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Gao, Y.; Zhang, H.; Song, B.; Zhao, C.; Lu, Q. Electric Double Layer Based Epidermal Electronics for Healthcare. Encyclopedia. Available online: https://encyclopedia.pub/entry/49077 (accessed on 27 July 2024).
Gao Y, Zhang H, Song B, Zhao C, Lu Q. Electric Double Layer Based Epidermal Electronics for Healthcare. Encyclopedia. Available at: https://encyclopedia.pub/entry/49077. Accessed July 27, 2024.
Gao, Yuan, Hanchu Zhang, Bowen Song, Chun Zhao, Qifeng Lu. "Electric Double Layer Based Epidermal Electronics for Healthcare" Encyclopedia, https://encyclopedia.pub/entry/49077 (accessed July 27, 2024).
Gao, Y., Zhang, H., Song, B., Zhao, C., & Lu, Q. (2023, September 12). Electric Double Layer Based Epidermal Electronics for Healthcare. In Encyclopedia. https://encyclopedia.pub/entry/49077
Gao, Yuan, et al. "Electric Double Layer Based Epidermal Electronics for Healthcare." Encyclopedia. Web. 12 September, 2023.
Electric Double Layer Based Epidermal Electronics for Healthcare
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This entry is adapted from the peer-reviewed paper 10.3390/bios13080787

Epidermal electronics, an emerging interdisciplinary field, is advancing the development of flexible devices that can seamlessly integrate with the skin. These devices, especially Electric Double Layer (EDL)-based sensors, overcome the limitations of conventional electronic devices, offering high sensitivity, rapid response, and excellent stability. Especially, Electric Double Layer (EDL)-based epidermal sensors show great potential in the application of wearable electronics to detect biological signals due to their high sensitivity, fast response, and excellent stability. The advantages can be attributed to the biocompatibility of the materials, the flexibility of the devices, and the large capacitance due to the EDL effect. 

epidermal electronics electric double layer healthcare

1. Introduction

The skin, as the largest organ in the human body, serves as a critical interface for sensing environmental stimuli and extracting bioelectric signals [1]. This unique position renders it an invaluable platform for healthcare applications, disease diagnosis [2], and human-machine interaction. Consequently, the field of epidermal electronics, which focuses on the development of flexible and conformal electronic devices to monitor physiological signals from the human body, has experienced a surge of interest and growth [3].
However, conventional electronic devices often fall short in terms of flexibility [4], biocompatibility [5][6][7], and permeability [8], permeability refers to the ability of a device to allow for the natural exchange of substances, such as gases, fluids, or even ions, between the skin and the environment. This attribute is particularly important to maintain the skin’s normal functions and health, like breathing and sweat secretion, while the device is attached. Highly permeable devices can minimize the obstruction of these natural processes, reducing the potential for skin irritation or damage and improving the comfort and wearability of the device. which are essential for effective interfacing with the skin. This discrepancy leads to significant mechanical and biological mismatches [9][10]. Therefore, the pursuit of high-performance epidermal electronic devices that can efficiently collect and process a diverse range of biological signals is of paramount importance in this field [11].
Epidermal devices show great potential in health monitoring due to their inherent advantages in flexibility, biocompatibility, and permeability. These properties enable them to seamlessly conform to the skin’s surface, reducing discomfort and interference with normal skin function. Moreover, their ability to continuously monitor various physiological signals in real-time meets the escalating demand for rapid diagnostics and treatment in modern healthcare. This real-time and continuous monitoring capability of epidermal devices can potentially revolutionize healthcare by enabling early detection. A promising solution to the development of high-performance epidermal electronics involves the design and fabrication of devices based on the electrical double layer (EDL) effect [12][13]. EDLs, typically formed at the interface between electrolytes and conductors, offer substantial capacitance due to the EDL effect. In epidermal electronics, EDLs can be harnessed as tactile sensors by exploiting the capacitive characteristics contributed by the EDL capacitance formed at electrolyte-conductor interfaces [14]. These sensors can respond to both static and dynamic stimuli. Additionally, EDL-based devices can serve as biosensors to extract physiological signals with a high signal-to-noise ratio, such as electroencephalogram (EEG) and electromyography (EMG), leveraging the EDL effect. The performance of EDL-based epidermal electronic devices can be further enhanced by optimizing the materials, structures, and system designs. Furthermore, EDL-based devices can respond to mechanical stimulation, making them suitable for applications that require the detection of physical changes or movements. This feature, combined with their ability to process electrochemical signals, broadens their potential use in health monitoring and diagnostics.

2. Material Synthesis

In the field of electrochemistry, the Electric Double Layer (EDL) stands out as a molecularly thin interface separating two substances populated by electrically charged particles. These can include an electrode from a solid material and an electrolyte solution [15]. Constituted of two layers of opposite charges, the EDL is structured by the adsorption of ions on the solid surface, thereby forming one layer. Concurrently, the other layer forms within the proximate solution near the surface. Owing to the separation between these charges, the EDL possesses a remarkably high capacitance. Consequently, the EDL holds a pivotal role in affecting various physical and chemical processes unfolding at the interface.
Owning to the advantages of EDL, an EDL electrode emerges as an electrode to store electric charge at the electrolyte solution interface [16]. By their high charge density and rapid charge-discharge rates, EDLs are attractive in applications, such as electrochemical capacitors, sensors, and actuators. However, it is imperative to note that the performance relies on the factors, such as electrode material and electrolyte composition [17] as presented in Table 1.
Table 1. The representative materials for the flexible and epidermal electronics.
Material Electrical Conductivity (S/m) Mechanical Strength (MPa) Reference
Gold 4.1 × 107 120 [18]
Silver 6.3 × 107 250 [18]
Copper 5.8 × 106 210 [18]
Polyimide 1 × 10−14 50–170 [19]
PDMS 8130 1–5 [19]
PET 1 × 10−14 50–80 [19]
Polyaniline 5 20–100 [20]
Polypyrrole 40–200 30–80 [20]
PEDOT 300–1000 10–20 [20]
Galinstan 3.46 × 106 N/A [21]
Silver Nanowire 1 × 104–8 × 105 10–100 [22]
Collagen 10−6–10−4 0.1–1 [23]
Chitosan 10−5–10−4 1–5 [23]
Hyaluronic Acid ~10−3 0.05–0.5 [23]
PCL (Poly-caprolactone) 2.1 × 10−14 5–50 [24]
PLA (Polylactic acid) 10−15–10−13 40–60 [24]

