CHRNA4 Gene

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Zhou, V. CHRNA4 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5131 (accessed on 22 September 2026).

Zhou V. CHRNA4 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5131. Accessed September 22, 2026.

Zhou, Vicky. "CHRNA4 Gene" Encyclopedia, https://encyclopedia.pub/entry/5131 (accessed September 22, 2026).

Zhou, V. (2020, December 24). CHRNA4 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5131

Zhou, Vicky. "CHRNA4 Gene." Encyclopedia. Web. 24 December, 2020.

CHRNA4 Gene

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/chrna4

cholinergic receptor nicotinic alpha 4 subunit

genes

References

Arneric SP, Holladay M, Williams M. Neuronal nicotinic receptors: aperspective on two decades of drug discovery research. Biochem Pharmacol. 2007Oct 15;74(8):1092-101.
Bertrand D, Picard F, Le Hellard S, Weiland S, Favre I, Phillips H, BertrandS, Berkovic SF, Malafosse A, Mulley J. How mutations in the nAChRs can causeADNFLE epilepsy. Epilepsia. 2002;43 Suppl 5:112-22.
Bertrand S, Weiland S, Berkovic SF, Steinlein OK, Bertrand D. Properties ofneuronal nicotinic acetylcholine receptor mutants from humans suffering fromautosomal dominant nocturnal frontal lobe epilepsy. Br J Pharmacol. 1998Oct;125(4):751-60.
di Corcia G, Blasetti A, De Simone M, Verrotti A, Chiarelli F. Recent advanceson autosomal dominant nocturnal frontal lobe epilepsy: "understanding thenicotinic acetylcholine receptor (nAChR)". Eur J Paediatr Neurol.2005;9(2):59-66. Review.
Feng Y, Niu T, Xing H, Xu X, Chen C, Peng S, Wang L, Laird N, Xu X. A commonhaplotype of the nicotine acetylcholine receptor alpha 4 subunit gene isassociated with vulnerability to nicotine addiction in men. Am J Hum Genet. 2004 Jul;75(1):112-21.
Hutchison KE, Allen DL, Filbey FM, Jepson C, Lerman C, Benowitz NL, Stitzel J,Bryan A, McGeary J, Haughey HM. CHRNA4 and tobacco dependence: from generegulation to treatment outcome. Arch Gen Psychiatry. 2007 Sep;64(9):1078-86.
Kuryatov A, Gerzanich V, Nelson M, Olale F, Lindstrom J. Mutation causingautosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability,conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors. JNeurosci. 1997 Dec 1;17(23):9035-47.
Li MD, Beuten J, Ma JZ, Payne TJ, Lou XY, Garcia V, Duenes AS, Crews KM,Elston RC. Ethnic- and gender-specific association of the nicotinic acetylcholinereceptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet.2005 May 1;14(9):1211-9.
Marini C, Guerrini R. The role of the nicotinic acetylcholine receptors insleep-related epilepsy. Biochem Pharmacol. 2007 Oct 15;74(8):1308-14.
Steinlein OK, Mulley JC, Propping P, Wallace RH, Phillips HA, Sutherland GR,Scheffer IE, Berkovic SF. A missense mutation in the neuronal nicotinicacetylcholine receptor alpha 4 subunit is associated with autosomal dominantnocturnal frontal lobe epilepsy. Nat Genet. 1995 Oct;11(2):201-3.

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Subjects: Genetics & Heredity

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Update Date: 24 Dec 2020

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