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Tang, P. Restless Legs Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/5983 (accessed on 20 September 2026).
Tang P. Restless Legs Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/5983. Accessed September 20, 2026.
Tang, Peter. "Restless Legs Syndrome" Encyclopedia, https://encyclopedia.pub/entry/5983 (accessed September 20, 2026).
Tang, P. (2021, January 04). Restless Legs Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/5983
Tang, Peter. "Restless Legs Syndrome." Encyclopedia. Web. 04 January, 2021.
Restless Legs Syndrome
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/restless-legs-syndrome

Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

genetic conditions

References

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  2. Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, Ripke S,Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W,Högl B, Frauscher B, Gschliesser V, Poewe W, Peglau I, Vodicka P, Vávrová J,Sonka K, Nevsimalova S, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T,Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T, Winkelmann J. PTPRD(protein tyrosine phosphatase receptor type delta) is associated with restlesslegs syndrome. Nat Genet. 2008 Aug;40(8):946-8. doi: 10.1038/ng.190. Epub 2008Jul 27. Citation on PubMed
  3. Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, Dauvilliers Y,Stefani A, Högl B, Poewe W, Kemlink D, Sonka K, Bachmann CG, Paulus W,Trenkwalder C, Oertel WH, Hornyak M, Teder-Laving M, Metspalu A, HadjigeorgiouGM, Polo O, Fietze I, Ross OA, Wszolek Z, Butterworth AS, Soranzo N, Ouwehand WH,Roberts DJ, Danesh J, Allen RP, Earley CJ, Ondo WG, Xiong L, Montplaisir J,Gan-Or Z, Perola M, Vodicka P, Dina C, Franke A, Tittmann L, Stewart AFR, ShahSH, Gieger C, Peters A, Rouleau GA, Berger K, Oexle K, Di Angelantonio E, HindsDA, Müller-Myhsok B, Winkelmann J; 23andMe Research Team; DESIR study group.Identification of novel risk loci for restless legs syndrome in genome-wideassociation studies in individuals of European ancestry: a meta-analysis. Lancet Neurol. 2017 Nov;16(11):898-907. doi: 10.1016/S1474-4422(17)30327-7. Review. Citation on PubMed or Free article on PubMed Central
  4. Tim RW, Sanders DB. Repetitive nerve stimulation studies in the Lambert-Eaton myasthenic syndrome. Muscle Nerve. 1994 Sep;17(9):995-1001. Citation on PubMed
  5. Trenkwalder C, Paulus W. Restless legs syndrome: pathophysiology, clinicalpresentation and management. Nat Rev Neurol. 2010 Jun;6(6):337-46. doi:10.1038/nrneurol.2010.55. Review. Citation on PubMed
  6. Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C,Dauvilliers Y, Polo O, Högl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K,Oertel W, Bachmann CG, Paulus W, Xiong L, Montplaisir J, Rouleau GA, Fietze I,Vávrová J, Kemlink D, Sonka K, Nevsimalova S, Lin SC, Wszolek Z, Vilariño-GüellC, Farrer MJ, Gschliesser V, Frauscher B, Falkenstetter T, Poewe W, Allen RP,Earley CJ, Ondo WG, Le WD, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Prokisch H, Lichtner P, Peppard P, Faraco J, Mignot E, Gieger C, Illig T,Wichmann HE, Müller-Myhsok B, Meitinger T. Genome-wide association studyidentifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet. 2011 Jul;7(7):e1002171. doi: 10.1371/journal.pgen.1002171. Epub 2011 Jul 14. Erratum in: PLoS Genet. 2011 Aug;7(8). doi:10.1371/annotation/393ad2d3-df4f-4770-87bc-00bfabf79362. Citation on PubMed or Free article on PubMed Central
  7. Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, FuldaS, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K,Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G,Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, MeitingerT. Genome-wide association study of restless legs syndrome identifies commonvariants in three genomic regions. Nat Genet. 2007 Aug;39(8):1000-6. Epub 2007Jul 18. Citation on PubMed
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  10. Yang Q, Li L, Chen Q, Foldvary-Schaefer N, Ondo WG, Wang QK. Associationstudies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndromein a US population. Sleep Med. 2011 Sep;12(8):800-4. doi:10.1016/j.sleep.2011.06.006. Citation on PubMed or Free article on PubMed Central
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Entry Collection: MedlinePlus
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Update Date: 04 Jan 2021
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