2.1. Metal Based Materials

Galinstan [25] and silver nanowires (AgNW) [26] are typical representatives of metal-based materials and have emerged as prominent options offering flexibility [27], transparency [28], and biocompatibility for the devices. These materials present innovative solutions for biomedicine, wearable devices, and other related applications. In addition, a number of researches have been carried out to further enhance the material properties, such as the development of self-healing [29], shape-memory [30], and stimuli-responsive materials [31].
The use of liquid metals, such as Magnetic Liquid Metal (Fe-EGaIn) and Galinstan, enables exceptional stretchability and electrical conductivity of the devices, which are able to overcome the limitations of traditional solid metals.
Nanowires, as another representative of metal-based materials, have also shown great potential in the development of flexible, transparent, and biocompatible devices due to their excellent electrical and mechanical properties [32]. Among the various nanowires, AgNW is a notable example of nanowires that possess excellent electrical and mechanical properties while maintaining flexibility, transparency, and biocompatibility [33]. Therefore, it has been widely employed in the fabrication of transparent conductive films for flexible and wearable electronics [34][35]. 

2.2. Polymer-Based Materials

Recently, polymeric materials, such as polyimide (PI) [36], polydimethylsiloxane (PDMS) [37], and polyethylene terephthalate (PET) [38], which provide lightweight, highly flexible, and processable alternative properties, were also employed to be used as substrates and functional layers.
In 2011, Kim et al. demonstrated the feasibility of using polyimide as a substrate for the fabrication of stretchable and flexible electronic devices [39]. They successfully fabricated a transparent and stretchable conductor using a combination of graphene and a polyimide substrate. The device exhibited excellent mechanical and electrical properties, highlighting the potential of polymeric materials in the application of flexible electronics.
Their innovation in integrating thin-film transistors, temperature sensors, and strain gauges on a polyimide substrate shows the potential of the fabrication of micro and nanodevices with polymeric materials. With the employment of polymeric materials and various fabrication technologies, researchers enhanced device performance by optimizing the properties and functionality of these materials, which led to a substantial leap in the functionality and versatility of the devices.
While polymeric materials have been widely employed in flexible electronics, their low electrical conductivity poses a challenge to further enhance the device’s performance. To overcome this issue, conductive polymers such as polyaniline [40], polypyrrole [41], and poly(3,4-ethylenedioxythiophene) (PEDOT) [42] were developed. In addition, through doping these conductive polymers with other materials like carbon nanotubes, graphene, and metallic nanoparticles, researchers were able to further enhance their electrical conductivity.
To better understand the working mechanism of the EDL effect in these materials, it is important to develop theoretical and experimental methods that can capture the microscopic structure of the electrochemical interface and its working mechanisms. However, modeling and measuring the EDL structure for complex systems involving conductive polymers and their hybrid materials remains a challenge. For example, the effects of polymer chain conformation, molecular interactions, and ion solvation on EDL behavior are not fully understood. 

2.3. Bioinspired-Materials

Biomaterials have become more attractive for the application of epidermal electronics due to their high biocompatibility and degradability. Researchers have employed biomaterials to develop highly biocompatible, biodegradable flexible sensors, stimulators, drug delivery devices, and artificial neural networks [39][43][44]. Materials like silk fibroin, chitosan, and cellulose, which show potential for long-term stability and conformability with the human body [45][46][47], have been extensively investigated for their application in flexible devices. Also, hydrogel, a highly hydrated network of polymers, has been employed to develop sensors and actuators since it is able to closely mimic the properties of biological tissues [48].
The exploration of EDL phenomena in various material systems has significantly contributed to the development of next-generation electronic devices, especially for epidermal electronics. These advancements in material synthesis have been addressing some challenges in this field, such as the long-term stability of devices, signal processing and data transmission efficiency, and improving wearing comfort [49][50].

3. Device Fabrication

3.1. Subtractive Manufacturing

Subtractive manufacturing enables precise patterning of the materials and is considered a crucial technique in the fabrication of epidermal electronic devices. As researchers strive to optimize the fabrication process, it is essential to consider the unique requirements of each device. Factors such as resolution, throughput, and processing compatibility are usually taken into consideration. While each technique has its advantages and drawbacks, advancements in subtractive manufacturing, along with the development of novel hybrid and additive processes, will contribute to the development of epidermal electronic devices by enhancing their performance, functionality, and conformability with the human body.
Lithography is a versatile manufacturing technique that utilizes light to pattern the thin film. As a result, a desired shape or structure can be defined. This technique is widely used in epidermal electronics, where lithography can be applied to produce thin, flexible, and conformable devices with microstructures to monitor various physiological signals.
Laser cutting is a technique that uses a high-power laser beam to cut materials into desired patterns, with advantages in fast speed, low cost, and high accuracy. This method can also be applied to fabricate epidermal electronics that can conform to the skin and have sensing, heating, and communication functions. 

