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Li, K.; Wu, F.; Chen, M.; Xiao, Z.; Xu, Y.; Xu, M.; Liu, J.; Xu, D. Identification of Secondary Metabolites in Medicinal Orchids. Encyclopedia. Available online: https://encyclopedia.pub/entry/47025 (accessed on 05 December 2025).
Li K, Wu F, Chen M, Xiao Z, Xu Y, Xu M, et al. Identification of Secondary Metabolites in Medicinal Orchids. Encyclopedia. Available at: https://encyclopedia.pub/entry/47025. Accessed December 05, 2025.
Li, Kunqian, Fengju Wu, Mengzhu Chen, Zhihao Xiao, Ya Xu, Mengwei Xu, Jingyi Liu, Delin Xu. "Identification of Secondary Metabolites in Medicinal Orchids" Encyclopedia, https://encyclopedia.pub/entry/47025 (accessed December 05, 2025).
Li, K., Wu, F., Chen, M., Xiao, Z., Xu, Y., Xu, M., Liu, J., & Xu, D. (2023, July 20). Identification of Secondary Metabolites in Medicinal Orchids. In Encyclopedia. https://encyclopedia.pub/entry/47025
Li, Kunqian, et al. "Identification of Secondary Metabolites in Medicinal Orchids." Encyclopedia. Web. 20 July, 2023.
Identification of Secondary Metabolites in Medicinal Orchids
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This entry is adapted from the peer-reviewed paper 10.3390/metabo13070829

The secondary metabolites present in medicinal orchids are diverse and possess a vast array of biological activities. They represent valuable raw materials for modern pharmaceuticals and clinical medicine and have tremendous potential for future development. A systematic collation of secondary metabolites’ composition and a summary of the biological activities of medicinal orchids represent a crucial step in unlocking the potential of these valuable resources in drug development.

medicinal orchid metabolite biosynthesis chemical identification

1. Introduction

Orchids have a long history of medicinal use in China due to their cultivation for over 2000 years. The orchid family is diverse, and so far, over 28,000 species have been identified in 736 genera [1]. In the 2020 edition of the Chinese Pharmacopoeia, several species were recorded as Chinese herbal medicines (CHM). These include Gastrodia elata, Bletilla striata, Dendrobium nobile, D. huoshanense, D. chrysotoxum, D. fimbriatum, D. officinale, Cremastra appendiculata, Dendrobium spp., Pleione bulbocodioides and P. yunnanensis. In China, wild orchids have a long history as medicinal and ornamental plants. Due to their ability to treat diseases and enhance beauty and health, orchids have now become a new economic crop in agriculture. The development of orchids has resulted in several social benefits, particularly in promoting “green and natural” dietary options and daily essentials, including decoction pieces, oral liquids, beauty products, and skincare solutions. Moreover, the active elements identified in orchid plants can be leveraged to formulate new drugs. These genera include Bletilla, Anoectochilus, Liparis and several others. Research findings have shown that the types and quantities of the secondary metabolites present in CHM are known to play a significant role in their pharmacological effects and medicinal quality [2]. To effectively utilize medicinal orchid resources, it is particularly important to excavate their secondary metabolites.
In recent years, secondary metabolites have gained public attention due to their diverse biological activities and pharmacological effects, making them promising candidates for developing new drugs for stubborn diseases. The secondary metabolites found in medicinal orchids are small-molecule substances with various characteristics, including diversity, high specificity and rich biological functions. This makes them a potential source of highly specific active substances to treat stubborn diseases. However, research on medicinal orchids primarily focuses on species identification, classification, conservation and cultivation, as well as compound identification. More attention needs to be paid to the analysis and use of active substances derived from secondary metabolites, which are still in early stages. Despite their potential, medicinal orchids face natural limitations, such as their growth cycle, season, climate and natural accumulation of compounds, resulting in a situation similar to paclitaxel’s in which there is low market supply and high market demand. To address this, it is crucial to elucidate the active secondary metabolites and biosynthesis of medicinal orchid secondary metabolites leading towards resource development and utilization.

2. Identification of Secondary Metabolites

These compounds were first proposed by the German chemist Kossel in 1891, and they are small molecules synthesized by organisms in response to environmental stress and resistance. They serve as plant protectants that aid in disease resistance and defense against natural enemies [3][4]. The biological effects of secondary metabolites are the result of species evolution and adaptation to the environment. The secondary metabolites of medicinal orchids can be classified into three groups: terpenoids, phenols and nitrogen compounds, each of which contain tens of thousands of compounds. Furthermore, the production and distribution of these secondary metabolites are species specific and only occur in particular organs, tissues and developmental stages of the orchids [4]. For instance, D. nobile has the largest number of dendrobine types, whereas D. chrysotoxum has the highest content of moscatilin, with stem tissue being the primary medicinal component. The active substances in traditional Chinese medicine are the material basis for their pharmacological effects. Therefore, the identification and analysis of secondary metabolites are necessary prerequisites for the development and application of medicinal orchids’ active substances.

2.1. Alkaloids

Alkaloids are the most commonly found nitrogen-containing compounds in the secondary metabolites of medicinal orchids and an essential source of bioactive compounds. More than 50 species of orchids have yielded the discovery of over 140 alkaloids [5], which can be classified into various groups based on their structural characteristics, such as sesquiterpenes, indolizines, amides and indoles. In 2019, 52 alkaloid components were detected in 19 orchid species [6]. However, the alkaloid content in medicinal orchids is typically low, with only five out of thirty-five Dendrobium plants having an alkaloid content of over 0.1% [7]. This paper summarizes 27 newly identified alkaloids, whose chemistry structure are shown in Figure 1. It is worth noting that three new alkaloids were identified from D. nobile, including a new pair of amide tautomers [8]. Four new indolizine alkaloids were identified from D. crepidatum [9][10]. