Visual Training in Amblyopia

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1		María Begoña Coco Martín	+ 4182 word(s)	4182	2020-12-17 07:27:00	\|
2	format change	Lily Guo	-68 word(s)	4114	2020-12-30 01:47:59	\| \|
3	format change	Lily Guo	Meta information modification	4114	2021-01-04 09:05:14	\|

This entry is adapted from the peer-reviewed paper 10.3390/jcm9123985

Active vision therapy using perceptual learning and/or dichoptic or binocular environments has shown its potential effectiveness in amblyopia, but some doubts remain about the type of stimuli and the mode and sequence of presentation that should be used.

1. Introduction

Amblyopia is a visual developmental disorder consisting of a reduced best-corrected visual acuity in one or, rarely, both eyes without the presence of any ocular pathology. Etiology is often a high refractive error, anisometropia, strabismus, or a combination of these factors. Less common is deprivation amblyopia, which is caused by a pathology that avoids the eye stimulation during childhood and causes a severe visual deficit^[1]^[2]. The prevalence of amblyopia in childhood is approximately between 1 and 3%, although these values differ among authors^[3]^[4]. In amblyopia, the loss of visual acuity and the presence of many other monocular and binocular visual deficits are the consequence of the anomalies in the visual pathway of the amblyopes, mainly in the striate and extra-striate cortex^[5]. Amblyopic eyes showed worse neural adaptation in V1, V2, V3, V3a, Vp and V4, that is, a reduced cortical automation after a repeated visual task compared with fellow eyes, and a decreased neural response assessed by functional magnetic resonance imaging (fMRI)^[6] as well as a worse effective connectivity between the implied brain regions, which is correlated with the reduced visual acuity^[7].

Over the last few years, vision therapy has been suggested to be an effective option to promote visual rehabilitation and even to accelerate recovery when combined with patching^[8]. New trends in computer-based active vision therapy have been developed for amblyopia treatment, such as the use of perceptual learning environments^[9]^[10]^[11], dichoptic stimulation^[12]^[13]^[14] and binocular training^[15]^[16]. These video games use visual and perceptual tasks, such as orientation discrimination or letter recognition, among others, to cause a response in neuro-modulatory pathways and the enhancement of attentional skills, according to neurophysiological studies^[17]^[18]. These options may support and optimize treatments with spectacles, patching and penalization^[19]^[20].

One of the critical issues when active vision therapy is programmed using perceptual learning and/or a dichoptic or binocular environment is the type of stimuli and the mode and sequence of presentation that should be used. Additionally, depending on the treatment phase, stimuli and environments are specifically selected for promoting visual deficit recovery in a monocular phase, or improving interocular fusion and stereopsis in the binocular phase. Different approaches are commercially available in the form of adaptative software to perform the training at home with online control of the compliance by the practitioner. However, more research is needed on the adequacy of the visual stimuli used for visual training and which psychophysical method would be the most appropriate for the presentation of such stimuli. The aim of the current review article is to gather worthy information on all the main characteristics of the stimulus and the psychophysical method that should be used in amblyopia, depending on the baseline characteristics of the patient, to provide researchers and clinicians a useful guideline for optimizing active vision therapy programs in amblyopia.

2. Related Studies in Stimuli Characteristics and Psychophysical Requirements for Visual Training in Amblyopia

One hundred and forty-three articles were obtained in the first search for documentary support, but only those which met the inclusion criteria were selected. Then, a manual search was performed based on the bibliography of the articles selected. The results were organized in structured sections for a better understanding of the concepts described and an appropriate follow-up of the reader.

2.1. Visual Deficits in Amblyopia

For an appropriate treatment, the stimuli used for visual training should be scientific-based and adapted to the specific characteristics of the amblyopic visual system. Thus, a good comprehension of the neural mechanisms and visual deficits of amblyopia is needed.