3.2. Additive Manufacturing

Inkjet printing is another method for the fabrication of epidermal electronics, enabling the precise deposition of conductive, semi-conductive, or insulating materials onto a flexible substrate. This technique uses inkjet printer nozzles to accurately eject ink droplets, forming a patterned circuit on the substrate. Despite its high resolution, cost-effectiveness, and scalability, inkjet printing faces challenges such as ink dispersion and film formation, which can hinder the creation of uniform and well-controlled layers.
Screen printing This technique is able to transfer material with a designed pattern onto a stretchable and flexible substrate using a stencil or mesh screen. In brief, the substrate is covered with the screen, which is then used to squeegee the ink through the mesh openings and onto the substrate, a circuit with the desired pattern can be realized. 
Three-dimensional (3D) printing This method can be used to fabricate three-dimensional devices layer by layer, enabling the fabrication of biocompatible electrodes and wearable electronics with complex structures. One of the 3D printing processes is Stereolithography (SLA), which converts liquid resin into solid layers by curing it with a laser, creating models, prototypes, patterns, and production parts [51]. Other 3D printing processes include fused deposition molding (FDM), and selective laser sintering (SLS), which have been used for epidermal electronics [52]. However, 3D printing is a relatively low efficiency and low resolution additive manufacturing technique. Recently, advances in multi-material and high-resolution printing have been investigated to overcome these limitations [53][54]. 3D printing is a promising technique for creating customized flexible devices that can conform to the skin’s surface and adapt to its deformation.
Aerosol jet printing is an innovative technique that employs a carrier gas to deposit a fine mist of material onto a substrate, which is then cured using a laser or other methods. This method has the advantages of high resolution, low-temperature processing, and direct writing on various substrates, and it is widely employed in the fabrication of epidermal electronics. Jing et al. demonstrated a novel approach to the fabrication of freestanding functional structures layer by layer with aerosol jet printing [55]. 
Transfer printing is a sophisticated technology that integrates additive and subtractive manufacturing techniques to enable the precise and efficient fabrication of flexible devices [56], such as stretchable strain sensors [57], radio frequency (RF) power harvesters [58], and transistors [59].

4. Integration Techniques for Rigid and Flexible Components

4.1. Interconnects for the 2D and 3D Dimensions

Interconnects serve as a critical component within the architecture of epidermal electronic devices, facilitating essential electrical connections among various components [60][61][62]. Numerous strategies exist for the realization of 2D and 3D interconnects, with printing emerging as a prevalent method [63]. To accommodate strain and bending, these interconnections can adopt an array of geometries, such as serpentine, helical, or buckled shapes.

4.2. Rigid IC Chip Bonding to Soft Substrates

This procedure entails the utilization of adhesives, solder, or other bonding agents to secure rigid chips onto flexible substrates [64][65][66]. The objective is to establish robust electrical contact, mechanical stability, and thermal compatibility. The choice of an appropriate bonding technique is pivotal to the success of this process. A variety of bonding methods are frequently employed, each presenting its own unique advantages and considerations.

4.3. Anisotropic Conductive Film (ACF) Bonding

ACF, a composite material composed of conductive particles and adhesive, serves a dual function: it provides mechanical adhesion and establishes an electrical connection between the rigid chip and the flexible substrate [67][68][69].

4.4. Epoxy-Based Bonding

Epoxy adhesives, known for their superior adhesion to a wide range of materials and high mechanical strength, are considered suitable candidates for bonding rigid chips to flexible substrates [65][70]. Depending on the specific requirements of the device, conductive epoxies or different interconnects, such as wire bonding or flip-chip methods, can be employed to achieve the electrical connection.

5. Applications of Epidermal Electronics in Diagnosis and Therapeutics

5.1. Diagnostic Applications of Epidermal Electronics

5.1.1. Mechanical Signal Monitoring

Epidermal Dielectric Layer (EDL) capacitive sensors exhibit remarkable sensitivity, a large span, and a short response time, making them an ideal solution for epidermal electronics [71][72]. These sensors have the ability to detect force and human muscle movement and adhere to human skin, thereby providing a versatile platform for various diagnostic applications in healthcare. Figure 1 shows different applications based on electrically double-layered epidermal electronics.
Biosensors 13 00787 g010 550
Figure 1. Overview of the representative application of epidermal electronics [71][73][74][75][76][77][78][79][80]. Reproduced with permission from [71][73][74][75][76][77][78][79][80].
EDL pressure sensors prove particularly valuable in prosthetic and robotic limbs, offering precise tactile feedback and control. For instance, Matsuda et al. introduced a highly stretchable sensing array capable of independently detecting pressure and strain [81]. This array was able to detect in-plane biaxial tensile deformation and pressure, thereby facilitating the monitoring of eye blinks, finger movements, and wrist pulses. 
In the fields of healthcare and fitness, EDL pressure sensors can deliver real-time feedback on body movement, posture, and muscle activation patterns [82]. This real-time data is helpful in preventing injuries, enhancing athletic performance, and facilitating the development of personalized exercise regimes. In addition, EDL pressure sensors can monitor pulse waves and blood pressure, two pivotal health indicators [49][83][84].

5.1.2. Bioelectrical Signal Monitoring

Bioelectrical signals hold paramount importance in the monitoring of human physiology and various disease states [85][86][87][88][89]. The EDL-gated FET biosensor array has emerged as an effective platform for probing ion channels and bioelectric signals of circulating tumor cells, signifying a revolutionary advancement in diagnostic procedures.
Luo et al. [89] demonstrated the significant strides made in EEG monitoring via EDL-gated FET biosensors, introducing a wearable, non-invasive methodology for capturing cerebral activity. The employment of these devices in sleep research, neurofeedback therapy, and the diagnosis and treatment of neurological conditions such as epilepsy, Alzheimer’s disease, and Parkinson’s disease is noteworthy. The research underscored high accuracy in differentiating various mental states when these devices were employed to detect cerebral activity during diverse cognitive tasks.

5.2. Therapeutic Applications of Epidermal Electronics

5.2.1. Therapeutic Applications in Robotics and Prosthetics

EDL pressure sensors can be amalgamated into robotic and prosthetic limbs to furnish precise tactile feedback and control, thereby aiding therapy and the rehabilitation process. Xu et al. [90] developed a stretchable and anti-impact iontronic pressure sensor featuring an ultra-broad linear range for biophysical monitoring and deep learning-aided knee rehabilitation. The sensor can track biophysical signals like pulse waves, muscle movements, and plantar pressure, while accurately predicting knee joint postures for improved rehabilitation post-orthopedic surgery.

5.2.2. Therapeutic Applications in Healthcare and Fitness

In healthcare and fitness, EDL pressure sensors deliver real-time feedback on body movement, posture, and muscle activation patterns. This data can help prevent injuries, enhance athletic performance, and aid in the development of customized exercise routines, thus serving therapeutic purposes.

