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Pneumonia is a common and severe illness that requires prompt and effective management. Advanced, rapid, and accurate tools are needed to diagnose patients with severe bacterial pneumonia, and to rapidly select appropriate antimicrobial therapy, which must be initiated within the first few hours of care. Two multiplex molecular tests, Unyvero HPN and FilmArray Pneumonia+ Panel, have been developed using the multiplex polymerase chain reaction (mPCR) technique to rapidly identify pathogens and their main antibiotic resistance mechanisms from patient respiratory specimens. Performance evaluation of these tests showed strong correlations with reference techniques.
Unyvero HPN | FilmArray Pneumonia+ Panel | |
---|---|---|
Number of targets | 36 | 33 |
Turnaround time | 5 h | 90 min |
Type of detection | Semiquantitative (+ to +++) | Quantitative (104 to ≥107) |
Included pathogens | ||
Bacteria | ||
Gram-positive cocci | ||
Staphylococcus aureus | x | x |
Streptococcus agalactiae | x | |
Streptococcus pneumoniae | x | x |
Streptococcus pyogenes | x | |
Gram-negative cocci | ||
Moraxella catarrhalis | x | x |
Gram-negative bacilli | ||
Haemophilus influenzae | x | x |
Group 1 Enterobacterales | ||
Escherichia coli | x | x |
Proteus spp. | x | x |
Group 2 Enterobacterales | ||
Klebsiella oxytoca | x | x |
Klebsiella pneumoniae | x | x |
Klebsiella variicola | x | |
Group 3 Enterobacterales | ||
Enterobacter cloacae complex | x | x |
Citrobacter freundii | x | |
Enterobacter cloacae complex | x | x |
Klebsiella aerogenes (Enterobacter aerogenes) | x | x |
Morganella morganii | x | |
Serratia marcescens | x | x |
Non-fermenting bacteria | ||
Acinetobacter baumannii complex * | x | x |
Pseudomonas aeruginosa | x | x |
Stenotrophomonas maltophilia | x | |
Atypical bacteria | ||
Chlamydia pneumoniae | x | x |
Legionella pneumophila | x | x |
Mycoplasma pneumoniae | x | x |
Others | ||
Pneumocystis jirovecii | x | |
Resistance genes | x | x |
Virus | x | x |