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133.doi: 10.1007/s12185-011-0858-z.
  2. Kuykendall A, Duployez N, Boissel N, Lancet JE, Welch JS. Acute MyeloidLeukemia: The Good, the Bad, and the Ugly. Am Soc Clin Oncol Educ Book. 2018 May 23;38:555-573. doi: 10.1200/EDBK_199519. Review.
  3. Lam K, Zhang DE. RUNX1 and RUNX1-ETO: roles in hematopoiesis andleukemogenesis. Front Biosci (Landmark Ed). 2012 Jan 1;17:1120-39. Review.
  4. Marcucci G, Haferlach T, Döhner H. Molecular genetics of adult acute myeloidleukemia: prognostic and therapeutic implications. J Clin Oncol. 2011 Feb10;29(5):475-86. doi: 10.1200/JCO.2010.30.2554.in: J Clin Oncol. 2011 May 1;29(13):1798.
  5. Paschka P, Döhner K. Core-binding factor acute myeloid leukemia: can weimprove on HiDAC consolidation? Hematology Am Soc Hematol Educ Program.2013;2013:209-19. doi: 10.1182/asheducation-2013.1.209. Review.
  6. Sangle NA, Perkins SL. Core-binding factor acute myeloid leukemia. Arch PatholLab Med. 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. Review.
  7. Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD,Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, WallisJW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L,O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD,Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, WylieTN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, PaytonJE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, DiPersio JF, Ding L, Mardis ER, Wilson RK. The origin and evolution ofmutations in acute myeloid leukemia. Cell. 2012 Jul 20;150(2):264-78. doi:10.1016/j.cell.2012.06.023.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Entry Collection: MedlinePlus
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Update Date: 04 Jan 2021
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