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Zhou, V. CARD14 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5071 (accessed on 22 September 2026).
Zhou V. CARD14 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5071. Accessed September 22, 2026.
Zhou, Vicky. "CARD14 Gene" Encyclopedia, https://encyclopedia.pub/entry/5071 (accessed September 22, 2026).
Zhou, V. (2020, December 24). CARD14 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5071
Zhou, Vicky. "CARD14 Gene." Encyclopedia. Web. 24 December, 2020.
CARD14 Gene
Edit

caspase recruitment domain family member 14

genes

References

  1. Berki DM, Liu L, Choon SE, David Burden A, Griffiths CEM, Navarini AA, Tan ES,Irvine AD, Ranki A, Ogo T, Petrof G, Mahil SK, Duckworth M, Allen MH, Vito P,Trembath RC, McGrath J, Smith CH, Capon F, Barker JN. Activating CARD14 MutationsAre Associated with Generalized Pustular Psoriasis but Rarely Account forFamilial Recurrence in Psoriasis Vulgaris. J Invest Dermatol. 2015Dec;135(12):2964-2970. doi: 10.1038/jid.2015.288.
  2. Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S,DiStefano PS, Alnemri ES. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem. 2001 Apr 13;276(15):11877-82.
  3. Fuchs-Telem D, Sarig O, van Steensel MA, Isakov O, Israeli S, Nousbeck J,Richard K, Winnepenninckx V, Vernooij M, Shomron N, Uitto J, Fleckman P, Richard G, Sprecher E. Familial pityriasis rubra pilaris is caused by mutations inCARD14. Am J Hum Genet. 2012 Jul 13;91(1):163-70. doi:10.1016/j.ajhg.2012.05.010.
  4. Howes A, O'Sullivan PA, Breyer F, Ghose A, Cao L, Krappmann D, Bowcock AM, LeySC. Psoriasis mutations disrupt CARD14 autoinhibition promotingBCL10-MALT1-dependent NF-κB activation. Biochem J. 2016 Jun 15;473(12):1759-68.doi: 10.1042/BCJ20160270.
  5. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, StuartPE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA,Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14,encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 2012 May 4;90(5):796-808. doi: 10.1016/j.ajhg.2012.03.013.
  6. Jordan CT, Cao L, Roberson ED, Pierson KC, Yang CF, Joyce CE, Ryan C, Duan S, Helms CA, Liu Y, Chen Y, McBride AA, Hwu WL, Wu JY, Chen YT, Menter A,Goldbach-Mansky R, Lowes MA, Bowcock AM. PSORS2 is due to mutations in CARD14. AmJ Hum Genet. 2012 May 4;90(5):784-95. doi: 10.1016/j.ajhg.2012.03.012.
  7. Scudiero I, Zotti T, Ferravante A, Vessichelli M, Vito P, Stilo R. Alternativesplicing of CARMA2/CARD14 transcripts generates protein variants withdifferential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death. J Cell Physiol. 2011 Dec;226(12):3121-31. doi: 10.1002/jcp.22667.
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Update Date: 24 Dec 2020
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