5.2.3. Therapeutic Applications in Rehabilitation

EDL pressure sensors can support physical therapy and rehabilitation by tracking muscle and bone movements, identifying potential complications as summarized by Table 4. These results can guide clinicians in providing effective and personalized treatment for patients.
Table 4. EDL-Based Sensors and Electronics Applications.
Device Diagnostic Therapeutic References
Pressure Sensors Human muscle movement, body movement, posture, muscle activation patterns, pulse waves, and blood pressure, prosthetic and robotic limbs for tactile feedback and control
  • Assist in therapy and rehabilitation by providing tactile feedback and control for prosthetic and robotic limbs
  • Provide real-time feedback on body movement, posture, and muscle activation patterns for healthcare and fitness
  • Track muscle and bone movements and guide personalized treatments for rehabilitation
 [81][82][88][89][91][92][93][94][95][96]
Bioelectricity Ion channels and bioelectric signals
  • Control the permeability of nanopores and regulate molecular flow for drug delivery
  • Monitor the Bioelectric signal for healthcare and rehabilitation
 [90][97][98]

Furthermore, EDL-based epidermal electronics can also play a role in drug delivery. Kim et al. [97] presented research utilizing the electric double-layer effect to precisely control the permeability of nanopores and regulate molecular flow. The researchers designed an electrically gated nanoporous membrane composed of metal oxide nanotubes coated with polymers possessing different charges inside and outside the tubes. Applying an electric field caused the polymers to either repel or attract, changing the pore size and dynamically regulating the passage of molecules. The research demonstrated that this electrically gated nanoporous membrane could control drug molecule delivery precisely. The flow of drugs could be swiftly turned on or off by merely altering the electric field parameters, highlighting promising applications of electronic devices in drug therapy and controlled release.

