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Tang, P. LEP Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/6001 (accessed on 20 September 2026).
Tang P. LEP Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/6001. Accessed September 20, 2026.
Tang, Peter. "LEP Gene" Encyclopedia, https://encyclopedia.pub/entry/6001 (accessed September 20, 2026).
Tang, P. (2021, January 04). LEP Gene. In Encyclopedia. https://encyclopedia.pub/entry/6001
Tang, Peter. "LEP Gene." Encyclopedia. Web. 04 January, 2021.
LEP Gene
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/lep

leptin

genes

References

  1. Dubern B, Clement K. Leptin and leptin receptor-related monogenic obesity.Biochimie. 2012 Oct;94(10):2111-5. doi: 10.1016/j.biochi.2012.05.010. Epub 2012May 22. Review. Citation on PubMed
  2. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O'Rahilly S. Effects of recombinant leptin therapy in a childwith congenital leptin deficiency. N Engl J Med. 1999 Sep 16;341(12):879-84. Citation on PubMed
  3. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, JebbSA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S. Beneficial effectsof leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolicdysfunction of human congenital leptin deficiency. J Clin Invest. 2002Oct;110(8):1093-103. Citation on PubMed or Free article on PubMed Central
  4. Fatima W, Shahid A, Imran M, Manzoor J, Hasnain S, Rana S, Mahmood S. Leptindeficiency and leptin gene mutations in obese children from Pakistan. Int JPediatr Obes. 2011 Oct;6(5-6):419-27. doi: 10.3109/17477166.2011.608431. Epub2011 Aug 19. Citation on PubMed
  5. Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O'Rahilly S, TrussellRA. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptintherapy. J Clin Endocrinol Metab. 2004 Oct;89(10):4821-6. Citation on PubMed
  6. Mazen I, El-Gammal M, Abdel-Hamid M, Amr K. A novel homozygous missensemutation of the leptin gene (N103K) in an obese Egyptian patient. Mol GenetMetab. 2009 Aug;97(4):305-8. doi: 10.1016/j.ymgme.2009.04.002. Epub 2009 Apr 9. Citation on PubMed
  7. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB,O'Rahilly S. Congenital leptin deficiency is associated with severe early-onsetobesity in humans. Nature. 1997 Jun 26;387(6636):903-8. Citation on PubMed
  8. O'Rahilly S. Leptin: defining its role in humans by the clinical study ofgenetic disorders. Nutr Rev. 2002 Oct;60(10 Pt 2):S30-4; discussion S68-84, 85-7.Review. Citation on PubMed
  9. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missensemutation: multiple endocrine defects, decreased sympathetic tone, and immunesystem dysfunction indicate new targets for leptin action, greater central thanperipheral resistance to the effects of leptin, and spontaneous correction ofleptin-mediated defects. J Clin Endocrinol Metab. 1999 Oct;84(10):3686-95.Erratum in: J Clin Endocrinol Metab 2000 Jan;85(1):416. Citation on PubMed
  10. Saeed S, Butt TA, Anwer M, Arslan M, Froguel P. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity fromPakistani consanguineous families. Mol Genet Metab. 2012 May;106(1):121-6. doi:10.1016/j.ymgme.2012.03.001. Epub 2012 Mar 10. Erratum in: Mol Genet Metab. 2013 Aug;109(4):404. Citation on PubMed
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Subjects: Genetics & Heredity
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Update Date: 04 Jan 2021
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