Bare Lymphocyte Syndrome Type II

Version	Summary	Created by	Modification	Content Size	Created at	Operation
1		Catherine Yang	+ 636 word(s)	636	2020-12-15 07:17:12

Cite

If you have any further questions, please contact Encyclopedia Editorial Office.

Select a Style

Yang, C. Bare Lymphocyte Syndrome Type II. Encyclopedia. Available online: https://encyclopedia.pub/entry/4925 (accessed on 26 September 2026).

Yang C. Bare Lymphocyte Syndrome Type II. Encyclopedia. Available at: https://encyclopedia.pub/entry/4925. Accessed September 26, 2026.

Yang, Catherine. "Bare Lymphocyte Syndrome Type II" Encyclopedia, https://encyclopedia.pub/entry/4925 (accessed September 26, 2026).

Yang, C. (2020, December 24). Bare Lymphocyte Syndrome Type II. In Encyclopedia. https://encyclopedia.pub/entry/4925

Yang, Catherine. "Bare Lymphocyte Syndrome Type II." Encyclopedia. Web. 24 December, 2020.

Bare Lymphocyte Syndrome Type II

Edit

This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/bare-lymphocyte-syndrome-type-ii

Bare lymphocyte syndrome type II (BLS II) is an inherited disorder of the immune system categorized as a form of combined immunodeficiency (CID). People with BLS II lack virtually all immune protection from bacteria, viruses, and fungi. They are prone to repeated and persistent infections that can be very serious or life-threatening. These infections are often caused by "opportunistic" organisms that ordinarily do not cause illness in people with a normal immune system.

genetic conditions

References

Ahmed A, Reith W, Puck JM, Cheng LE. Novel Mutation in the Class IITransactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol.2015 Aug;35(6):521-2. doi: 10.1007/s10875-015-0183-z.
Burd AL, Ingraham RH, Goldrick SE, Kroe RR, Crute JJ, Grygon CA. Assembly ofmajor histocompatibility complex (MHC) class II transcription factors:association and promoter recognition of RFX proteins. Biochemistry. 2004 Oct12;43(40):12750-60.
Garvie CW, Boss JM. Assembly of the RFX complex on the MHCII promoter: role ofRFXAP and RFXB in relieving autoinhibition of RFX5. Biochim Biophys Acta. 2008Dec;1779(12):797-804. doi: 10.1016/j.bbagrm.2008.07.012.
Gobin SJ, Peijnenburg A, van Eggermond M, van Zutphen M, van den Berg R, vanden Elsen PJ. The RFX complex is crucial for the constitutive and CIITA-mediated transactivation of MHC class I and beta2-microglobulin genes. Immunity. 1998Oct;9(4):531-41.
Saleem MA, Arkwright PD, Davies EG, Cant AJ, Veys PA. Clinical course ofpatients with major histocompatibility complex class II deficiency. Arch DisChild. 2000 Oct;83(4):356-9.
Shrestha D, Szöllosi J, Jenei A. Bare lymphocyte syndrome: an opportunity todiscover our immune system. Immunol Lett. 2012 Jan 30;141(2):147-57. doi:10.1016/j.imlet.2011.10.007.

©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Upload a video for this entry

Information

Subjects: Genetics & Heredity

Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Catherine Yang

View Times: 1.1K

Entry Collection: MedlinePlus

Update Date: 24 Dec 2020

Table of Contents

Video Upload Options

References