References

  1. Yang, Y.; Cui, T.; Li, D.; Ji, S.; Chen, Z.; Shao, W.; Liu, H.; Ren, T.L. Breathable Electronic Skins for Daily Physiological Signal Monitoring. Nano-Micro Lett. 2022, 14, 161.
  2. Liu, Y.; Jain, A.; Eng, C.; Way, D.H.; Lee, K.; Bui, P.; Kanada, K.; de Oliveira Marinho, G.; Gallegos, J.; Gabriele, S.; et al. A Deep Learning System for Differential Diagnosis of Skin Diseases. Nat. Med. 2020, 26, 900–908.
  3. Han, N.; Yao, X.; Wang, Y.; Huang, W.; Niu, M.; Zhu, P.; Mao, Y. Recent Progress of Biomaterials-Based Epidermal Electronics for Healthcare Monitoring and Human-Machine Interaction. Biosensors 2023, 13, 393.
  4. Ma, Y.; Zhang, Y.; Cai, S.; Han, Z.; Liu, X.; Wang, F.; Cao, Y.; Wang, Z.; Li, H.; Chen, Y.; et al. Flexible Hybrid Electronics for Digital Healthcare. Adv. Mater. 2020, 32, 1902062.
  5. Bandodkar, A.J.; Lee, S.P.; Huang, I.; Li, W.; Wang, S.; Su, C.J.; Jeang, W.J.; Hang, T.; Mehta, S.; Nyberg, N.; et al. Sweat-Activated Biocompatible Batteries for Epidermal Electronic and Microfluidic Systems. Nat. Electron. 2020, 3, 554–562.
  6. Ye, G.; Qiu, J.; Fang, X.; Yu, T.; Xie, Y.; Zhao, Y.; Yan, D.; He, C.; Liu, N. A Lamellibranchia-Inspired Epidermal Electrode for Electrophysiology. Mater. Horiz. 2021, 8, 1047–1057.
  7. Jeong, W.; Park, Y.; Gwon, G.; Song, J.; Yoo, S.; Bae, J.; Ko, Y.H.; Choi, J.H.; Lee, S. All-Organic, Solution-Processed, Extremely Conformal, Mechanically Biocompatible, and Breathable Epidermal Electrodes. ACS Appl. Mater. Interfaces 2021, 13, 5660–5667.
  8. Ding, L.; Hang, C.; Yang, S.; Qi, J.; Dong, R.; Zhang, Y.; Sun, H.; Jiang, X. In Situ Deposition of Skin-Adhesive Liquid Metal Particles with Robust Wear Resistance for Epidermal Electronics. Nano Lett. 2022, 22, 4482–4490.
  9. Liu, G.; Sun, L.; Su, Y. Scaling Effects in the Mechanical System of the Flexible Epidermal Electronics and the Human Skin. J. Appl. Mech. 2020, 87, 081007.
  10. Nie, B.; Liu, S.; Qu, Q.; Zhang, Y.; Zhao, M.; Liu, J. Bio-Inspired Flexible Electronics for Smart E-Skin. Acta Biomater. 2022, 139, 280–295.
  11. Li, S.; Zhang, Y.; Wang, Y.; Xia, K.; Yin, Z.; Wang, H.; Zhang, M.; Liang, X.; Lu, H.; Zhu, M.; et al. Physical Sensors for Skin-Inspired Electronics. InfoMat 2020, 2, 184–211.
  12. Jia, L.; Guo, Z.H.; Li, L.; Pan, C.; Zhang, P.; Xu, F.; Pu, X.; Wang, Z.L. Electricity Generation and Self-Powered Sensing Enabled by Dynamic Electric Double Layer at Hydrogel-Dielectric Elastomer Interfaces. ACS Nano 2021, 15, 19651–19660.
  13. Wu, J. Understanding the Electric Double-Layer Structure, Capacitance, and Charging Dynamics. Chem. Rev. 2022, 122, 10821–10859.
  14. Groß, A.; Sakong, S. Modelling the Electric Double Layer at Electrode/Electrolyte Interfaces. Curr. Opin. Electrochem. 2019, 14, 1–6.
  15. Du, H.; Lin, X.; Xu, Z.; Chu, D. Electric double-layer transistors: A review of recent progress. J. Mater. Sci. 2015, 50, 5641–5673.
  16. Yao, Y.; Huang, W.; Chen, J.; Liu, X.; Bai, L.; Chen, W.; Cheng, Y.; Ping, J.; Marks, T.J.; Facchetti, A. Flexible and stretchable organic electrochemical transistors for physiological sensing devices. Adv. Mater. 2023, 2209906.
  17. Braendlein, M.; Lonjaret, T.; Leleux, P.; Badier, J.-M.; Malliaras, G.G. Voltage Amplifier Based on Organic Electrochemical Transistor. Adv. Sci. 2016, 4, 1600247.
  18. Voort, G.F.V.; Lampman, S.R.; Sander, B.R.; Anton, G.J.; Polakowski, C.; Kinson, J.; Muldoon, K.; Henry, S.D.; Scott, W.W. American Society of Materials. In ASM Handbook: Formerly Tenth Edition, Metals Handbook; ASM International: Almere, The Netherlands, 1998.
  19. Wessling, B. Scientific and Commercial Breakthrough for Organic Metals. Synth. Met. 1997, 85, 1313–1318.
  20. Kataura, H.; Kumazawa, Y.; Maniwa, Y.; Umezu, I.; Suzuki, S.; Ohtsuka, Y.; Achiba, Y. Optical Properties of Single-Wall Carbon Nanotubes. Synth. Met. 1999, 103, 2555–2558.
  21. Karcher, C.; Kocourek, V.; Schulze, D. Experimental Investigations of Electromagnetic Instabilities of Free Surfaces in a Liquid Metal Drop; International Scientific Colloquium: Hannover, Germany, 2003.
  22. Hu, L.; Choi, J.W.; Yang, Y.; Jeong, S.; La Mantia, F.; Cui, L.F.; Cui, Y. Highly conductive paper for energy-storage devices. Proc. Natl. Acad. Sci. USA 2009, 106, 21490–21494.
  23. Guo, L.; Xu, L.; Xu, Z.; Duan, G.; Wang, Y.; Cai, W.; Wang, Y.; Li, T. Response and stability improvement by fusing optimized micro-hotplatform and double layer bowl-like Nano Arrays. Sens. Actuators B Chem. 2016, 231, 450–457.
  24. Harit, T.; Malek, F.; Ameduri, B. Fluorinated polymers based on pyrazole groups for fuel cell membranes. Eur. Polym. J. 2016, 79, 72–81.
  25. Jeong, S.H.; Zhang, S.; Hjort, K.; Hilborn, J.; Wu, Z. PDMS-Based Elastomer Tuned Soft, Stretchable, and Sticky for Epidermal Electronics. Adv. Mater. 2016, 28, 5830–5836.
  26. Wang, Y.; Wang, J.; Cao, S.; Kong, D. A Stretchable and Breathable Form of Epidermal Device Based on Elastomeric Nanofibre Textiles and Silver Nanowires. J. Mater. Chem. C 2019, 7, 9748–9755.
