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Yang, C. Ankylosing Spondylitis. Encyclopedia. Available online: https://encyclopedia.pub/entry/4743 (accessed on 20 September 2026).
Yang C. Ankylosing Spondylitis. Encyclopedia. Available at: https://encyclopedia.pub/entry/4743. Accessed September 20, 2026.
Yang, Catherine. "Ankylosing Spondylitis" Encyclopedia, https://encyclopedia.pub/entry/4743 (accessed September 20, 2026).
Yang, C. (2020, December 24). Ankylosing Spondylitis. In Encyclopedia. https://encyclopedia.pub/entry/4743
Yang, Catherine. "Ankylosing Spondylitis." Encyclopedia. Web. 24 December, 2020.
Ankylosing Spondylitis
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/ankylosing-spondylitis

Ankylosing spondylitis is a form of ongoing joint inflammation (chronic inflammatory arthritis) that primarily affects the spine. This condition is characterized by back pain and stiffness that typically appear in adolescence or early adulthood. Over time, back movement gradually becomes limited as the bones of the spine (vertebrae) fuse together. This progressive bony fusion is called ankylosis.

genetic conditions

References

  1. Brown MA. Breakthroughs in genetic studies of ankylosing spondylitis.Rheumatology (Oxford). 2008 Feb;47(2):132-7.
  2. Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, Liang MH,Kremers HM, Mayes MD, Merkel PA, Pillemer SR, Reveille JD, Stone JH; NationalArthritis Data Workgroup. Estimates of the prevalence of arthritis and otherrheumatic conditions in the United States. Part I. Arthritis Rheum. 2008Jan;58(1):15-25. doi: 10.1002/art.23177.
  3. Khan MA. HLA-B27 and its pathogenic role. J Clin Rheumatol. 2008Feb;14(1):50-2. doi: 10.1097/RHU.0b013e3181637a38. Review.
  4. Khan MA. Polymorphism of HLA-B27: 105 subtypes currently known. Curr RheumatolRep. 2013 Oct;15(10):362. doi: 10.1007/s11926-013-0362-y. Review.
  5. Kim TH, Uhm WS, Inman RD. Pathogenesis of ankylosing spondylitis and reactive arthritis. Curr Opin Rheumatol. 2005 Jul;17(4):400-5. Review.
  6. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG. Ankylosing spondylitis susceptibilityloci defined by genome-search meta-analysis. J Hum Genet. 2005;50(9):453-459.doi: 10.1007/s10038-005-0277-1.
  7. Martin TM, Zhang G, Luo J, Jin L, Doyle TM, Rajska BM, Coffman JE, Smith JR,Becker MD, Mackensen F, Khan MA, Levinson RD, Schumacher HR, Wade NK, RosenbaumJT, Reveille JD. A locus on chromosome 9p predisposes to a specific diseasemanifestation, acute anterior uveitis, in ankylosing spondylitis, a geneticallycomplex, multisystem, inflammatory disease. Arthritis Rheum. 2005Jan;52(1):269-74.
  8. Reveille JD. The genetic basis of ankylosing spondylitis. Curr Opin Rheumatol.2006 Jul;18(4):332-41. Review.
  9. Robinson PC, Brown MA. Genetics of ankylosing spondylitis. Mol Immunol. 2014Jan;57(1):2-11. doi: 10.1016/j.molimm.2013.06.013.
  10. Shamji MF, Bafaquh M, Tsai E. The pathogenesis of ankylosing spondylitis.Neurosurg Focus. 2008;24(1):E3. doi: 10.3171/FOC/2008/24/1/E3. Review.
  11. Sims AM, Wordsworth BP, Brown MA. Genetic susceptibility to ankylosingspondylitis. Curr Mol Med. 2004 Feb;4(1):13-20. Review.
  12. Zhang G, Luo J, Bruckel J, Weisman MA, Schumacher HR, Khan MA, Inman RD,Mahowald M, Maksymowych WP, Martin TM, Yu DT, Stone M, Rosenbaum JT, Newman P,Lee J, McClain JA, West OC, Jin L, Reveille JD. Genetic studies in familialankylosing spondylitis susceptibility. Arthritis Rheum. 2004 Jul;50(7):2246-54.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Catherine Yang
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Entry Collection: MedlinePlus
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Update Date: 24 Dec 2020
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