2.1.1. Crowding, Flankers and Masking

Crowding is one of the most important visual deficits in amblyopia and is described by Levi as a “deleterious influence of nearby contours of visual discrimination, is a form of inhibitory interaction which is ubiquitous in spatial vision” ^[21]. Crowding is also present in the normal population when the target is surrounded by other stimuli called flankers, with the consequent impairment of the recognition of an object in a clutter^[22]. In the peripheral vision of non-amblyope subjects, a letter becomes unrecognizable when there are other stimuli around it, despite both target and flankers being clearly separated in the retinal point spread function (PSF), this being dependent on target eccentricity^[23]^[24]. In addition, in the foveal vision of the non-amblyope subject, crowding can occur when the target–flankers distance is less than 4–6 min of arc^[22]^[25]^[26]. In amblyopes, crowding occurs with larger distances between targets and flankers, and is related to spatial frequency and target size^[27].

Crowding affects many visual tasks such as letter recognition^[22]^[23]^[24], orientation discrimination^[28]^[29], vernier visual acuity^[30] and stereoacuity tasks^[31]. Furthermore, crowding seems to be the result of a global visual deficit in amblyopia^[21]^[32]^[33], although the values of visual acuity (VA), contrast sensitivity and stereoacuity may not have a large impact on it^[27].

Flankers are the objects located around the target that impair the target perception due to crowding. In strabismic and mixed amblyopia, which present both anisometropia and strabismus, flankers reduce VA^[34]. According to previous authors, when the flankers are complex stimuli, such as letters, the correct term is crowding, but when flankers are sidebars, the term contour interaction should be used^[22].

Finally, masking is the impairment of target perception due to an overlapped element called a mask. For people with amblyopia, obtaining the information of the target from an array of stimuli is harder than it is for normal subjects. Repeated practice of a masking task leads to improvements in target detection time in non-amblyopic subjects^[35], as well as in crowded and uncrowded visual acuity in amblyopes^[26]. Therefore, adding masking tasks to vision therapy might be interesting for future research.

From a neuronal perspective, cortical neuron insufficiency, elevated cortical noise, and abnormal lateral interactions in V1 seem to be related with spatial processing deficits in amblyopic eyes^[33].

2.1.2. Contrast Sensitivity Reduction

Contrast sensitivity is the ability to detect differences in contrast luminance at different spatial frequencies of a grating. Amblyopic eyes can present decreased contrast sensitivity at high spatial frequencies or even at all the spatial frequencies, which is the consequence of alterations in the lateral geniculate nucleus and visual striate cortex^[36]. Specifically, there are some differences according to its etiology. In anisometropic amblyopia, a significant decrease in global contrast sensitivity compared with normal subjects is commonly reported, while strabismic amblyopes can show normal or increased low frequency contrast sensitivity^[37]. It is interesting that a loss in contrast sensitivity could persist despite the recovery of the visual acuity after amblyopia treatment. However, several authors reported improvements in contrast sensitivity after vision training with perceptual learning in amblyopic subjects ^[11]^[38]^[39]. Thus, amblyopia management should involve contrast sensitivity tasks for a global approach^[38], with the aim of obtaining similar values in both eyes and facilitating binocular vision.

2.1.3. Stereopsis Impairment

Stereopsis or stereoacuity is the perception of three-dimensionality because of the cortical combination between the images from each eye. For obtaining correct stereoscopic perception, both eyes should have an adequate and similar visual acuity and contrast sensitivity in the presence of ocular alignment ^[40]. Therefore, stereopsis is one of the main features that should be assessed in the clinical management of amblyopia, since it usually is decreased or absent due to the differences in the perceived images between the amblyopic and the fellow eye. In anisometropic amblyopia, stereopsis is reduced, although it depends on the degree of anisometropia and the loss of visual acuity in the amblyopic eye. In strabismic or mixed amblyopia with constant deviation greater than 12 prism diopters, subjects are stereoblind due to the lack of bifoveal fixation^[41]. Stereopsis is important for appropriate performance in activities such as driving, sports or hand-to-eye coordination tasks, although further research is needed to understand more about how different values of stereopsis interfere with daily activities^[16]. In accordance with the aim of this review, it is relevant to note that during the treatment of amblyopia, stereopsis should be assessed and trained, since some authors suggested that vision therapy can also improve stereoacuity^[16]^[42]^[43]^[44]. Thus, designing exercises with specific stimuli for stereopsis training assumes great significance as part of the treatment in amblyopic subjects.

