Carney Complex

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Yang, C. Carney Complex. Encyclopedia. Available online: https://encyclopedia.pub/entry/5169 (accessed on 22 September 2026).

Yang C. Carney Complex. Encyclopedia. Available at: https://encyclopedia.pub/entry/5169. Accessed September 22, 2026.

Yang, Catherine. "Carney Complex" Encyclopedia, https://encyclopedia.pub/entry/5169 (accessed September 22, 2026).

Yang, C. (2020, December 24). Carney Complex. In Encyclopedia. https://encyclopedia.pub/entry/5169

Yang, Catherine. "Carney Complex." Encyclopedia. Web. 24 December, 2020.

Carney Complex

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/carney-complex

Carney complex is a disorder characterized by an increased risk of several types of tumors. Affected individuals also usually have changes in skin coloring (pigmentation). Signs and symptoms of this condition commonly begin in the teens or early adulthood.

genetic conditions

References

Bertherat J, Horvath A, Groussin L, Grabar S, Boikos S, Cazabat L, Libe R,René-Corail F, Stergiopoulos S, Bourdeau I, Bei T, Clauser E, Calender A,Kirschner LS, Bertagna X, Carney JA, Stratakis CA. Mutations in regulatorysubunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase(PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes. J Clin Endocrinol Metab. 2009 Jun;94(6):2085-91. doi: 10.1210/jc.2008-2333.
Carney JA, Gordon H, Carpenter PC, Shenoy BV, Go VL. The complex of myxomas,spotty pigmentation, and endocrine overactivity. Medicine (Baltimore). 1985Jul;64(4):270-83.
Horvath A, Bertherat J, Groussin L, Guillaud-Bataille M, Tsang K, Cazabat L,Libé R, Remmers E, René-Corail F, Faucz FR, Clauser E, Calender A, Bertagna X,Carney JA, Stratakis CA. Mutations and polymorphisms in the gene encodingregulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update. HumMutat. 2010 Apr;31(4):369-79. doi: 10.1002/humu.21178.
Horvath A, Bossis I, Giatzakis C, Levine E, Weinberg F, Meoli E,Robinson-White A, Siegel J, Soni P, Groussin L, Matyakhina L, Verma S, Remmers E,Nesterova M, Carney JA, Bertherat J, Stratakis CA. Large deletions of the PRKAR1Agene in Carney complex. Clin Cancer Res. 2008 Jan 15;14(2):388-95. doi:10.1158/1078-0432.CCR-07-1155.
Horvath A, Stratakis CA. Carney complex and lentiginosis. Pigment CellMelanoma Res. 2009 Oct;22(5):580-7. doi: 10.1111/j.1755-148X.2009.00613.x.
Kirschner LS. Use of mouse models to understand the molecular basis oftissue-specific tumorigenesis in the Carney complex. J Intern Med. 2009Jul;266(1):60-8. doi: 10.1111/j.1365-2796.2009.02114.x. Review.
Mateus C, Palangié A, Franck N, Groussin L, Bertagna X, Avril MF, Bertherat J,Dupin N. Heterogeneity of skin manifestations in patients with Carney complex. J Am Acad Dermatol. 2008 Nov;59(5):801-10. doi: 10.1016/j.jaad.2008.07.032.
Stratakis CA, Raygada M. Carney Complex. 2003 Feb 5 [updated 2018 Aug 16]. In:Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A,editors. GeneReviews® [Internet]. Seattle (WA): University of Washington,Seattle; 1993-2020. Available from http://www.ncbi.nlm.nih.gov/books/NBK1286/

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Subjects: Genetics & Heredity

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Entry Collection: MedlinePlus

Update Date: 24 Dec 2020

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