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Tang, P. Clopidogrel Resistance. Encyclopedia. Available online: https://encyclopedia.pub/entry/5937 (accessed on 25 September 2026).
Tang P. Clopidogrel Resistance. Encyclopedia. Available at: https://encyclopedia.pub/entry/5937. Accessed September 25, 2026.
Tang, Peter. "Clopidogrel Resistance" Encyclopedia, https://encyclopedia.pub/entry/5937 (accessed September 25, 2026).
Tang, P. (2020, December 31). Clopidogrel Resistance. In Encyclopedia. https://encyclopedia.pub/entry/5937
Tang, Peter. "Clopidogrel Resistance." Encyclopedia. Web. 31 December, 2020.
Clopidogrel Resistance
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/clopidogrel-resistance

Clopidogrel resistance is a condition in which the drug clopidogrel is less effective than normal in people who are treated with it. Clopidogrel (also known as Plavix) is an antiplatelet drug, which means that it prevents blood cells called platelets from sticking together (aggregating) and forming blood clots. This drug is typically given to prevent blood clot formation in individuals with a history of stroke; heart attack; a blood clot in the deep veins of the arms or legs (deep vein thrombosis); or plaque buildup (atherosclerosis) in the blood vessels leading from the heart, which are opened by placement of a small thin tube (stent).

genetic conditions

References

  1. Hirota T, Eguchi S, Ieiri I. Impact of genetic polymorphisms in CYP2C9 andCYP2C19 on the pharmacokinetics of clinically used drugs. Drug MetabPharmacokinet. 2013;28(1):28-37. Epub 2012 Nov 20. Review. Citation on PubMed
  2. Niu X, Mao L, Huang Y, Baral S, Li JY, Gao Y, Xia YP, He QW, Wang MD, Li M,Zou L, Miao XP, Hu B. CYP2C19 polymorphism and clinical outcomes among patientsof different races treated with clopidogrel: A systematic review andmeta-analysis. J Huazhong Univ Sci Technolog Med Sci. 2015 Apr;35(2):147-156.doi: 10.1007/s11596-015-1404-7. Epub 2015 Apr 16. Review. Citation on PubMed
  3. Scott SA, Sangkuhl K, Stein CM, Hulot JS, Mega JL, Roden DM, Klein TE,Sabatine MS, Johnson JA, Shuldiner AR; Clinical Pharmacogenetics ImplementationConsortium. Clinical Pharmacogenetics Implementation Consortium guidelines forCYP2C19 genotype and clopidogrel therapy: 2013 update. Clin Pharmacol Ther. 2013 Sep;94(3):317-23. doi: 10.1038/clpt.2013.105. Epub 2013 May 22. Citation on PubMed or Free article on PubMed Central
  4. Society for Cardiovascular Angiography and Interventions; Society of Thoracic Surgeons; Writing Committee Members, Holmes DR Jr, Dehmer GJ, Kaul S, Leifer D,O'Gara PT, Stein CM. ACCF/AHA Clopidogrel clinical alert: approaches to the FDA"boxed warning": a report of the American College of Cardiology Foundation TaskForce on Clinical Expert Consensus Documents and the American Heart Association. Circulation. 2010 Aug 3;122(5):537-57. doi: 10.1161/CIR.0b013e3181ee08ed. Epub2010 Jun 28. Citation on PubMed
  5. Uppugunduri CR, Daali Y, Desmeules J, Dayer P, Krajinovic M, Ansari M.Transcriptional regulation of CYP2C19 and its role in altered enzyme activity.Curr Drug Metab. 2012 Oct;13(8):1196-204. Review. Citation on PubMed
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Entry Collection: MedlinePlus
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Update Date: 31 Dec 2020
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