  27. Liu, L.; Li, H.Y.; Fan, Y.J.; Chen, Y.H.; Kuang, S.Y.; Li, Z.B.; Wang, Z.L.; Zhu, G. Nanofiber-Reinforced Silver Nanowires Network as a Robust, Ultrathin, and Conformable Epidermal Electrode for Ambulatory Monitoring of Physiological Signals. Small 2019, 15, 1900755.
  28. Zhao, H.; Zhou, Y.; Cao, S.; Wang, Y.; Zhang, J.; Feng, S.; Wang, J.; Li, D.; Kong, D. Ultrastretchable and Washable Conductive Microtextiles by Coassembly of Silver Nanowires and Elastomeric Microfibers for Epidermal Human-Machine Interfaces. ACS Mater. Lett. 2021, 3, 912–920.
  29. Van Dijk, N.; van der Zwaag, S. Self-Healing Phenomena in Metals. Adv. Mater. Interfaces 2018, 5, 1800226.
  30. Kumari, S.; Dinbandhu; Abhishek, K. Study of Machinability Aspects of Shape Memory Alloys: A Critical Review. Mater. Today Proc. 2021, 44, 1336–1343.
  31. Mellerup, S.K.; Wang, S. Boron-Based Stimuli Responsive Materials. Chem. Soc. Rev. 2019, 48, 3537–3549.
  32. Gao, W.; Ota, H.; Kiriya, D.; Takei, K.; Javey, A. Flexible Electronics toward Wearable Sensing. Acc. Chem. Res. 2019, 52, 523–533.
  33. Wang, Z.; Sun, L.; Ni, Y.; Liu, L.; Xu, W. Flexible Electronics and Healthcare Applications. Front. Nanotechnol. 2021, 3, 625989.
  34. Kim, J.; Kumar, R.; Bandodkar, A.J.; Wang, J. Advanced Materials for Printed Wearable Electrochemical Devices: A Review. Adv. Electron. Mater. 2017, 3, 1600260.
  35. Wang, C.; Hwang, D.; Yu, Z.; Takei, K.; Park, J.; Chen, T.; Ma, B.; Javey, A. User-Interactive Electronic Skin for Instantaneous Pressure Visualization. Nat. Mater. 2013, 12, 899–904.
  36. Liu, Y.; Pharr, M.; Salvatore, G.A. Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring. ACS Nano 2017, 11, 9614–9635.
  37. Chen, J.; Zheng, J.; Gao, Q.; Zhang, J.; Zhang, J.; Omisore, O.M.; Wang, L.; Li, H. Polydimethylsiloxane (PDMS)-Based Flexible Resistive Strain Sensors for Wearable Applications. Appl. Sci. 2018, 8, 345.
  38. Kim, J.; Banks, A.; Cheng, H.; Xie, Z.; Xu, S.; Jang, K.I.; Lee, J.W.; Liu, Z.; Gutruf, P.; Huang, X.; et al. Epidermal Electronics with Advanced Capabilities in Near-Field Communication. Small 2015, 11, 906–912.
  39. Kim, D.H.; Lu, N.; Ma, R.; Kim, Y.S.; Kim, R.H.; Wang, S.; Wu, J.; Won, S.M.; Tao, H.; Islam, A.; et al. Epidermal Electronics. Science 2011, 333, 838–843.
  40. Park, H.; Jeong, Y.R.; Yun, J.; Hong, S.Y.; Jin, S.; Lee, S.J.; Zi, G.; Ha, J.S. Stretchable Array of Highly Sensitive Pressure Sensors Consisting of Polyaniline Nanofibers and Au-Coated Polydimethylsiloxane Micropillars. ACS Nano 2015, 9, 9974–9985.
  41. You, L.; Shi, X.; Cheng, J.; Yang, J.; Xiong, C.; Ding, Z.; Zheng, Z.; Wang, S.; Wang, J. Flexible Porous Gelatin/Polypyrrole/Reduction Graphene Oxide Organohydrogel for Wearable Electronics. J. Colloid Interface Sci. 2022, 625, 197–209.
  42. Fan, X.; Nie, W.; Tsai, H.; Wang, N.; Huang, H.; Cheng, Y.; Wen, R.; Ma, L.; Yan, F.; Xia, Y. PEDOT: PSS for Flexible and Stretchable Electronics: Modifications, Strategies, and Applications. Adv. Sci. 2019, 6, 1900813.
  43. Namsheer, K.; Rout, C.S. Conducting Polymers: A Comprehensive Review on Recent Advances in Synthesis, Properties and Applications. RSC Adv. 2021, 11, 5659–5697.
  44. Chen, S.; Sun, L.; Zhou, X.; Guo, Y.; Song, J.; Qian, S.; Liu, Z.; Guan, Q.; Meade Jeffries, E.; Liu, W.; et al. Mechanically and Biologically Skin-like Elastomers for Bio-Integrated Electronics. Nat. Commun. 2020, 11, 1107.
  45. Wen, D.-L.; Sun, D.-H.; Huang, P.; Huang, W.; Su, M.; Wang, Y.; Han, M.D.; Kim, B.; Brugger, J.; Zhang, H.X.; et al. Recent Progress in Silk Fibroin-Based Flexible Electronics. Microsyst. Nanoeng. 2021, 7, 35.
  46. Chen, H.; Zeng, S.; Chen, M.; Zhang, Y.; Li, Q. Fabrication and Functionalization of Carbon Nanotube Films for High-Performance Flexible Supercapacitors. Carbon 2015, 92, 271–296.
  47. Tao, H.; Kaplan, D.L.; Omenetto, F.G. Silk Materials-A Road to Sustainable High Technology. Adv. Mater. 2012, 24, 2824–2837.
  48. Yuk, H.; Lu, B.; Lin, S.; Qu, K.; Xu, J.; Luo, J.; Zhao, X. 3D Printing of Conducting Polymers. Nat. Commun. 2020, 11, 1604.
  49. Narla, V.K.; Tripathi, D. Electroosmosis Modulated Transient Blood Flow in Curved Microvessels: Study of a Mathematical Model. Microvasc. Res. 2019, 123, 25–34.
  50. Wu, Y.; Cao, J.P.; Zhao, X.Y.; Zhuang, Q.Q.; Zhou, Z.; Huang, Y.; Wei, X.Y. High-Performance Electrode Material for Electric Double-Layer Capacitor Based on Hydrothermal Pre-Treatment of Lignin by ZnCl2. Appl. Surf. Sci. 2020, 508, 144536.
  51. Bártolo, P.J. Stereolithography: Materials, Processes and Applications; Springer Science & Business Media: Berlin/Heidelberg, Germany; ISBN 978-0-387-92904-0.
  52. Huang, Z.; Hao, Y.; Li, Y.; Hu, H.; Wang, C.; Nomoto, A.; Pan, T.; Gu, Y.; Chen, Y.; Zhang, T.; et al. Three-Dimensional Integrated Stretchable Electronics. Nat. Electron. 2018, 1, 473–480.
  53. Hensleigh, R.; Cui, H.; Xu, Z.; Massman, J.; Yao, D.; Berrigan, J.; Zheng, X. Charge-Programmed Three-Dimensional Printing for Multi-Material Electronic Devices. Nat. Electron. 2020, 3, 216–224.