Recent evidence from functional magnetic resonance imaging (fMRI) studies on the cortical processing of vision in amblyopia shows that, during amblyopic eye stimulation, not only do primary and secondary visual areas present reduced activation when compared to fellow-fixing eye stimulation, but so too do higher-level visual areas, such as the parieto-occipital and temporal cortex. These findings could explain binocular vision deficits in amblyopic patients [45].

2.2. Visual Stimuli Used for Vision Training in Amblyopia

There are many types of stimuli which are used in vision training for amblyopia. For example, video games or films are usually used in published studies, commonly in dichoptic training. Despite the fact that they seem to be effective, they also have some features which could be a limitation. Some of these treatments are based on dichoptic training or monocular stimulation, and use eye–hand coordination games [12,14,46] and popular films [47] which are not specifically designed for treating amblyopia, or do not adjust the difficulty of the training to the patient’s progress. However, there are four types of stimuli which have shown to be effective in clinical research that can be easily added to the amblyopia training software, with the possibility of modification according to the patient’s evolution, and these are letter optotypes [48,49], Gabor’s patches [9,48,49,50,51,52], Vernier’s stimuli [53] and random-dot stereograms [16,54] (Table 1).

Table 1. Summary of the main outcomes obtained and the type of stimuli used in different clinical studies that have been revised in the current review.

Authors	Design	N	Type of Amblyopia	Enviroment	Stimulus	Population	Main Outcome
Jia et al., 2018	NRSI	19	Aniso	Perceptual learning	Gabor’s patch	Young adult	AUCSF improved from 8.41 ± 1.09 to 15.48 ± 1.61 VA increased about 2 lines
Liu et al., 2018	NRSI	13	9 aniso, 1 strab, 3 mixed	DT	Gabor’s patch	Young adults	Stereopsis improved 26.5% ± 6.9%
Avram et al., 2013	Case series	5	Aniso	PL	Letter optotypes	Children	Significant improvement of VA and CS after training
Chen et al., 2016	NRSI	13	Aniso	PL	Gabor’s patch	Teenagers and young adults	VA increased 1.64 ± 0.06 lines CSF improved significantly
Gambacorta et al., 2018	NRSI	29	Aniso	PL and DT	Gabor’s patch	Teenagers	VA improved 0.1 ± 0.03 LogMAR after 10 h of training
Zhang et al., 2013	Retrospective	341	Aniso, strab, ametropic and mixed	PL	Gabor’s patch Letter optotype	Children	Improvement in VA with PL was similar to with patching
Levi et al., 1997	NRSI	11	4 aniso, 4 strab, 3 mixed	PL	Vernier’s stimulus	Adults	Improvement in Vernier acuity
Portela-Camino et al., 2018	RCT	32	2 aniso, 18 strab, 10 mixed, 2 isoametropic	PL	RDS	Children	Stereopsis increased about 50% with RPST and 46.42% with Wirt circles
Martín-González et al., 2020	NRSI	16	2 aniso, 8 strab, 4 mix, 2 isoametropic	PL	RDS	Children	Stereopsis experienced a significant improvement

2.2.1. Letter Optotypes

As aforementioned, letter recognition is affected by crowding and interaction contours in amblyopia [55], but its use in visual training using perceptual learning approaches can be useful, since many of the parameters of these optotypes can be modified, such as size, contrast sensitivity, presence or absence of flankers, orientation, or motion (Figure 1). For this reason, visual training based on letter optotypes has been used in several scientific articles [56,57].

Figure 1. Letter optotype: Snellen E.

2.2.2. Gabor’s Patches

These are sinusoidal gratings with a Gaussian envelope, which also are commonly used in amblyopia studies, since experimental research demonstrated that gratings with a neutral background can cause selective cortical responses for orientation and contrast, which additionally correlates with fMRI findings (Figure 2) [58,59]. Amblyopia affects high spatial frequency, contrast sensitivity and orientation discrimination, among others visual deficits. Therefore, Gabor´s patches also can be used in perceptual learning, since they allow clinicians to apply many visual tasks, adapting contrast, spatial frequency, size, and other parameters according to each individual case [9,48,49,50,51,52,60].

