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Guo, L. PML Gene. Encyclopedia. Available online: (accessed on 03 March 2024).
Guo L. PML Gene. Encyclopedia. Available at: Accessed March 03, 2024.
Guo, Lily. "PML Gene" Encyclopedia, (accessed March 03, 2024).
Guo, L. (2020, December 25). PML Gene. In Encyclopedia.
Guo, Lily. "PML Gene." Encyclopedia. Web. 25 December, 2020.
PML Gene

promyelocytic leukemia


1. Introduction

The PML gene provides instructions for a protein that acts as a tumor suppressor, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. The PML protein is found in distinct structures in the nucleus of a cell called PML nuclear bodies (PML-NBs). In the PML-NBs, the PML protein interacts with other proteins that are involved in cell growth and division (proliferation) and self-destruction (apoptosis). The PML protein is able to block cell proliferation and induce apoptosis in combination with other proteins. Researchers believe that the structure of the PML-NBs is required for blocking proliferation and inducing apoptosis.

2. Health Conditions Related to Genetic Changes

2.1. Acute promyelocytic leukemia

Gene mutations can be acquired during a person's lifetime and are present only in certain cells. These mutations are called somatic mutations, and they are not inherited. A somatic mutation involving the PML gene causes acute promyelocytic leukemia, a cancer of the blood forming tissue (bone marrow). Acute promyelocytic leukemia is characterized by an accumulation of immature white blood cells, called promyelocytes, in the bone marrow. A rearrangement (translocation) of genetic material between chromosomes 15 and 17, written as t(15;17), fuses part of the PML gene on chromosome 15 with part of another gene on chromosome 17 called RARA. The protein produced from this fused gene, PML-RARα, functions differently than the protein products of the normal PML and RARA genes.

The PML-RARα protein does not localize to the PML-NBs, and the structures do not form properly. The PML-RARα protein is unable to block cell proliferation or induce apoptosis.

Additionally, the function of the RARα protein, the product of the RARA gene, is disrupted. Normally, this protein is involved in the regulation of gene transcription, which is the first step in protein production. Specifically, this protein helps control the transcription of certain genes important in the maturation (differentiation) of white blood cells beyond the promyelocyte stage. However, the PML-RARα protein blocks (represses) gene transcription.

The PML-RARα protein allows abnormal cell proliferation and blocks the differentiation of white blood cells at the promyelocyte stage. As a result, excess promyelocytes accumulate in the bone marrow and normal white blood cells cannot form, leading to acute promyelocytic leukemia.

3. Other Names for This Gene

  • MYL
  • promyelocytic leukemia protein
  • promyelocytic leukemia, inducer of
  • RING finger protein 71
  • RNF71
  • TRIM19
  • tripartite motif protein TRIM19


  1. Collins SJ. The role of retinoids and retinoic acid receptors in normalhematopoiesis. Leukemia. 2002 Oct;16(10):1896-905. Review.
  2. de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. The PML-RARalpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell. 1991 Aug 23;66(4):675-84.
  3. Pandolfi PP. Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Hum Mol Genet. 2001 Apr;10(7):769-75. Review.
  4. Salomoni P, Pandolfi PP. The role of PML in tumor suppression. Cell. 2002 Jan 25;108(2):165-70. Review.
  5. Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. Translocations of theRARalpha gene in acute promyelocytic leukemia. Oncogene. 2001 Oct29;20(49):7186-203. Review.
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Update Date: 25 Dec 2020