  54. Kalkal, A.; Kumar, S.; Kumar, P.; Pradhan, R.; Willander, M.; Packirisamy, G.; Kumar, S.; Malhotra, B.D. Recent Advances in 3D Printing Technologies for Wearable (Bio)Sensors. Addit. Manuf. 2021, 46, 102088.
  55. Jing, Q.; Choi, Y.S.; Smith, M.; Ou, C.; Busolo, T.; Kar-Narayan, S. Freestanding Functional Structures by Aerosol-Jet Printing for Stretchable Electronics and Sensing Applications. Adv. Mater. Technol. 2019, 4, 1900048.
  56. Yeo, W.H.; Kim, Y.S.; Lee, J.; Ameen, A.; Shi, L.; Li, M.; Wang, S.; Ma, R.; Jin, S.H.; Kang, Z.; et al. Multifunctional Epidermal Electronics Printed Directly Onto the Skin. Adv. Mater. 2013, 25, 2773–2778.
  57. Park, J.; Lee, Y.; Lee, H.; Ko, H. Transfer Printing of Electronic Functions on Arbitrary Complex Surfaces. ACS Nano 2020, 14, 12–20.
  58. Linghu, C.; Zhang, S.; Wang, C.; Song, J. Transfer Printing Techniques for Flexible and Stretchable Inorganic Electronics. NPJ Flex. Electron. 2018, 2, 26.
  59. Jeong, J.W.; Yang, S.R.; Hur, Y.H.; Kim, S.W.; Baek, K.M.; Yim, S.; Jang, H.I.; Park, J.H.; Lee, S.Y.; Park, C.O.; et al. High-Resolution Nanotransfer Printing Applicable to Diverse Surfaces via Interface-Targeted Adhesion Switching. Nat. Commun. 2014, 5, 5387.
  60. Jang, K.I.; Li, K.; Chung, H.U.; Xu, S.; Jung, H.N.; Yang, Y.; Kwak, J.W.; Jung, H.H.; Song, J.; Yang, C.; et al. Self-Assembled Three Dimensional Network Designs for Soft Electronics. Nat. Commun. 2017, 8, 15894.
  61. Fan, J.A.; Yeo, W.H.; Su, Y.; Hattori, Y.; Lee, W.; Jung, S.Y.; Zhang, Y.; Liu, Z.; Cheng, H.; Falgout, L.; et al. Fractal Design Concepts for Stretchable Electronics. Nat. Commun. 2014, 5, 3266.
  62. Xu, S.; Yan, Z.; Jang, K.I.; Huang, W.; Fu, H.; Kim, J.; Wei, Z.; Flavin, M.; McCracken, J.; Wang, R.; et al. Assembly of Micro/Nanomaterials into Complex, Three-Dimensional Architectures by Compressive Buckling. Science 2015, 347, 154–159.
  63. Park, Y.G.; An, H.S.; Kim, J.Y.; Park, J.U. High-Resolution, Reconfigurable Printing of Liquid Metals with Three-Dimensional Structures. Sci. Adv. 2021, 5, eaaw2844.
  64. Zhao, D.; Zhao, J.; Liu, L.; Guo, W.; Zhu, K.; Yang, G.; Li, Z.; Wu, H. Flexible Hybrid Integration Enabled xsOn-Skin Electronics for Wireless Monitoring of Electrophysiology and Motion. IEEE Trans. Biomed. Eng. 2022, 69, 1340–1348.
  65. Lee, B.; Cho, H.; Jeong, S.; Yoon, J.; Jang, D.; Lee, D.K.; Kim, D.; Chung, S.; Hong, Y. Stretchable Hybrid Electronics: Combining Rigid Electronic Devices with Stretchable Interconnects into High-Performance on-Skin Electronics. J. Inf. Disp. 2022, 23, 163–184.
  66. Wu, H.; Huang, Y.; Yin, Z. Flexible Hybrid Electronics: Enabling Integration Techniques and Applications. Sci. China Technol. Sci. 2022, 65, 1995–2006.
  67. Malik, M.H.; Grosso, G.; Zangl, H.; Binder, A.; Roshanghias, A. Flip Chip Integration of Ultra-Thinned Dies in Low-Cost Flexible Printed Electronics; the Effects of Die Thickness, Encapsulation and Conductive Adhesives. Microelectron. Reliab. 2021, 123, 114204.
  68. Lu, T.; Wissman, J.; Ruthika; Majidi, C. Soft Anisotropic Conductors as Electric Vias for Ga-Based Liquid Metal Circuits. ACS Appl. Mater. Interfaces 2015, 7, 26923–26929.
  69. Hwang, H.; Kong, M.; Kim, K.; Park, D.; Lee, S.; Park, S.; Song, H.J.; Jeong, U. Stretchable Anisotropic Conductive Film (S-ACF) for Electrical Interfacing in High-Resolution Stretchable Circuits. Sci. Adv. 2021, 7, eabh0171.
  70. Lin, L.; Dautta, M.; Hajiaghajani, A.; Escobar, A.R.; Tseng, P.; Khine, M. Paint-On Epidermal Electronics for On-Demand Sensors and Circuits. Adv. Electron. Mater. 2021, 7, 2000765.
  71. Li, P.; Xie, L.; Su, M.; Wang, P.; Yuan, W.; Dong, C.; Yang, J. Skin-Inspired Large Area Iontronic Pressure Sensor with Ultra-Broad Range and High Sensitivity. Nano Energy 2022, 101, 107571.
  72. Zheng, W.; Zhao, Y.; Xu, H.; Yuan, Y.; Wang, W.; Gao, L. Stretchable Iontronic Pressure Sensor Array With Low Crosstalk and High Sensitivity for Epidermal Monitoring. IEEE Electron Device Lett. 2023, 44, 516–519.
  73. Li, L.; Zhu, G.; Wang, J.; Chen, J.; Zhao, G.; Zhu, Y. A Flexible and Ultrasensitive Interfacial Iontronic Multisensory Sensor with an Array of Unique “Cup-Shaped” Microcolumns for Detecting Pressure and Temperature. Nano Energy 2023, 105, 108012.
  74. Regmi, A.; Sarangadharan, I.; Chen, Y.W.; Hsu, C.P.; Lee, G.Y.; Chyi, J.I.; Shiesh, S.C.; Lee, G.B.; Wang, Y.L. Direct Detection of Fibrinogen in Human Plasma Using Electric-Double-Layer Gated AlGaN/GaN High Electron Mobility Transistors. Appl. Phys. Lett. 2017, 111, 082106.
  75. Li, D.; Yao, K.; Gao, Z.; Liu, Y.; Yu, X. Recent Progress of Skin-Integrated Electronics for Intelligent Sensing. Light Adv. Manuf. 2021, 2, 39–58.
  76. Mo, L.; Ma, X.; Fan, L.; Xin, J.H.; Yu, H. Weavable, Large-Scaled, Rapid Response, Long-Term Stable Electrochemical Fabric Sensor Integrated into Clothing for Monitoring Potassium Ions in Sweat. Chem. Eng. J. 2023, 454, 140473.