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Figure 2. Gabor’s patch.

2.2.3. Random-Dot Stereograms

This stimulus consists of an array of dots randomly presented to the subjects for specific stereoscopic perception stimulation (Figure 3). Usually, random-dot stimuli are used for stereoacuity assessment in clinical practice, but recent published works showed their application also in improving stereopsis values in amblyopia [16,54]. The use of a random-dot stereogram entails a cortical activation in the early visual cortex, particularly with mixed-polarity stimulus [61], and a small but significant activation of the pupil and accommodation responses [62]. Additionally, the optimal size of the dots should be considered for well-designed random-dot stimuli, since the literature suggests that larger dots implicate better stereo-perception [63].

Figure 3. Example of a random-dot stimulus. The dark “E” represents the section of the image that is perceived in depth when seen by subjects with an appropriate binocular vision.

2.2.4. Vernier’s Stimulus

Vernier’s stimuli are based on the perception of the continuity of a lineal stimulus, and are related with the concept of visual hyperacuity, which also is decreased in amblyopia [64]. The less separate the lineal stimuli are, the more difficult it is to perceive discontinuity for amblyopic subjects (Figure 4).

Figure 4. Vernier’s stimulus.

3.3. Parameters That Can Be Modified in the Visual Stimuli

There are many parameters that should be considered when performing visual training to treat amblyopia. For such purpose, the characteristics of stimuli that are described below should be considered due to their relationship with the neural mechanism of amblyopic subjects.

3.3.1. Spatial–Temporal Frequency

All types of amblyopes show worse contrast sensitivity for high spatial frequencies [1], which can be related with a worse response to orientation tasks with the increase in spatial frequency. In 1977, Levi and Harwerth [65] reported that the reduction in contrast sensitivity in anisometropic and strabismic amblyopes was due to neural mechanisms, since optical factors and eccentric fixation were dismissed. This deficit was significant for both long and short stimulus durations. In anisometropic amblyopia, a slight decrease could also be observed in the low and middle frequencies, although this can be partially attributed to optical factors according to some authors [66]. These findings are also reported in myopic anisometropic amblyopia [67]. Furthermore, in the case of meridional amblyopia, the visual deficit is dependent on the cylinder axis [68,69]. In strabismic amblyopia, the loss in contrast sensitivity is more significant and can affect mainly high frequencies or even all spatial frequencies [70].

Amblyopes also show temporal frequency deficits. Yang et al. [71] reported a larger temporal discrimination threshold in amblyopic eyes in 5 and 10 Hz stimuli compared with the fellow eyes of the same subject in anisometropic and strabismic amblyopia, and between fellow eyes and normal eyes only in strabismic amblyopes. This temporal frequency deficit did not show a correlation with logarithmic minimum angle of resolution (logMAR) visual acuity, although it was influenced by attention. A greater attention distribution caused larger differences between normal and amblyopic eyes. Furthermore, temporal deficits also seemed to affect binocular conditions, since a slightly larger interocular imbalance was recently reported in mid-to-low temporal frequencies by Kosovicheva et al. [72], although stereopsis was unaffected. These findings are supported by other authors, such as Bonneh et al. [73], who reported a higher time latency when a stimulus is shown to an amblyopic eye compared to a non-amblyopic eye, as well as by the worse response to flickering stimulus compared to steady stimulus in amblyopes that was described by Ruddock et al. [74].

Thus, spatial and temporal frequency should be adapted to the individual features of amblyopic eyes, using low spatial frequencies and steady stimuli at the beginning of visual therapy in amblyopia, as the evidence suggests, because this is easier to perceive for amblyopic patients. As the patient improves, higher frequencies and flickering stimulus can be used. Likewise, flickering stimulus can be used to maintain patient attention [71].

