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Dual Oxidase 2: The DUOX2 gene provides instructions for making an enzyme called dual oxidase 2. 

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Entry Collection: MedlinePlus
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Update Time: 24 Dec 2020

1. Normal Function

This enzyme is found in the thyroid gland, which is a butterfly-shaped tissue in the lower neck. The enzyme is also found in salivary glands, the digestive tract, and airways in the throat and lungs. Dual oxidase 2 helps generate a chemical called hydrogen peroxide. In the thyroid, hydrogen peroxide is required for one of the final steps in the production of thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).

2. Health Conditions Related to Genetic Changes

2.1 Congenital Hypothyroidism

Researchers have identified several DUOX2 gene mutations that cause congenital hypothyroidism, a condition characterized by a reduction of thyroid hormone levels that is present from birth. Most of these mutations result in an abnormally small version of the dual oxidase 2 enzyme. The remaining mutations change one of the building blocks (amino acids) used to make the enzyme, which probably alters the enzyme's structure. All DUOX2 gene mutations limit the enzyme's ability to generate hydrogen peroxide. Without sufficient hydrogen peroxide, thyroid hormone production is disrupted. In some cases, the thyroid gland is enlarged (goiter) in an attempt to compensate for reduced thyroid hormone production. Because cases caused by mutations in the DUOX2 gene are due to a disruption of thyroid hormone synthesis, they are classified as thyroid dyshormonogenesis.

The reduction in thyroid hormone production is affected by the number of DUOX2 genes with a mutation. Each cell in the body has two copies of the DUOX2 gene. If both copies of the gene have a mutation, cells in the thyroid gland generate very little hydrogen peroxide. As a result, thyroid hormone levels are extremely low, causing severe congenital hypothyroidism. If only one copy of the DUOX2 gene is mutated, some hydrogen peroxide is produced. As a result, thyroid hormone levels are slightly reduced, causing mild congenital hypothyroidism. Sometimes, mild congenital hypothyroidism is temporary (transient), and thyroid hormone levels that are low during infancy increase with age.

3. Other Names for This Gene

  • DUOX2_HUMAN

  • flavoprotein NADPH oxidase

  • LNOX2

  • NADPH thyroid oxidase 2

  • nicotinamide adenine dinucleotide phosphate oxidase

  • NOXEF2

  • P138-TOX

  • THOX2

References

  1. De Deken X, Wang D, Dumont JE, Miot F. Characterization of ThOX proteins ascomponents of the thyroid H(2)O(2)-generating system. Exp Cell Res. 2002 Feb15;273(2):187-96.
  2. El Hassani RA, Benfares N, Caillou B, Talbot M, Sabourin JC, Belotte V, MorandS, Gnidehou S, Agnandji D, Ohayon R, Kaniewski J, Noël-Hudson MS, Bidart JM,Schlumberger M, Virion A, Dupuy C. Dual oxidase2 is expressed all along thedigestive tract. Am J Physiol Gastrointest Liver Physiol. 2005May;288(5):G933-42.
  3. Forteza R, Salathe M, Miot F, Forteza R, Conner GE. Regulated hydrogenperoxide production by Duox in human airway epithelial cells. Am J Respir CellMol Biol. 2005 May;32(5):462-9.
  4. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. Dual oxidases represent novelhydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003 Aug;17(11):1502-4.
  5. Jin HY, Heo SH, Kim YM, Kim GH, Choi JH, Lee BH, Yoo HW. High frequency ofDUOX2 mutations in transient or permanent congenital hypothyroidism with eutopic thyroid glands. Horm Res Paediatr. 2014;82(4):252-60. doi: 10.1159/000362235.
  6. Varela V, Rivolta CM, Esperante SA, Gruñeiro-Papendieck L, Chiesa A, TargovnikHM. Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A>C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect. ClinChem. 2006 Feb;52(2):182-91.
  7. Wang F, Lu K, Yang Z, Zhang S, Lu W, Zhang L, Liu S, Yan S. Genotypes andphenotypes of congenital goitre and hypothyroidism caused by mutations in dualoxidase 2 genes. Clin Endocrinol (Oxf). 2014 Sep;81(3):452-7. doi:10.1111/cen.12469.
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View Times: 55
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Update Time: 24 Dec 2020
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    Li, V. DUOX2 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4983 (accessed on 30 September 2022).
    Li V. DUOX2 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4983. Accessed September 30, 2022.
    Li, Vivi. "DUOX2 Gene," Encyclopedia, https://encyclopedia.pub/entry/4983 (accessed September 30, 2022).
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    Li, Vivi. ''DUOX2 Gene.'' Encyclopedia. Web. 24 December, 2020.
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