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Yang, C. Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy. Encyclopedia. Available online: https://encyclopedia.pub/entry/4889 (accessed on 22 September 2026).
Yang C. Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy. Encyclopedia. Available at: https://encyclopedia.pub/entry/4889. Accessed September 22, 2026.
Yang, Catherine. "Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy" Encyclopedia, https://encyclopedia.pub/entry/4889 (accessed September 22, 2026).
Yang, C. (2020, December 24). Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy. In Encyclopedia. https://encyclopedia.pub/entry/4889
Yang, Catherine. "Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy." Encyclopedia. Web. 24 December, 2020.
Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy
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Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited condition that affects many of the body's organs. It is one of many autoimmune diseases, which are disorders that occur when the immune system malfunctions and attacks the body's own tissues and organs by mistake.

genetic conditions

References

  1. Constantine GM, Lionakis MS. Lessons from primary immunodeficiencies:Autoimmune regulator and autoimmune polyendocrinopathy-candidiasis-ectodermaldystrophy. Immunol Rev. 2019 Jan;287(1):103-120. doi: 10.1111/imr.12714. Review.
  2. De Martino L, Capalbo D, Improda N, D'Elia F, Di Mase R, D'Assante R, D'AcunzoI, Pignata C, Salerno M. APECED: A Paradigm of Complex Interactions betweenGenetic Background and Susceptibility Factors. Front Immunol. 2013 Oct 23;4:331. doi: 10.3389/fimmu.2013.00331. Review.
  3. De Martino L, Capalbo D, Improda N, Lorello P, Ungaro C, Di Mase R, Cirillo E,Pignata C, Salerno M. Novel Findings into AIRE Genetics and Functioning: ClinicalImplications. Front Pediatr. 2016 Aug 22;4:86. doi: 10.3389/fped.2016.00086.
  4. DeVoss JJ, Anderson MS. Lessons on immune tolerance from the monogenic diseaseAPS1. Curr Opin Genet Dev. 2007 Jun;17(3):193-200.
  5. Ferre EM, Rose SR, Rosenzweig SD, Burbelo PD, Romito KR, Niemela JE, Rosen LB,Break TJ, Gu W, Hunsberger S, Browne SK, Hsu AP, Rampertaap S, Swamydas M, CollarAL, Kong HH, Lee CR, Chascsa D, Simcox T, Pham A, Bondici A, Natarajan M, MonsaleJ, Kleiner DE, Quezado M, Alevizos I, Moutsopoulos NM, Yockey L, Frein C,Soldatos A, Calvo KR, Adjemian J, Similuk MN, Lang DM, Stone KD, Uzel G, Kopp JB,Bishop RJ, Holland SM, Olivier KN, Fleisher TA, Heller T, Winer KK, Lionakis MS. Redefined clinical features and diagnostic criteria in autoimmunepolyendocrinopathy-candidiasis-ectodermal dystrophy. JCI Insight. 2016 Aug18;1(13). pii: e88782.
  6. Gallo V, Giardino G, Capalbo D, Palamaro L, Romano R, Santamaria F, Maio F,Salerno M, Vajro P, Pignata C. Alterations of the autoimmune regulatortranscription factor and failure of central tolerance: APECED as a model. Expert Rev Clin Immunol. 2013 Jan;9(1):43-51. doi: 10.1586/eci.12.88. Review.
  7. Kisand K, Bøe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E,Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R,Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Ströbel P, Leite MI,Battelino T, Husebye ES, Peterson P, Willcox N, Meager A. Chronic mucocutaneouscandidiasis in APECED or thymoma patients correlates with autoimmunity toTh17-associated cytokines. J Exp Med. 2010 Feb 15;207(2):299-308. doi:10.1084/jem.20091669.
  8. Kisand K, Peterson P. Autoimmune polyendocrinopathy candidiasis ectodermaldystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. Curr OpinPediatr. 2013 Dec;25(6):715-21. doi: 10.1097/MOP.0000000000000028. Review.
  9. Kisand K, Peterson P. Autoimmune polyendocrinopathy candidiasis ectodermaldystrophy. J Clin Immunol. 2015 Jul;35(5):463-78. doi: 10.1007/s10875-015-0176-y.
  10. Oftedal BE, Hellesen A, Erichsen MM, Bratland E, Vardi A, Perheentupa J, Kemp EH, Fiskerstrand T, Viken MK, Weetman AP, Fleishman SJ, Banka S, Newman WG,Sewell WA, Sozaeva LS, Zayats T, Haugarvoll K, Orlova EM, Haavik J, Johansson S, Knappskog PM, Løvås K, Wolff AS, Abramson J, Husebye ES. Dominant Mutations inthe Autoimmune Regulator AIRE Are Associated with Common Organ-SpecificAutoimmune Diseases. Immunity. 2015 Jun 16;42(6):1185-96. doi:10.1016/j.immuni.2015.04.021.
  11. Puel A, Döffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C,Cobat A, Ouachée-Chardin M, Toulon A, Bustamante J, Al-Muhsen S, Al-Owain M,Arkwright PD, Costigan C, McConnell V, Cant AJ, Abinun M, Polak M, Bougnères PF, Kumararatne D, Marodi L, Nahum A, Roifman C, Blanche S, Fischer A, Bodemer C,Abel L, Lilic D, Casanova JL. Autoantibodies against IL-17A, IL-17F, and IL-22 inpatients with chronic mucocutaneous candidiasis and autoimmune polyendocrinesyndrome type I. J Exp Med. 2010 Feb 15;207(2):291-7. doi: 10.1084/jem.20091983.
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