3.3.2. Contrast Sensitivity and Luminance

Monocular contrast sensitivity loss in amblyopia has been widely reported by many authors—even in treated amblyopes who achieved 20/20 visual acuity in clinical and experimental studies [50,75,76,77,78]. In addition, contrast reduction increases blur and crowding perception in monocular conditions [79]. Furthermore, a functional magnetic resonance imaging (fMRI) study showed a deficit in the contrast sensitivity in the V1 and extra-striate cortex, mainly in high contrast, due to a neural deficit where the loss of function is greater for parvocellular pathway activity [80]. Therefore, there is an evident and well-documented monocular deficit in contrast sensitivity in amblyopia. The affectation of this deficit to binocular vision in amblyopia should also be considered. The binocular summation of contrast sensitivity in amblyopia is an important factor to consider during amblyopia treatment. Pardhan et al. [81] reported that in all amblyopes, binocular summation decreases until inhibition is produced, as the average interocular differences in contrast sensitivity increase. Binocular inhibition was observed especially in middle to high frequencies, and seemed to be higher in strabismic amblyopia. This could be the reason for the report of better vision with the non-amblyopic eye by some amblyopes compared to the use of both eyes together. However, the presence of sensory fusion and stereopsis should also be considered so as to understand this effect in daily practice. According to this, optimal refractive correction and amblyopia treatment is supposed to reduce interocular differences in contrast sensitivity and, therefore, improve binocular summation.

Regarding the perception of deficits in luminance, it has been reportedly observed in dichoptic conditions, which suggests that interocular suppression has an impact on luminance processing [79]. Therefore, treatment with high contrast stimuli may be the best option during monocular training at the beginning of the vision therapy, since it is related with a more affected pathway and is easier to perceive for the eye. Furthermore, to fit the luminance during dichoptic therapy so as to decrease crowding and interocular suppression seems to also be an appropriate option. Orientation and contrast detection tasks can be used for training contrast sensitivity loss in amblyopia, since they were shown to improve letter recognition and contrast sensitivity [82].

3.3.3. First- and Second-Order Stimulus

First-order stimuli are luminance-defined, mainly processed in the striate cortex (V1), and are related to orientation and spatial frequency perception. However, second-order stimuli are contrast-defined, but are also related with movement and orientation. Second-order stimuli are processed in V2, V3 and V5, that is, the extra-striate cortex [83]. Some authors have shown higher crowding in the second-order stimulus than the first-order when the target and flankers are of the same order [84]. Psychophysical experiments have also shown that training with first-order stimulus improves performance in detection tasks with luminance-defined letters, and the improvement is transferred to a second-order detection task with contrast-defined letters, but this does not occur in reverse [85].

2.3.4. Color and Achromatic Stimuli

Amblyopes have shown deficits in processing color vision measured by neuroimaging, blood oxygen level-dependent (BOLD) activation and psychophysical tests. Bradley et al. [86] reported that in amblyopes, a loss of chromatic contrast sensitivity coincides with luminance contrast sensitivity. This means that contrast sensitivity decreased as spatial frequency increased in psychophysical experiments, while there was no difference in color discrimination in conventional clinical testing when low spatial frequencies were used [86]. These results have been supported by the most recent developments. Hess et al. [87] described a reduced cortical response to chromatic stimuli in the lateral geniculate nucleus (LGN), V1, V2, V3, VP, V3a and V4 in amblyopes measured with fMRI and BOLD signal. The dominant eye of amblyopes has shown a statistically better response for chromatic stimuli than achromatic, especially for the red/green (R/G) signal, while the amblyopic eye has shown an overall decreased chromatic response [87]. It is interesting to highlight the selective loss response in the L/M opponent cone signal measured in LGN, while in the striate and extra-striate cortex the lower response was reported in both the L/M opponent cone and the S cone response. These findings, based on experimental research, lead us to suggest the use of achromatic stimuli for the initial stages of vision therapy in order to induce larger neural responses, since color and luminance processing are physiologically separated. Color stimuli might be added in advanced stages of treatment for completing the therapy, although there is no empirical evidence about how chromatic stimuli can affect vision recovery, and this should be investigated in depth in the future. It is important to remark that these deficits in color processing cannot be confused with impairments in color perception, such as daltonism, since color perception is normal in amblyopic subjects.

