Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Peter Tang + 1122 word(s) 1122 2020-12-15 08:15:15

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Tang, P. Chromosome 2. Encyclopedia. Available online: https://encyclopedia.pub/entry/4920 (accessed on 25 September 2026).
Tang P. Chromosome 2. Encyclopedia. Available at: https://encyclopedia.pub/entry/4920. Accessed September 25, 2026.
Tang, Peter. "Chromosome 2" Encyclopedia, https://encyclopedia.pub/entry/4920 (accessed September 25, 2026).
Tang, P. (2020, December 24). Chromosome 2. In Encyclopedia. https://encyclopedia.pub/entry/4920
Tang, Peter. "Chromosome 2." Encyclopedia. Web. 24 December, 2020.
Chromosome 2
Edit

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 2, one copy inherited from each parent, form one of the pairs.

chromosomes & mtDNA

References

  1. Aldred MA, Sanford RO, Thomas NS, Barrow MA, Wilson LC, Brueton LA, BonagliaMC, Hennekam RC, Eng C, Dennis NR, Trembath RC. Molecular analysis of 20 patientswith 2q37.3 monosomy: definition of minimum deletion intervals for keyphenotypes. J Med Genet. 2004 Jun;41(6):433-9.
  2. Alkuraya FS, Kimonis VE, Holt L, Murata-Collins JL. A patient with a ringchromosome 2 and microdeletion of 2q detected using FISH: Further support for"ring chromosome 2 syndrome". Am J Med Genet A. 2005 Feb 1;132A(4):447-9. Review.
  3. Casas KA, Mononen TK, Mikail CN, Hassed SJ, Li S, Mulvihill JJ, Lin HJ, FalkRE. Chromosome 2q terminal deletion: report of 6 new patients and review ofphenotype-breakpoint correlations in 66 individuals. Am J Med Genet A. 2004 Nov1;130A(4):331-9.
  4. Chaabouni M, Le Merrer M, Raoul O, Prieur M, de Blois MC, Philippe A, VekemansM, Romana SP. Molecular cytogenetic analysis of five 2q37 deletions: refining thebrachydactyly candidate region. Eur J Med Genet. 2006 May-Jun;49(3):255-63.
  5. Czepulkowski B, Saunders K, Pocock C, Sadullah S. Mosaic trisomy 2 inmyelodysplastic syndromes and acute myeloblastic leukemias. Cancer GenetCytogenet. 2003 Aug;145(1):78-81.
  6. Dee SL, Clark AT, Willatt LR, Yates JR. A case of ring chromosome 2 withgrowth retardation, mild dysmorphism, and microdeletion of 2p detected usingFISH. J Med Genet. 2001 Sep;38(9):E32.
  7. Falk RE, Casas KA. Chromosome 2q37 deletion: clinical and molecular aspects.Am J Med Genet C Semin Med Genet. 2007 Nov 15;145C(4):357-71. Review.
  8. Giardino D, Finelli P, Russo S, Gottardi G, Rodeschini O, Atza MG, Natacci F, Larizza L. Small familial supernumerary ring chromosome 2: FISH characterization and genotype-phenotype correlation. Am J Med Genet. 2002 Aug 15;111(3):319-23.
  9. Heller M, Provan D, Amess JA, Dixon-McIver A. Myelodysplastic syndromeassociated with trisomy 2. Clin Lab Haematol. 2005 Aug;27(4):270-3.
  10. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P,Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, DelehauntyKD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, AliJ, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L,Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M,Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W,Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J,Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S,Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L,Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, CookLL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD,Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD,Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH,Wilson RK. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31.
