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Yin, N. Congenital Insensitivity to Pain. Encyclopedia. Available online: (accessed on 02 December 2023).
Yin N. Congenital Insensitivity to Pain. Encyclopedia. Available at: Accessed December 02, 2023.
Yin, Nicole. "Congenital Insensitivity to Pain" Encyclopedia, (accessed December 02, 2023).
Yin, N.(2020, December 24). Congenital Insensitivity to Pain. In Encyclopedia.
Yin, Nicole. "Congenital Insensitivity to Pain." Encyclopedia. Web. 24 December, 2020.
Congenital Insensitivity to Pain

Congenital insensitivity to pain is a condition that inhibits the ability to perceive physical pain.

genetic conditions

1. Itroduction

From birth, affected individuals never feel pain in any part of their body when injured. People with this condition can feel the difference between sharp and dull and hot and cold, but cannot sense, for example, that a hot beverage is burning their tongue. This lack of pain awareness often leads to an accumulation of wounds, bruises, broken bones, and other health issues that may go undetected. Young children with congenital insensitivity to pain may have mouth or finger wounds due to repeated self-biting and may also experience multiple burn-related injuries. These repeated injuries often lead to a reduced life expectancy in people with congenital insensitivity to pain. Many people with congenital insensitivity to pain also have a complete loss of the sense of smell (anosmia).

Congenital insensitivity to pain is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain.

2. Frequency

Congenital insensitivity to pain is a rare condition; about 20 cases have been reported in the scientific literature.

3. Causes

Mutations in the SCN9A gene cause congenital insensitivity to pain. The SCN9A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.7. Sodium channels transport positively charged sodium atoms (sodium ions) into cells and play a key role in a cell's ability to generate and transmit electrical signals. NaV1.7 sodium channels are found in nerve cells called nociceptors that transmit pain signals to the spinal cord and brain. The NaV1.7 channel is also found in olfactory sensory neurons, which are nerve cells in the nasal cavity that transmit smell-related signals to the brain.

The SCN9A gene mutations that cause congenital insensitivity to pain result in the production of nonfunctional alpha subunits that cannot be incorporated into NaV1.7 channels. As a result, the channels cannot be formed. The absence of NaV1.7 channels impairs the transmission of pain signals from the site of injury to the brain, causing those affected to be insensitive to pain. Loss of this channel in olfactory sensory neurons likely impairs the transmission of smell-related signals to the brain, leading to anosmia.

4. Inheritance

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

5. Other Names for This Condition

  • asymbolia for pain
  • channelopathy-associated insensitivity to pain
  • CIP
  • congenital analgesia
  • congenital indifference to pain
  • congenital pain indifference
  • indifference to pain, congenital, autosomal recessive
  • pain insensitivity, congenital


  1. Dabby R. Pain disorders and erythromelalgia caused by voltage-gated sodiumchannel mutations. Curr Neurol Neurosci Rep. 2012 Feb;12(1):76-83. doi:10.1007/s11910-011-0233-8. Review.
  2. Fischer TZ, Waxman SG. Familial pain syndromes from mutations of the NaV1.7sodium channel. Ann N Y Acad Sci. 2010 Jan;1184:196-207. doi:10.1111/j.1749-6632.2009.05110.x. Review.
  3. Lampert A, O'Reilly AO, Reeh P, Leffler A. Sodium channelopathies and pain.Pflugers Arch. 2010 Jul;460(2):249-63. doi: 10.1007/s00424-009-0779-3.
  4. Zufall F, Pyrski M, Weiss J, Leinders-Zufall T. Link between pain andolfaction in an inherited sodium channelopathy. Arch Neurol. 2012Sep;69(9):1119-23. doi: 10.1001/archneurol.2012.21. Review.
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Update Date: 24 Dec 2020