Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Peter Tang + 497 word(s) 497 2020-12-30 02:34:00

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Tang, P. Lynch Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/5972 (accessed on 26 September 2026).
Tang P. Lynch Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/5972. Accessed September 26, 2026.
Tang, Peter. "Lynch Syndrome" Encyclopedia, https://encyclopedia.pub/entry/5972 (accessed September 26, 2026).
Tang, P. (2021, January 04). Lynch Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/5972
Tang, Peter. "Lynch Syndrome." Encyclopedia. Web. 04 January, 2021.
Lynch Syndrome
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/lynch-syndrome

Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer.

genetic conditions

References

  1. Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP,Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, BalaguerF, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen CappelWH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A,Lopez-Köstner F, Gluck N, Katz LH, Heinimann K, Vaccaro CA, Büttner R, Görgens H,Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, Knebel Doeberitz MV, LoefflerM, Rahner N, Schackert HK, Steinke-Lange V, Schmiegel W, Vangala D, PylvänäinenK, Renkonen-Sinisalo L, Hopper JL, Win AK, Haile RW, Lindor NM, Gallinger S, LeMarchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Wadt K, Therkildsen C,Okkels H, Ketabi Z, Moreira L, Sánchez A, Serra-Burriel M, Pineda M, Navarro M,Blanco I, Green K, Lalloo F, Crosbie EJ, Hill J, Denton OG, Frayling IM, Rødland EA, Vasen H, Mints M, Neffa F, Esperon P, Alvarez K, Kariv R, Rosner G, PineroTA, Gonzalez ML, Kalfayan P, Tjandra D, Winship IM, Macrae F, Möslein G, Mecklin JP, Nielsen M, Møller P. Cancer risks by gene, age, and gender in 6350 carriersof pathogenic mismatch repair variants: findings from the Prospective LynchSyndrome Database. Genet Med. 2020 Jan;22(1):15-25. doi:10.1038/s41436-019-0596-9. Epub 2019 Jul 24. Erratum in: Genet Med. 2020Sep;22(9):1569. Citation on PubMed
  2. Hegde M, Ferber M, Mao R, Samowitz W, Ganguly A; Working Group of the AmericanCollege of Medical Genetics and Genomics (ACMG) Laboratory Quality AssuranceCommittee. ACMG technical standards and guidelines for genetic testing forinherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genet Med. 2014 Jan;16(1):101-16. doi:10.1038/gim.2013.166. Epub 2013 Dec 5. Citation on PubMed
  3. Kohlmann W, Gruber SB. Lynch Syndrome. 2004 Feb 5 [updated 2018 Apr 12]. In:Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A,editors. GeneReviews® [Internet]. Seattle (WA): University of Washington,Seattle; 1993-2020. Available from http://www.ncbi.nlm.nih.gov/books/NBK1211/ Citation on PubMed
  4. Kuiper RP, Vissers LE, Venkatachalam R, Bodmer D, Hoenselaar E, Goossens M,Haufe A, Kamping E, Niessen RC, Hogervorst FB, Gille JJ, Redeker B, Tops CM, van Gijn ME, van den Ouweland AM, Rahner N, Steinke V, Kahl P, Holinski-Feder E,Morak M, Kloor M, Stemmler S, Betz B, Hutter P, Bunyan DJ, Syngal S, Culver JO,Graham T, Chan TL, Nagtegaal ID, van Krieken JH, Schackert HK, Hoogerbrugge N,van Kessel AG, Ligtenberg MJ. Recurrence and variability of germline EPCAMdeletions in Lynch syndrome. Hum Mutat. 2011 Apr;32(4):407-14. doi:10.1002/humu.21446. Epub 2011 Mar 1. Citation on PubMed
  5. Lagerstedt Robinson K, Liu T, Vandrovcova J, Halvarsson B, Clendenning M,Frebourg T, Papadopoulos N, Kinzler KW, Vogelstein B, Peltomäki P, Kolodner RD,Nilbert M, Lindblom A. Lynch syndrome (hereditary nonpolyposis colorectal cancer)diagnostics. J Natl Cancer Inst. 2007 Feb 21;99(4):291-9. Citation on PubMed
  6. Ligtenberg MJ, Kuiper RP, Chan TL, Goossens M, Hebeda KM, Voorendt M, Lee TY, Bodmer D, Hoenselaar E, Hendriks-Cornelissen SJ, Tsui WY, Kong CK, Brunner HG,van Kessel AG, Yuen ST, van Krieken JH, Leung SY, Hoogerbrugge N. Heritablesomatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. Nat Genet. 2009 Jan;41(1):112-7. doi:10.1038/ng.283. Epub 2008 Dec 21. Citation on PubMed
  7. Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003Mar 6;348(10):919-32. Review. Citation on PubMed
  8. Lynch HT, Lynch JF. What the physician needs to know about Lynch syndrome: an update. Oncology (Williston Park). 2005 Apr;19(4):455-63; discussion 463-4, 466, 469. Review. Citation on PubMed
  9. Martín-López JV, Fishel R. The mechanism of mismatch repair and the functionalanalysis of mismatch repair defects in Lynch syndrome. Fam Cancer. 2013Jun;12(2):159-68. doi: 10.1007/s10689-013-9635-x. Review. Citation on PubMed or Free article on PubMed Central
  10. Rahner N, Steinke V, Schlegelberger B, Eisinger F, Hutter P, Olschwang S.Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) - update 2012. Eur J Hum Genet. 2013 Jan;21(1). doi: 10.1038/ejhg.2012.164. Epub2012 Aug 15. Citation on PubMed or Free article on PubMed Central
  11. Tamura K, Kaneda M, Futagawa M, Takeshita M, Kim S, Nakama M, Kawashita N,Tatsumi-Miyajima J. Genetic and genomic basis of the mismatch repair systeminvolved in Lynch syndrome. Int J Clin Oncol. 2019 Sep;24(9):999-1011. doi:10.1007/s10147-019-01494-y. Epub 2019 Jul 4. Review. Erratum in: Int J ClinOncol. 2019 Jul 31;:. Citation on PubMed
  12. Tanakaya K. Current clinical topics of Lynch syndrome. Int J Clin Oncol. 2019 Sep;24(9):1013-1019. doi: 10.1007/s10147-018-1282-7. Epub 2018 May 9. Review. Citation on PubMed
  13. Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Rüschoff J, FishelR, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A,Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S. Revised Bethesda Guidelines for hereditarynonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. JNatl Cancer Inst. 2004 Feb 18;96(4):261-8. Citation on PubMed or Free article on PubMed Central
  14. Weissman SM, Burt R, Church J, Erdman S, Hampel H, Holter S, Jasperson K,Kalady MF, Haidle JL, Lynch HT, Palaniappan S, Wise PE, Senter L. Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group ofthe Americas on Inherited Colorectal Cancer joint practice guideline. J GenetCouns. 2012 Aug;21(4):484-93. doi: 10.1007/s10897-011-9465-7. Epub 2011 Dec 14. Citation on PubMed
  15. Win AK, Jenkins MA, Dowty JG, Antoniou AC, Lee A, Giles GG, Buchanan DD,Clendenning M, Rosty C, Ahnen DJ, Thibodeau SN, Casey G, Gallinger S, Le MarchandL, Haile RW, Potter JD, Zheng Y, Lindor NM, Newcomb PA, Hopper JL, MacInnis RJ.Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer.Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):404-412. doi:10.1158/1055-9965.EPI-16-0693. Epub 2016 Oct 31. Citation on PubMed or Free article on PubMed Central
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
View Times: 1.1K
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 04 Jan 2021
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Academic Video Service
    Feedback