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Zhou, V. COMT Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5257 (accessed on 22 September 2026).
Zhou V. COMT Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5257. Accessed September 22, 2026.
Zhou, Vicky. "COMT Gene" Encyclopedia, https://encyclopedia.pub/entry/5257 (accessed September 22, 2026).
Zhou, V. (2020, December 24). COMT Gene. In Encyclopedia. https://encyclopedia.pub/entry/5257
Zhou, Vicky. "COMT Gene." Encyclopedia. Web. 24 December, 2020.
COMT Gene
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/comt

catechol-O-methyltransferase

genes

References

  1. Baker K, Baldeweg T, Sivagnanasundaram S, Scambler P, Skuse D. COMT Val108/158Met modifies mismatch negativity and cognitive function in 22q11 deletionsyndrome. Biol Psychiatry. 2005 Jul 1;58(1):23-31.
  2. Bearden CE, Jawad AF, Lynch DR, Monterossso JR, Sokol S, McDonald-McGinn DM,Saitta SC, Harris SE, Moss E, Wang PP, Zackai E, Emanuel BS, Simon TJ. Effects ofCOMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.Child Neuropsychol. 2005 Feb;11(1):109-17.
  3. Bearden CE, Jawad AF, Lynch DR, Sokol S, Kanes SJ, McDonald-McGinn DM, Saitta SC, Harris SE, Moss E, Wang PP, Zackai E, Emanuel BS, Simon TJ. Effects of afunctional COMT polymorphism on prefrontal cognitive function in patients with22q11.2 deletion syndrome. Am J Psychiatry. 2004 Sep;161(9):1700-2.
  4. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, HydeTM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR. Functional analysisof genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA,protein, and enzyme activity in postmortem human brain. Am J Hum Genet. 2004Nov;75(5):807-21.Jun;76(6):1089.
  5. Craddock N, Owen MJ, O'Donovan MC. The catechol-O-methyl transferase (COMT)gene as a candidate for psychiatric phenotypes: evidence and lessons. MolPsychiatry. 2006 May;11(5):446-58. Review.
  6. Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L.Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk ofschizophrenia: a large-scale association study plus meta-analysis. BiolPsychiatry. 2005 Jan 15;57(2):139-44. Review.
  7. Glaser B, Debbane M, Hinard C, Morris MA, Dahoun SP, Antonarakis SE, Eliez S. No evidence for an effect of COMT Val158Met genotype on executive function inpatients with 22q11 deletion syndrome. Am J Psychiatry. 2006 Mar;163(3):537-9.
  8. Glatt SJ, Faraone SV, Tsuang MT. Association between a functional catecholO-methyltransferase gene polymorphism and schizophrenia: meta-analysis ofcase-control and family-based studies. Am J Psychiatry. 2003 Mar;160(3):469-76.Review.
  9. Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, Kwon H, JinS, Jo B, Antonarakis SE, Morris MA, Reiss AL. COMT genotype predicts longitudinalcognitive decline and psychosis in 22q11.2 deletion syndrome. Nat Neurosci. 2005 Nov;8(11):1500-2.
  10. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, andneuropathology: on the matter of their convergence. Mol Psychiatry. 2005Jan;10(1):40-68; image 5. Review. Erratum in: Mol Psychiatry. 2005 Apr;10(4):420.Mol Psychiatry. 2005 Aug;10(8):804.
  11. Meyer-Lindenberg A, Nichols T, Callicott JH, Ding J, Kolachana B, Buckholtz J,Mattay VS, Egan M, Weinberger DR. Impact of complex genetic variation in COMT on human brain function. Mol Psychiatry. 2006 Sep;11(9):867-77, 797.
  12. Mikołajczyk E, Smiarowska M, Grzywacz A, Samochowiec J. Association of eating disorders with catechol-o-methyltransferase gene functional polymorphism.Neuropsychobiology. 2006;54(1):82-6.
  13. Savitz J, Solms M, Ramesar R. The molecular genetics of cognition: dopamine,COMT and BDNF. Genes Brain Behav. 2006 Jun;5(4):311-28. Review.
  14. Shashi V, Keshavan MS, Howard TD, Berry MN, Basehore MJ, Lewandowski E, KwapilTR. Cognitive correlates of a functional COMT polymorphism in children with22q11.2 deletion syndrome. Clin Genet. 2006 Mar;69(3):234-8.
  15. Shifman S, Bronstein M, Sternfeld M, Pisanté A, Weizman A, Reznik I, Spivak B,Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY,Shinar E, Yakir B, Zak NB, Darvasi A. COMT: a common susceptibility gene inbipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004Jul 1;128B(1):61-4.
  16. Simon TJ, Bish JP, Bearden CE, Ding L, Ferrante S, Nguyen V, Gee JC,McDonald-McGinn DM, Zackai EH, Emanuel BS. A multilevel analysis of cognitivedysfunction and psychopathology associated with chromosome 22q11.2 deletionsyndrome in children. Dev Psychopathol. 2005 Summer;17(3):753-84. Review.
  17. Williams HJ, Glaser B, Williams NM, Norton N, Zammit S, MacGregor S, Kirov GK,Owen MJ, O'Donovan MC. No association between schizophrenia and polymorphisms in COMT in two large samples. Am J Psychiatry. 2005 Sep;162(9):1736-8.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Vicky Zhou
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Update Date: 24 Dec 2020
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