Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Vicky Zhou + 634 word(s) 634 2020-12-15 07:46:08

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Zhou, V. BRCA2 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4997 (accessed on 22 September 2026).
Zhou V. BRCA2 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4997. Accessed September 22, 2026.
Zhou, Vicky. "BRCA2 Gene" Encyclopedia, https://encyclopedia.pub/entry/4997 (accessed September 22, 2026).
Zhou, V. (2020, December 24). BRCA2 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4997
Zhou, Vicky. "BRCA2 Gene." Encyclopedia. Web. 24 December, 2020.
BRCA2 Gene
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/brca2

BRCA2, DNA repair associated

genes

References

  1. Chen S, Parmigiani G. Meta-analysis of BRCA1 and BRCA2 penetrance. J ClinOncol. 2007 Apr 10;25(11):1329-33.
  2. Foulkes WD, Shuen AY. In brief: BRCA1 and BRCA2. J Pathol. 2013Aug;230(4):347-9. doi: 10.1002/path.4205. Review.
  3. Foulkes WD. BRCA1 and BRCA2 - update and implications on the genetics ofbreast cancer: a clinical perspective. Clin Genet. 2014 Jan;85(1):1-4. doi:10.1111/cge.12291.Mar;85(3):302.
  4. Friebel TM, Domchek SM, Rebbeck TR. Modifiers of cancer risk in BRCA1 andBRCA2 mutation carriers: systematic review and meta-analysis. J Natl Cancer Inst.2014 Jun;106(6):dju091. doi: 10.1093/jnci/dju091. Review. Erratum in: J NatlCancer Inst. 2014 Aug;106(8):dju235 doi:10.1093/jnci/dju235.
  5. Kobayashi H, Ohno S, Sasaki Y, Matsuura M. Hereditary breast and ovariancancer susceptibility genes (review). Oncol Rep. 2013 Sep;30(3):1019-29. doi:10.3892/or.2013.2541.
  6. National Cancer Institute: Genetics of Breast and Gynecologic Cancers (PDQ®)–Health Professional Version
  7. Nelson HD, Fu R, Goddard K, Mitchell JP, Okinaka-Hu L, Pappas M, Zakher B.Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer:Systematic Review to Update the U.S. Preventive Services Task ForceRecommendation [Internet]. Rockville (MD): Agency for Healthcare Research andQuality (US); 2013 Dec. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK179201/
  8. Pennington KP, Swisher EM. Hereditary ovarian cancer: beyond the usualsuspects. Gynecol Oncol. 2012 Feb;124(2):347-53. doi:10.1016/j.ygyno.2011.12.415. Review.
  9. Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breastand Ovarian Cancer. 1998 Sep 4 [updated 2016 Dec 15]. In: Adam MP, Ardinger HH,Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews®[Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Availablefrom http://www.ncbi.nlm.nih.gov/books/NBK1247/
  10. Shahid T, Soroka J, Kong E, Malivert L, McIlwraith MJ, Pape T, West SC, Zhang X. Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.Nat Struct Mol Biol. 2014 Nov;21(11):962-968. doi: 10.1038/nsmb.2899.
  11. Shulman LP. Hereditary breast and ovarian cancer (HBOC): clinical features andcounseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome. Obstet Gynecol Clin North Am. 2010 Mar;37(1):109-33, Table of Contents.doi: 10.1016/j.ogc.2010.03.003. Review.
  12. Toss A, Tomasello C, Razzaboni E, Contu G, Grandi G, Cagnacci A, Schilder RJ, Cortesi L. Hereditary ovarian cancer: not only BRCA 1 and 2 genes. Biomed ResInt. 2015;2015:341723. doi: 10.1155/2015/341723.
  13. Wagner JE, Tolar J, Levran O, Scholl T, Deffenbaugh A, Satagopan J, Ben-Porat L, Mah K, Batish SD, Kutler DI, MacMillan ML, Hanenberg H, Auerbach AD. Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onsetleukemia, and Fanconi anemia. Blood. 2004 Apr 15;103(8):3226-9.
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Vicky Zhou
View Times: 1.0K
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Academic Video Service
    Feedback