SLC25A13 Gene

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1		Karina Chen	+ 556 word(s)	556	2020-12-15 08:09:38

This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/slc25a13

solute carrier family 25 member 13

genes

1. Normal Function

The SLC25A13 gene provides instructions for making a protein called citrin. This protein is active chiefly in the liver, kidneys, and heart. Within the cells of these organs, citrin is involved in transporting molecules into and out of energy-producing structures called mitochondria. Specifically, citrin carries a protein building block (amino acid) called glutamate into mitochondria and transports the amino acid aspartate out of mitochondria as part of a process called the malate-aspartate shuttle.

An adequate supply of aspartate must be transported out of mitochondria to participate in a process called the urea cycle. The urea cycle is a sequence of chemical reactions that takes place in liver cells. These reactions process excess nitrogen that is generated as the body uses proteins. The excess nitrogen is used to make a compound called urea, which is excreted from the body in urine.

Citrin participates in several other important cellular functions as part of the malate-aspartate shuttle. This protein plays a role in producing and breaking down simple sugars and making proteins. It is also involved in the production of nucleotides, which are the building blocks of DNA and its chemical cousin, RNA.

2. Health Conditions Related to Genetic Changes

2.1. Citrullinemia

More than 20 mutations in the SLC25A13 gene have been identified in people with adult-onset type II citrullinemia. This condition causes neurological problems, such as confusion, restlessness, irritability, and seizures, usually beginning in adulthood. Almost all of the identified mutations lead to the production of an unstable citrin protein that is quickly broken down or an abnormally short, nonfunctional version of the protein.

A lack of functional citrin blocks the malate-aspartate shuttle, including the transport of aspartate out of mitochondria. This loss of citrin inhibits the normal production of proteins and nucleotides. It also reduces the amount of aspartate available to take part in the urea cycle. As a result, the liver cannot effectively process excess nitrogen into urea. A disruption in the urea cycle allows nitrogen (in the form of ammonia) and other byproducts of the urea cycle (such as citrulline) to build up in the bloodstream. Ammonia is toxic, especially to the nervous system, which helps explain the development of abnormal behaviors and other neurological problems in people with adult-onset type II citrullinemia.

Mutations in the SLC25A13 gene also have been found in infants with a liver disorder called neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD). This liver disorder is also known as neonatal-onset type II citrullinemia. NICCD blocks the flow of bile (a digestive fluid produced by the liver) and prevents the body from processing certain nutrients properly. Ammonia does not build up in the bloodstream of infants with NICCD, and the signs and symptoms typically go away within a year. In rare cases, these individuals develop signs and symptoms of another condition called failure to thrive and dyslipidemia caused by citrin deficiency (FTTDCD) after recovering from NICCD. Many individuals with NICCD or FTTDCD have the same mutations in the SLC25A13 gene as people with adult-onset type II citrullinemia. Years or even decades later, some people who had NICCD or FTTDCD develop the features of adult-onset type II citrullinemia.

3. Other Names for This Gene

ARALAR2
calcium-binding mitochondrial carrier protein Aralar2
CITRIN
CMC2_HUMAN
CTLN2
mitochondrial aspartate glutamate carrier 2
solute carrier family 25 (aspartate/glutamate carrier), member 13

References

Kobayashi K, Bang Lu Y, Xian Li M, Nishi I, Hsiao KJ, Choeh K, Yang Y, Hwu WL,Reichardt JK, Palmieri F, Okano Y, Saheki T. Screening of nine SLC25A13mutations: their frequency in patients with citrin deficiency and high carrierrates in Asian populations. Mol Genet Metab. 2003 Nov;80(3):356-9.
Lu YB, Kobayashi K, Ushikai M, Tabata A, Iijima M, Li MX, Lei L, Kawabe K,Taura S, Yang Y, Liu TT, Chiang SH, Hsiao KJ, Lau YL, Tsui LC, Lee DH, Saheki T. Frequency and distribution in East Asia of 12 mutations identified in theSLC25A13 gene of Japanese patients with citrin deficiency. J Hum Genet.2005;50(7):338-346. doi: 10.1007/s10038-005-0262-8.
Saheki T, Kobayashi K, Iijima M, Horiuchi M, Begum L, Jalil MA, Li MX, Lu YB, Ushikai M, Tabata A, Moriyama M, Hsiao KJ, Yang Y. Adult-onset type IIcitrullinemia and idiopathic neonatal hepatitis caused by citrin deficiency:involvement of the aspartate glutamate carrier for urea synthesis and maintenanceof the urea cycle. Mol Genet Metab. 2004 Apr;81 Suppl 1:S20-6. Review.
Saheki T, Kobayashi K, Iijima M, Moriyama M, Yazaki M, Takei Y, Ikeda S.Metabolic derangements in deficiency of citrin, a liver-type mitochondrialaspartate-glutamate carrier. Hepatol Res. 2005 Oct;33(2):181-4.
Saheki T, Kobayashi K, Iijima M, Nishi I, Yasuda T, Yamaguchi N, Gao HZ, JalilMA, Begum L, Li MX. Pathogenesis and pathophysiology of citrin (a mitochondrialaspartate glutamate carrier) deficiency. Metab Brain Dis. 2002 Dec;17(4):335-46. Review.
Saheki T, Kobayashi K. Mitochondrial aspartate glutamate carrier (citrin)deficiency as the cause of adult-onset type II citrullinemia (CTLN2) andidiopathic neonatal hepatitis (NICCD). J Hum Genet. 2002;47(7):333-41. Review.
Song YZ, Deng M, Chen FP, Wen F, Guo L, Cao SL, Gong J, Xu H, Jiang GY, Zhong L, Kobayashi K, Saheki T, Wang ZN. Genotypic and phenotypic features of citrindeficiency: five-year experience in a Chinese pediatric center. Int J Mol Med.2011 Jul;28(1):33-40. doi: 10.3892/ijmm.2011.653.
Song YZ, Zhang ZH, Lin WX, Zhao XJ, Deng M, Ma YL, Guo L, Chen FP, Long XL, HeXL, Sunada Y, Soneda S, Nakatomi A, Dateki S, Ngu LH, Kobayashi K, Saheki T.SLC25A13 gene analysis in citrin deficiency: sixteen novel mutations in EastAsian patients, and the mutation distribution in a large pediatric cohort inChina. PLoS One. 2013 Sep 19;8(9):e74544. doi: 10.1371/journal.pone.0074544.

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Subjects: Genetics & Heredity

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Karina Chen

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Update Date: 24 Dec 2020

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