Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Vivi Li + 774 word(s) 774 2020-12-15 07:53:41

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Li, V. FOXL2 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5578 (accessed on 21 September 2026).
Li V. FOXL2 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5578. Accessed September 21, 2026.
Li, Vivi. "FOXL2 Gene" Encyclopedia, https://encyclopedia.pub/entry/5578 (accessed September 21, 2026).
Li, V. (2020, December 25). FOXL2 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5578
Li, Vivi. "FOXL2 Gene." Encyclopedia. Web. 25 December, 2020.
FOXL2 Gene
Edit

Forkhead box L2

genes

References

  1. Beysen D, De Jaegere S, Amor D, Bouchard P, Christin-Maitre S, Fellous M,Touraine P, Grix AW, Hennekam R, Meire F, Oyen N, Wilson LC, Barel D,Clayton-Smith J, de Ravel T, Decock C, Delbeke P, Ensenauer R, Ebinger F,Gillessen-Kaesbach G, Hendriks Y, Kimonis V, Laframboise R, Laissue P, Leppig K, Leroy BP, Miller DT, Mowat D, Neumann L, Plomp A, Van Regemorter N, Wieczorek D, Veitia RA, De Paepe A, De Baere E. Identification of 34 novel and 56 known FOXL2 mutations in patients with Blepharophimosis syndrome. Hum Mutat. 2008Nov;29(11):E205-19. doi: 10.1002/humu.20819.
  2. Beysen D, De Paepe A, De Baere E. FOXL2 mutations and genomic rearrangementsin BPES. Hum Mutat. 2009 Feb;30(2):158-69. doi: 10.1002/humu.20807. Review.
  3. Beysen D, Raes J, Leroy BP, Lucassen A, Yates JR, Clayton-Smith J, Ilyina H,Brooks SS, Christin-Maitre S, Fellous M, Fryns JP, Kim JR, Lapunzina P, Lemyre E,Meire F, Messiaen LM, Oley C, Splitt M, Thomson J, Van de Peer Y, Veitia RA, DePaepe A, De Baere E. Deletions involving long-range conserved nongenic sequences upstream and downstream of FOXL2 as a novel disease-causing mechanism inblepharophimosis syndrome. Am J Hum Genet. 2005 Aug;77(2):205-18.
  4. Caburet S, Georges A, L'Hôte D, Todeschini AL, Benayoun BA, Veitia RA. Thetranscription factor FOXL2: at the crossroads of ovarian physiology andpathology. Mol Cell Endocrinol. 2012 Jun 5;356(1-2):55-64. doi:10.1016/j.mce.2011.06.019.
  5. Dipietromaria A, Benayoun BA, Todeschini AL, Rivals I, Bazin C, Veitia RA.Towards a functional classification of pathogenic FOXL2 mutations usingtransactivation reporter systems. Hum Mol Genet. 2009 Sep 1;18(17):3324-33. doi: 10.1093/hmg/ddp273.
  6. Kuo FT, Bentsi-Barnes IK, Barlow GM, Pisarska MD. Mutant Forkhead L2 (FOXL2)proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa celldifferentiation. Endocrinology. 2011 Oct;152(10):3917-29. doi:10.1210/en.2010-0989.
  7. Laissue P, Lakhal B, Benayoun BA, Dipietromaria A, Braham R, Elghezal H,Philibert P, Saâd A, Sultan C, Fellous M, Veitia RA. Functional evidenceimplicating FOXL2 in non-syndromic premature ovarian failure and in theregulation of the transcription factor OSR2. J Med Genet. 2009 Jul;46(7):455-7.doi: 10.1136/jmg.2008.065086.
  8. Moumné L, Batista F, Benayoun BA, Nallathambi J, Fellous M, Sundaresan P,Veitia RA. The mutations and potential targets of the forkhead transcriptionfactor FOXL2. Mol Cell Endocrinol. 2008 Jan 30;282(1-2):2-11.Review.
  9. Shah SP, Köbel M, Senz J, Morin RD, Clarke BA, Wiegand KC, Leung G, Zayed A,Mehl E, Kalloger SE, Sun M, Giuliany R, Yorida E, Jones S, Varhol R, SwenertonKD, Miller D, Clement PB, Crane C, Madore J, Provencher D, Leung P, DeFazio A,Khattra J, Turashvili G, Zhao Y, Zeng T, Glover JN, Vanderhyden B, Zhao C,Parkinson CA, Jimenez-Linan M, Bowtell DD, Mes-Masson AM, Brenton JD, AparicioSA, Boyd N, Hirst M, Gilks CB, Marra M, Huntsman DG. Mutation of FOXL2 ingranulosa-cell tumors of the ovary. N Engl J Med. 2009 Jun 25;360(26):2719-29.doi: 10.1056/NEJMoa0902542.
  10. Todeschini AL, Dipietromaria A, L'hôte D, Boucham FZ, Georges AB,Pandaranayaka PJ, Krishnaswamy S, Rivals I, Bazin C, Veitia RA. Mutationalprobing of the forkhead domain of the transcription factor FOXL2 providesinsights into the pathogenicity of naturally occurring mutations. Hum Mol Genet. 2011 Sep 1;20(17):3376-85. doi: 10.1093/hmg/ddr244.
More
Upload a video for this entry
Information
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Vivi Li
View Times: 774
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 25 Dec 2020
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service