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Tang, P. Non-alcoholic Fatty Liver Disease. Encyclopedia. Available online: https://encyclopedia.pub/entry/5975 (accessed on 25 September 2026).
Tang P. Non-alcoholic Fatty Liver Disease. Encyclopedia. Available at: https://encyclopedia.pub/entry/5975. Accessed September 25, 2026.
Tang, Peter. "Non-alcoholic Fatty Liver Disease" Encyclopedia, https://encyclopedia.pub/entry/5975 (accessed September 25, 2026).
Tang, P. (2021, January 04). Non-alcoholic Fatty Liver Disease. In Encyclopedia. https://encyclopedia.pub/entry/5975
Tang, Peter. "Non-alcoholic Fatty Liver Disease." Encyclopedia. Web. 04 January, 2021.
Non-alcoholic Fatty Liver Disease
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/non-alcoholic-fatty-liver-disease

Non-alcoholic fatty liver disease (NAFLD) is a buildup of excessive fat in the liver that can lead to liver damage resembling the damage caused by alcohol abuse, but that occurs in people who do not drink heavily. The liver is a part of the digestive system that helps break down food, store energy, and remove waste products, including toxins. The liver normally contains some fat; an individual is considered to have a fatty liver (hepatic steatosis) if the liver contains more than 5 to 10 percent fat.

genetic conditions

References

  1. Caligiuri A, Gentilini A, Marra F. Molecular Pathogenesis of NASH. Int J MolSci. 2016 Sep 20;17(9). pii: E1575. Review. Citation on PubMed or Free article on PubMed Central
  2. Chen LZ, Xin YN, Geng N, Jiang M, Zhang DD, Xuan SY. PNPLA3 I148M variant innonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. World J Gastroenterol. 2015 Jan 21;21(3):794-802. doi: 10.3748/wjg.v21.i3.794. Review. Citation on PubMed or Free article on PubMed Central
  3. Dongiovanni P, Donati B, Fares R, Lombardi R, Mancina RM, Romeo S, Valenti L. PNPLA3 I148M polymorphism and progressive liver disease. World J Gastroenterol.2013 Nov 7;19(41):6969-78. doi: 10.3748/wjg.v19.i41.6969. Review. Citation on PubMed or Free article on PubMed Central
  4. Gu J, Yao M, Yao D, Wang L, Yang X, Yao D. Nonalcoholic Lipid Accumulation andHepatocyte Malignant Transformation. J Clin Transl Hepatol. 2016 Jun28;4(2):123-30. doi: 10.14218/JCTH.2016.00010. Epub 2016 Jun 15. Review. Citation on PubMed or Free article on PubMed Central
  5. Kahali B, Halligan B, Speliotes EK. Insights from Genome-Wide AssociationAnalyses of Nonalcoholic Fatty Liver Disease. Semin Liver Dis. 2015Nov;35(4):375-91. doi: 10.1055/s-0035-1567870. Epub 2015 Dec 16. Review. Citation on PubMed or Free article on PubMed Central
  6. Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, Ochi H,Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K.Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liverdisease and metabolic syndrome traits. Endocr J. 2014;61(7):683-9. Epub 2014 May 1. Citation on PubMed
  7. Krawczyk M, Portincasa P, Lammert F. PNPLA3-associated steatohepatitis: towarda gene-based classification of fatty liver disease. Semin Liver Dis. 2013Nov;33(4):369-79. doi: 10.1055/s-0033-1358525. Epub 2013 Nov 12. Review. Citation on PubMed
  8. Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, Borén J,Montalcini T, Pujia A, Wiklund O, Hindy G, Spagnuolo R, Motta BM, Pipitone RM,Craxì A, Fargion S, Nobili V, Käkelä P, Kärjä V, Männistö V, Pihlajamäki J,Reilly DF, Castro-Perez J, Kozlitina J, Valenti L, Romeo S. The MBOAT7-TMC4Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease inIndividuals of European Descent. Gastroenterology. 2016 May;150(5):1219-1230.e6. doi: 10.1053/j.gastro.2016.01.032. Epub 2016 Feb 2. Citation on PubMed or Free article on PubMed Central
  9. Severson TJ, Besur S, Bonkovsky HL. Genetic factors that affect nonalcoholicfatty liver disease: A systematic clinical review. World J Gastroenterol. 2016Aug 7;22(29):6742-56. doi: 10.3748/wjg.v22.i29.6742. Review. Citation on PubMed or Free article on PubMed Central
  10. Yu J, Marsh S, Hu J, Feng W, Wu C. The Pathogenesis of Nonalcoholic FattyLiver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background.Gastroenterol Res Pract. 2016;2016:2862173. doi: 10.1155/2016/2862173. Epub 2016 May 9. Review. Citation on PubMed or Free article on PubMed Central
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Update Date: 04 Jan 2021
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