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Tang, P. Primary Spontaneous Pneumothorax. Encyclopedia. Available online: https://encyclopedia.pub/entry/5981 (accessed on 20 September 2026).
Tang P. Primary Spontaneous Pneumothorax. Encyclopedia. Available at: https://encyclopedia.pub/entry/5981. Accessed September 20, 2026.
Tang, Peter. "Primary Spontaneous Pneumothorax" Encyclopedia, https://encyclopedia.pub/entry/5981 (accessed September 20, 2026).
Tang, P. (2021, January 04). Primary Spontaneous Pneumothorax. In Encyclopedia. https://encyclopedia.pub/entry/5981
Tang, Peter. "Primary Spontaneous Pneumothorax." Encyclopedia. Web. 04 January, 2021.
Primary Spontaneous Pneumothorax
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/primary-spontaneous-pneumothorax

Primary spontaneous pneumothorax is an abnormal accumulation of air in the space between the lungs and the chest cavity (called the pleural space) that can result in the partial or complete collapse of a lung. This type of pneumothorax is described as primary because it occurs in the absence of lung disease such as emphysema. Spontaneous means the pneumothorax was not caused by an injury such as a rib fracture. Primary spontaneous pneumothorax is likely due to the formation of small sacs of air (blebs) in lung tissue that rupture, causing air to leak into the pleural space. Air in the pleural space creates pressure on the lung and can lead to its collapse. A person with this condition may feel chest pain on the side of the collapsed lung and shortness of breath.

genetic conditions

References

  1. Bintcliffe O, Maskell N. Spontaneous pneumothorax. BMJ. 2014 May 8;348:g2928. doi: 10.1136/bmj.g2928. Review. Citation on PubMed
  2. Chiu HT, Garcia CK. Familial spontaneous pneumothorax. Curr Opin Pulm Med.2006 Jul;12(4):268-72. Review. Citation on PubMed
  3. Fröhlich BA, Zeitz C, Mátyás G, Alkadhi H, Tuor C, Berger W, Russi EW. Novelmutations in the folliculin gene associated with spontaneous pneumothorax. EurRespir J. 2008 Nov;32(5):1316-20. doi: 10.1183/09031936.00132707. Epub 2008 Jun25. Citation on PubMed
  4. Painter JN, Tapanainen H, Somer M, Tukiainen P, Aittomäki K. A 4-bp deletionin the Birt-Hogg-Dubé gene (FLCN) causes dominantly inherited spontaneouspneumothorax. Am J Hum Genet. 2005 Mar;76(3):522-7. Epub 2005 Jan 18. Citation on PubMed or Free article on PubMed Central
  5. Ren HZ, Zhu CC, Yang C, Chen SL, Xie J, Hou YY, Xu ZF, Wang DJ, Mu DK, Ma DH, Wang Y, Ye MH, Ye ZR, Chen BF, Wang CG, Lin J, Qiao D, Yi L. Mutation analysis ofthe FLCN gene in Chinese patients with sporadic and familial isolated primaryspontaneous pneumothorax. Clin Genet. 2008 Aug;74(2):178-83. doi:10.1111/j.1399-0004.2008.01030.x. Epub 2008 May 25. Citation on PubMed
  6. Sundaram S, Tasker AD, Morrell NW. Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation. Eur Respir J. 2009 Jun;33(6):1510-2. doi: 10.1183/09031936.00062608. Citation on PubMed
  7. Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, KrasnikM, Maskell N, Van Schil P, Tonia T, Waller DA, Marquette CH, Cardillo G. ERS taskforce statement: diagnosis and treatment of primary spontaneous pneumothorax. EurRespir J. 2015 Aug;46(2):321-35. doi: 10.1183/09031936.00219214. Epub 2015 Jun25. Review. Citation on PubMed
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
View Times: 841
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 04 Jan 2021
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