  77. Song, Y.; Min, J.; Gao, W. Wearable and Implantable Electronics: Moving toward Precision Therapy. ACS Nano 2019, 13, 12280–12286.
  78. Huang, C.; Hao, Z.; Qi, T.; Pan, Y.; Zhao, X. An Integrated Flexible and Reusable Graphene Field Effect Transistor Nanosensor for Monitoring Glucose. J. Mater. 2020, 6, 308–314.
  79. Constantinescu, G.; Jeong, J.W.; Li, X.; Scott, D.K.; Jang, K.I.; Chung, H.J.; Rogers, J.A.; Rieger, J. Epidermal Electronics for Electromyography: An Application to Swallowing Therapy. Med. Eng. Phys. 2016, 38, 807–812.
  80. Wu, H.; Yang, G.; Zhu, K.; Liu, S.; Guo, W.; Jiang, Z.; Li, Z. Materials, Devices, and Systems of On-Skin Electrodes for Electrophysiological Monitoring and Human-Machine Interfaces. Adv. Sci. 2021, 8, 2001938.
  81. Matsuda, R.; Mizuguchi, S.; Nakamura, F.; Endo, T.; Isoda, Y.; Inamori, G.; Ota, H. Highly Stretchable Sensing Array for Independent Detection of Pressure and Strain Exploiting Structural and Resistive Control. Sci. Rep. 2020, 10, 12666.
  82. Meng, K.; Xiao, X.; Wei, W.; Chen, G.; Nashalian, A.; Shen, S.; Xiao, X.; Chen, J. Wearable Pressure Sensors for Pulse Wave Monitoring. Adv. Mater. 2022, 34, 2109357.
  83. Liu, X.; Wei, Y.; Qiu, Y. Advanced Flexible Skin-Like Pressure and Strain Sensors for Human Health Monitoring. Micromachines. 2021, 12, 695.
  84. Lin, Q.; Huang, J.; Yang, J.; Huang, Y.; Zhang, Y.; Wang, Y.; Zhang, J.; Wang, Y.; Yuan, L.; Cai, M.; et al. Highly Sensitive Flexible Iontronic Pressure Sensor for Fingertip Pulse Monitoring. Adv. Healthc. Mater. 2020, 9, 2001023.
  85. Graf, M.; Lihter, M.; Unuchek, D.; Sarathy, A.; Leburton, J.P.; Kis, A.; Radenovic, A. Light-Enhanced Blue Energy Generation Using MoS2 Nanopores. Joule 2019, 3, 1549–1564.
  86. Pulikkathodi, A.K.; Sarangadharan, I.; Chen, Y.H.; Lee, G.B.; Wang, Y.L. EDL Gated FET Biosensor Array for the Investigation of Ion Channels and Bioelectric Signals of Circulating Tumor Cells. ECS Trans. 2018, 85, 15.
  87. Pulikkathodi, A.K.; Sarangadharan, I.; Chen, Y.H.; Lee, G.Y.; Chyi, J.I.; Lee, G.-B.; Wang, Y.L. Dynamic Monitoring of Transmembrane Potential Changes: A Study of Ion Channels Using an Electrical Double Layer-Gated FET Biosensor. Lab A Chip 2018, 18, 1047–1056.
  88. Moreddu, R.; Boschi, A.; d’Amora, M.; Hubarevich, A.; Dipalo, M.; De Angelis, F. Passive Recording of Bioelectrical Signals from Non-Excitable Cells by Fluorescent Mirroring. Nano Lett. 2023, 23, 3217–3223.
  89. Luo, J.; Xing, Y.; Sun, C.; Fan, L.; Shi, H.; Zhang, Q.; Li, Y.; Hou, C.; Wang, H. A Bio-Adhesive Ion-Conducting Organohydrogel as a High-Performance Non-Invasive Interface for Bioelectronics. Chem. Eng. J. 2022, 427, 130886.
  90. Xu, H.; Gao, L.; Zhao, H.; Huang, H.; Wang, Y.; Chen, G.; Qin, Y.; Zhao, N.; Xu, D.; Duan, L.; et al. Stretchable and Anti-Impact Iontronic Pressure Sensor with an Ultrabroad Linear Range for Biophysical Monitoring and Deep Learning-Aided Knee Rehabilitation. Microsyst. Nanoeng. 2021, 7, 92.
  91. Lu, P.; Wang, L.; Zhu, P.; Huang, J.; Wang, Y.; Bai, N.; Wang, Y.; Li, G.; Yang, J.; Xie, K.; et al. Iontronic Pressure Sensor with High Sensitivity and Linear Response over a Wide Pressure Range Based on Soft Micropillared Electrodes. Sci. Bull. 2021, 66, 1091–1100.
  92. Su, Q.; Zou, Q.; Li, Y.; Chen, Y.; Teng, S.Y.; Kelleher, J.T.; Nith, R.; Cheng, P.; Li, N.; Liu, W.; et al. A Stretchable and Strain-Unperturbed Pressure Sensor for Motion Interference-Free Tactile Monitoring on Skins. Sci. Adv. 2021, 7, eabi4563.
  93. Li, R.; Si, Y.; Zhu, Z.; Guo, Y.; Zhang, Y.; Pan, N.; Sun, G.; Pan, T. Supercapacitive Iontronic Nanofabric Sensing. Adv. Mater. 2017, 29, 1700253.
  94. Xue, H.; Li, F.; Zhao, H.; Lin, X.; Zhang, T. A Paper-Based Iontronic Capacitive Pressure Sensor for Human Muscle Motion Monitoring. IEEE Electron Device Lett. 2022, 43, 2165–2168.
  95. Pulikkathodi, A.K.; Sarangadharan, I.; Chen, Y.H.; Lee, G.Y.; Chyi, J.I.; Lee, G.B.; Wang, Y.L. A Comprehensive Model for Whole Cell Sensing and Transmembrane Potential Measurement Using FET Biosensors. ECS J. Solid State Sci. Technol. 2018, 7, Q3001.
  96. Huang, K.-H.; Tan, F.; Wang, T.D.; Yang, Y.J. A Highly Sensitive Pressure-Sensing Array for Blood Pressure Estimation Assisted by Machine-Learning Techniques. Sensors 2019, 19, 848.
  97. Kim, S.; Ozalp, E.I.; Darwish, M.; Weldon, J.A. Electrically gated nanoporous membranes for smart molecular flow control. Nanoscale 2018, 10, 20740–20747.
  98. Nie, B.; Li, R.; Cao, J.; Brandt, J.D.; Pan, T. Flexible Transparent Iontronic Film for Interfacial Capacitive Pressure Sensing. Adv. Mater. 2015, 27, 6055–6062.
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Subjects: Materials Science, Biomaterials
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Yuan Gao
,
Hanchu Zhang
,
Bowen Song
,
Chun Zhao
,
Qifeng Lu
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Revisions: 2 times (View History)
Update Date: 13 Sep 2023
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