  11. Leroy C, Landais E, Briault S, David A, Tassy O, Gruchy N, Delobel B, GrégoireMJ, Leheup B, Taine L, Lacombe D, Delrue MA, Toutain A, Paubel A, Mugneret F,Thauvin-Robinet C, Arpin S, Le Caignec C, Jonveaux P, Beri M, Leporrier N, Motte J, Fiquet C, Brichet O, Mozelle-Nivoix M, Sabouraud P, Golovkine N, Bednarek N,Gaillard D, Doco-Fenzy M. The 2q37-deletion syndrome: an update of the clinicalspectrum including overweight, brachydactyly and behavioural features in 14 newpatients. Eur J Hum Genet. 2013 Jun;21(6):602-12. doi: 10.1038/ejhg.2012.230.
  12. Mullegama SV, Rosenfeld JA, Orellana C, van Bon BW, Halbach S, Repnikova EA,Brick L, Li C, Dupuis L, Rosello M, Aradhya S, Stavropoulos DJ, Manickam K,Mitchell E, Hodge JC, Talkowski ME, Gusella JF, Keller K, Zonana J, Schwartz S,Pyatt RE, Waggoner DJ, Shaffer LG, Lin AE, de Vries BB, Mendoza-Londono R, Elsea SH. Reciprocal deletion and duplication at 2q23.1 indicates a role for MBD5 inautism spectrum disorder. Eur J Hum Genet. 2014 Jan;22(1):57-63. doi:10.1038/ejhg.2013.67.
  13. Ostroverkhova NV, Nazarenko SA, Rubtsov NB, Nazarenko LP, Bunina EN.Characterization of a small supernumerary ring marker derived from chromosome 2by forward and reverse chromosome painting. Am J Med Genet. 1999 Nov26;87(3):217-20. Review.
  14. Stevens-Kroef M, Poppe B, van Zelderen-Bhola S, van den Berg E, van derBlij-Philipsen M, Geurts van Kessel A, Slater R, Hamers G, Michaux L, Speleman F,Hagemeijer A. Translocation t(2;3)(p15-23;q26-27) in myeloid malignancies: reportof 21 new cases, clinical, cytogenetic and molecular genetic features. Leukemia. 2004 Jun;18(6):1108-14.
  15. Tadros S, Wang R, Waters JJ, Waterman C, Collins AL, Collinson MN, Ahn JW,Josifova D, Chetan R, Kumar A. Inherited 2q23.1 microdeletions involving the MBD5locus. Mol Genet Genomic Med. 2017 Aug 8;5(5):608-613. doi: 10.1002/mgg3.316.
  16. Talkowski ME, Mullegama SV, Rosenfeld JA, van Bon BW, Shen Y, Repnikova EA,Gastier-Foster J, Thrush DL, Kathiresan S, Ruderfer DM, Chiang C, Hanscom C,Ernst C, Lindgren AM, Morton CC, An Y, Astbury C, Brueton LA, Lichtenbelt KD,Ades LC, Fichera M, Romano C, Innis JW, Williams CA, Bartholomew D, Van Allen MI,Parikh A, Zhang L, Wu BL, Pyatt RE, Schwartz S, Shaffer LG, de Vries BB, Gusella JF, Elsea SH. Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as asingle causal locus of intellectual disability, epilepsy, and autism spectrumdisorder. Am J Hum Genet. 2011 Oct 7;89(4):551-63. doi:10.1016/j.ajhg.2011.09.011.
  17. Williams SR, Aldred MA, Der Kaloustian VM, Halal F, Gowans G, McLeod DR,Zondag S, Toriello HV, Magenis RE, Elsea SH. Haploinsufficiency of HDAC4 causesbrachydactyly mental retardation syndrome, with brachydactyly type E,developmental delays, and behavioral problems. Am J Hum Genet. 2010 Aug13;87(2):219-28. doi: 10.1016/j.ajhg.2010.07.011.
  18. Zarate YA, Fish JL. SATB2-associated syndrome: Mechanisms, phenotype, andpractical recommendations. Am J Med Genet A. 2017 Feb;173(2):327-337. doi:10.1002/ajmg.a.38022.
More
Upload a video for this entry
Information
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
View Times: 1.2K
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service