Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1
Vivi Li
 + 399 word(s) 399 2020-12-15 07:53:42

Video Upload Options

Do you have a full video?
Send video materials Upload full video

Confirm

Are you sure to Delete?
Yes No
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Li, V. FOXN1 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5581 (accessed on 28 April 2024).
Li V. FOXN1 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5581. Accessed April 28, 2024.
Li, Vivi. "FOXN1 Gene" Encyclopedia, https://encyclopedia.pub/entry/5581 (accessed April 28, 2024).
Li, V. (2020, December 25). FOXN1 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5581
Li, Vivi. "FOXN1 Gene." Encyclopedia. Web. 25 December, 2020.
FOXN1 Gene
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/foxn1

Forkhead box N1

genes

1. Normal Function

The FOXN1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. On the basis of this action, the FOXN1 protein is called a transcription factor.

The FOXN1 protein is important for development of the skin, hair, nails, and immune system. Studies suggest that this protein helps guide the formation of hair follicles and the growth of fingernails and toenails. The FOXN1 protein also plays a critical role in the formation of the thymus, which is a gland located behind the breastbone where immune system cells called T cells mature and become functional. T cells recognize and attack foreign invaders, such as viruses and bacteria, to help prevent infection.

Researchers suspect that the FOXN1 protein is also involved in the development of the brain and spinal cord (central nervous system), although its role is unclear.

2. Health Conditions Related to Genetic Changes

2.1 T-cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy

At least one mutation in the FOXN1 gene has been found to cause T-cell immunodeficiency, congenital alopecia, and nail dystrophy, a condition that affects the immune system and growth of the hair and nails. The known mutation, which is written as Arg255Ter or R255X, replaces the protein building block (amino acid) arginine with a signal to stop protein production. No functional FOXN1 protein is produced from the mutated gene.

A lack of FOXN1 protein prevents the formation of the thymus. When this gland is not present, the immune system cannot produce mature, functional T cells to fight infections. As a result, people with T-cell immunodeficiency, congenital alopecia, and nail dystrophy develop recurrent serious infections starting early in life. Loss of the FOXN1 protein also prevents the formation of hair follicles, leading to an absence of hair (alopecia). In addition, a shortage of this protein causes malformations of the fingernails and toenails (nail dystrophy).

Researchers have described abnormalities of the central nervous system in at least two cases of T-cell immunodeficiency, congenital alopecia, and nail dystrophy. However, it is not yet known whether central nervous system abnormalities are a common feature of this condition. It is unclear how a shortage of the FOXN1 protein might contribute to these abnormalities.

3. Other Names for This Gene

  • FKHL20

  • forkhead box protein N1

  • RONU

  • Rowett nude

  • WHN

  • winged helix nude

  • winged-helix nude

  • winged-helix transcription factor nude

References

  1. Adriani M, Martinez-Mir A, Fusco F, Busiello R, Frank J, Telese S, MatrecanoE, Ursini MV, Christiano AM, Pignata C. Ancestral founder mutation of the nude(FOXN1) gene in congenital severe combined immunodeficiency associated withalopecia in southern Italy population. Ann Hum Genet. 2004 May;68(Pt 3):265-8.
  2. Amorosi S, D'Armiento M, Calcagno G, Russo I, Adriani M, Christiano AM, WeinerL, Brissette JL, Pignata C. FOXN1 homozygous mutation associated with anencephalyand severe neural tube defect in human athymic Nude/SCID fetus. Clin Genet. 2008 Apr;73(4):380-4. doi: 10.1111/j.1399-0004.2008.00977.x.
  3. Amorosi S, Vigliano I, Del Giudice E, Panico L, Maruotti GM, Fusco A,Quarantelli M, Ciccone C, Ursini MV, Martinelli P, Pignata C. Brain alteration ina Nude/SCID fetus carrying FOXN1 homozygous mutation. J Neurol Sci. 2010 Nov15;298(1-2):121-3. doi: 10.1016/j.jns.2010.08.066.
  4. Pignata C, Fusco A, Amorosi S. Human clinical phenotype associated with FOXN1 mutations. Adv Exp Med Biol. 2009;665:195-206. Review.
  5. Pignata C. A lesson for unraveling complex aspects of novel immunodeficienciesfrom the human equivalent of the nude/SCID phenotype. J Hematother Stem Cell Res.2002 Apr;11(2):409-14. Review.
  6. Vigliano I, Gorrese M, Fusco A, Vitiello L, Amorosi S, Panico L, Ursini MV,Calcagno G, Racioppi L, Del Vecchio L, Pignata C. FOXN1 mutation abrogatesprenatal T-cell development in humans. J Med Genet. 2011 Jun;48(6):413-6. doi:10.1136/jmg.2011.089532.
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Vivi Li
View Times: 283
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 25 Dec 2020
Table of Contents
    1000/1000
    Hot Most Recent
    Feedback