2.3.5. Figure–Ground Segregation

Visual deficits and crowding in amblyopes do not inhibit their ability to segregate an “E” from a mask made of spatial frequencies [88]. However, there is a deficit in figure–ground segregation when a light spot is used as a target and a random-dot noise as a mask [89]. Figure–ground segregation tasks also showed a decrease in temporal frequency resolution in amblyopic eyes when compared with the fellow eye, according to the results of Spang and Fahle [90]. An interesting aspect of the results of these authors is that spatial frequency does not seem to be the cause for this decrease, since similar temporal thresholds were reported when the spatial resolution was deteriorated in dominant eyes using plus lenses, although a small correlation between visual acuity and a longer temporal delay in amblyopic eyes was found. These results are like those reported by Wang et al. [91], who observed a worse performance in motion-defined and texture-defined tasks in amblyopes, although there were no significant differences in the global motion task. Therefore, amblyopia is a spatial and temporal disturbance that shows some deficits in figure–ground segregation, which should be considered during vision training due to its relationship with the presence or not of masking stimuli. Nonetheless, further research is needed in order to determine the underlying neural mechanisms and how they affect amblyopic subjects, in order to optimize the visual training concerning these issues.

Until now, some authors have proposed interesting neural network architectures to explain the theoretical basis of this process, but without systematic evaluation against human perception in terms of figure–ground rules and their combinations. fMRI studies have shown that illusory contours elicit responses in the Lateral Occipital Complex and that salient regions of the figure activate this area, but it still remains unknown which cues are used by the brain to detect them and how these image cues are computed. In 2008, Domijan and Šetić [92] proposed a neural model based on the interaction between the ventral and the dorsal processing stream, which can account for classical and recent principles of figure–ground organization. However, their results contradict the physiological findings about border ownership responses in V2, so further research in this field is still required [93].

3.3.6. Signal–Noise

In the presence of noise, the stimuli detection efficiency decreases with the increase in spatial frequency, and therefore internal noise seems to be stimulus-dependent. Furthermore, amblyopes show an internal noise which is partially dependent on external noise. Therefore, there is a decreased efficiency in stimuli perception when external noise and/or spatial frequency increase [94,95,96,97]. Some authors suggest there are compensating mechanisms which are focused on low spatial frequencies in amblyopic eyes [98]. Motion and orientation integration are affected by the signal–noise ratio in amblyopia, although this fact is not justified by the low visibility of amblyopic eyes due to the deficits of V1. Therefore, it is suggested that the extra-striate cortex plays an important role in these alterations, since there are areas, such as V5, that are affected by amblyopia [99]. Based on these findings, visual training in amblyopia may start with minimum noise level stimuli in order to facilitate the amblyopic eye perception, and then higher levels of noise can be used as the amblyopia eye improves.

2.3.7. Steady and Dynamic Stimulus

Motion perception is rarely assessed clinically, but there are motion perception and oculomotor deficits reported in amblyopia [32] that should be considered for a better understanding of this ocular disorder and its management. Anisometropic amblyopia has shown the same pattern of cortical activation with motion displacement stimuli in fMRI, but this pattern has shown a lesser extent of activation than controls, and this fact was even worse in strabismic amblyopia [100]. It should be considered that global motion sensitivity depends on the spatial and temporal parameters of the motion stimulus. Amblyopic children have shown deficits in finer spatial displacements, regardless of temporal parameters, which typically mature later during development [101,102]. Furthermore, speed motion perception is not affected by the reduction in perceived luminance of the amblyopic eye in dichoptic conditions [103], but there are some motion-defined form deficits in amblyopia that affect both amblyopic and fellow eyes, possibly due to the altered binocular mechanisms [104]. In terms of treatment, there is little information about how spectacles, occlusion or vision therapy affect motion perception. Giaschi et al. [105] did not find an improvement in motion perception after occlusion therapy, while Chen et al. [106] reported that baseline differences in motion responses between amblyopes and controls are solved after treatment. Birch et al. [104] reported some benefits in motion perception after binocular therapy. Based on these facts, steady or long and slow-motion stimuli may be a good option for starting visual training in amblyopia.

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María Begoña Coco Martín

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