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Tang, P. Primary Myelofibrosis. Encyclopedia. Available online: https://encyclopedia.pub/entry/5980 (accessed on 20 September 2026).
Tang P. Primary Myelofibrosis. Encyclopedia. Available at: https://encyclopedia.pub/entry/5980. Accessed September 20, 2026.
Tang, Peter. "Primary Myelofibrosis" Encyclopedia, https://encyclopedia.pub/entry/5980 (accessed September 20, 2026).
Tang, P. (2021, January 04). Primary Myelofibrosis. In Encyclopedia. https://encyclopedia.pub/entry/5980
Tang, Peter. "Primary Myelofibrosis." Encyclopedia. Web. 04 January, 2021.
Primary Myelofibrosis
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/primary-myelofibrosis

Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. Because of the fibrosis, the bone marrow is unable to make enough normal blood cells. The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis.

genetic conditions

References

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  2. Ciurea SO, Merchant D, Mahmud N, Ishii T, Zhao Y, Hu W, Bruno E, Barosi G, Xu M, Hoffman R. Pivotal contributions of megakaryocytes to the biology ofidiopathic myelofibrosis. Blood. 2007 Aug 1;110(3):986-93. Epub 2007 May 1. Citation on PubMed or Free article on PubMed Central
  3. Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD,Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K,Milanesi C, Casetti IC, Sant'Antonio E, Ferretti V, Elena C, Schischlik F, ClearyC, Six M, Schalling M, Schönegger A, Bock C, Malcovati L, Pascutto C,Superti-Furga G, Cazzola M, Kralovics R. Somatic mutations of calreticulin inmyeloproliferative neoplasms. N Engl J Med. 2013 Dec 19;369(25):2379-90. doi:10.1056/NEJMoa1311347. Epub 2013 Dec 10. Citation on PubMed
  4. Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J,Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P,Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT,Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O'Meara S,McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M,Bowen D, Huntly BJP, Harrison CN, Cross NCP, Ron D, Vannucchi AM, Papaemmanuil E,Campbell PJ, Green AR. Somatic CALR mutations in myeloproliferative neoplasmswith nonmutated JAK2. N Engl J Med. 2013 Dec 19;369(25):2391-2405. doi:10.1056/NEJMoa1312542. Epub 2013 Dec 10. Citation on PubMed or Free article on PubMed Central
  5. Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, DeAngelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M,Gilliland DG, Levine RL. MPLW515L is a novel somatic activating mutation inmyelofibrosis with myeloid metaplasia. PLoS Med. 2006 Jul;3(7):e270. Citation on PubMed or Free article on PubMed Central
  6. Saint-Martin C, Leroy G, Delhommeau F, Panelatti G, Dupont S, James C, Plo I, Bordessoule D, Chomienne C, Delannoy A, Devidas A, Gardembas-Pain M, Isnard F,Plumelle Y, Bernard O, Vainchenker W, Najman A, Bellanné-Chantelot C; FrenchGroup of Familial Myeloproliferative Disorders. Analysis of the ten-eleventranslocation 2 (TET2) gene in familial myeloproliferative neoplasms. Blood. 2009Aug 20;114(8):1628-32. doi: 10.1182/blood-2009-01-197525. Epub 2009 Jun 29. Citation on PubMed
  7. Tefferi A, Pardanani A, Lim KH, Abdel-Wahab O, Lasho TL, Patel J, Gangat N,Finke CM, Schwager S, Mullally A, Li CY, Hanson CA, Mesa R, Bernard O, DelhommeauF, Vainchenker W, Gilliland DG, Levine RL. TET2 mutations and their clinicalcorrelates in polycythemia vera, essential thrombocythemia and myelofibrosis.Leukemia. 2009 May;23(5):905-11. doi: 10.1038/leu.2009.47. Epub 2009 Mar 5. Citation on PubMed or Free article on PubMed Central
  8. Tefferi A. Novel mutations and their functional and clinical relevance inmyeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1.Leukemia. 2010 Jun;24(6):1128-38. doi: 10.1038/leu.2010.69. Epub 2010 Apr 29.Review. Citation on PubMed or Free article on PubMed Central
  9. Tefferi A. Pathogenesis of myelofibrosis with myeloid metaplasia. J ClinOncol. 2005 Nov 20;23(33):8520-30. Review. Citation on PubMed
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Update Date: 04 Jan 2021
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