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Li, V. FGFR2 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5524 (accessed on 21 September 2026).
Li V. FGFR2 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5524. Accessed September 21, 2026.
Li, Vivi. "FGFR2 Gene" Encyclopedia, https://encyclopedia.pub/entry/5524 (accessed September 21, 2026).
Li, V. (2020, December 25). FGFR2 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5524
Li, Vivi. "FGFR2 Gene." Encyclopedia. Web. 25 December, 2020.
FGFR2 Gene
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/fgfr2

Fibroblast growth factor receptor 2: The FGFR2 gene provides instructions for making a protein called fibroblast growth factor receptor 2 (FGFR2). 

genes

References

  1. Azoury SC, Reddy S, Shukla V, Deng CX. Fibroblast Growth Factor Receptor 2(FGFR2) Mutation Related Syndromic Craniosynostosis. Int J Biol Sci. 2017 Nov2;13(12):1479-1488. doi: 10.7150/ijbs.22373.
  2. Carinci F, Pezzetti F, Locci P, Becchetti E, Carls F, Avantaggiato A,Becchetti A, Carinci P, Baroni T, Bodo M. Apert and Crouzon syndromes: clinicalfindings, genes and extracellular matrix. J Craniofac Surg. 2005 May;16(3):361-8.Review.
  3. Chokdeemboon C, Mahatumarat C, Rojvachiranonda N, Tongkobpetch S,Suphapeetiporn K, Shotelersuk V. FGFR1 and FGFR2 mutations in Pfeiffer syndrome. J Craniofac Surg. 2013 Jan;24(1):150-2. doi: 10.1097/SCS.0b013e3182646454.
  4. Ibrahimi OA, Chiu ES, McCarthy JG, Mohammadi M. Understanding the molecularbasis of Apert syndrome. Plast Reconstr Surg. 2005 Jan;115(1):264-70. Review.
  5. Katoh M. Therapeutics Targeting FGF Signaling Network in Human Diseases.Trends Pharmacol Sci. 2016 Dec;37(12):1081-1096. doi: 10.1016/j.tips.2016.10.003.
  6. Lajeunie E, Heuertz S, El Ghouzzi V, Martinovic J, Renier D, Le Merrer M,Bonaventure J. Mutation screening in patients with syndromic craniosynostosesindicates that a limited number of recurrent FGFR2 mutations accounts for severe forms of Pfeiffer syndrome. Eur J Hum Genet. 2006 Mar;14(3):289-98.
  7. Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J. Structural basis forreduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition andactivation. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19802-7.
  8. McGlaughlin KL, Witherow H, Dunaway DJ, David DJ, Anderson PJ. Spectrum ofAntley-Bixler syndrome. J Craniofac Surg. 2010 Sep;21(5):1560-4. doi:10.1097/SCS.0b013e3181ec6afe.
  9. Naimi B, Latil A, Fournier G, Mangin P, Cussenot O, Berthon P. Down-regulationof (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) isassociated with malignant progression in human prostate. Prostate. 2002 Aug1;52(3):245-52.
  10. Rohmann E, Brunner HG, Kayserili H, Uyguner O, Nürnberg G, Lew ED, Dobbie A,Eswarakumar VP, Uzumcu A, Ulubil-Emeroglu M, Leroy JG, Li Y, Becker C, LehnerdtK, Cremers CW, Yüksel-Apak M, Nürnberg P, Kubisch C, Schlessinger J, van BokhovenH, Wollnik B. Mutations in different components of FGF signaling in LADDsyndrome. Nat Genet. 2006 Apr;38(4):414-7.Genet. 2006 Apr;38(4):495. Kubisch, Chriütian [corrected to Kubisch, Christian].
  11. Shams I, Rohmann E, Eswarakumar VP, Lew ED, Yuzawa S, Wollnik B, Schlessinger J, Lax I. Lacrimo-auriculo-dento-digital syndrome is caused by reduced activityof the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. Mol Cell Biol. 2007 Oct;27(19):6903-12.
  12. Shin EY, Lee BH, Yang JH, Shin KS, Lee GK, Yun HY, Song YJ, Park SC, Kim EG.Up-regulation and co-expression of fibroblast growth factor receptors in humangastric cancer. J Cancer Res Clin Oncol. 2000 Sep;126(9):519-28.
  13. Wilkie AO, Patey SJ, Kan SH, van den Ouweland AM, Hamel BC. FGFs, theirreceptors, and human limb malformations: clinical and molecular correlations. Am J Med Genet. 2002 Oct 15;112(3):266-78. Review.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Vivi Li
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Entry Collection: MedlinePlus
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Update Date: 25 Dec 2020
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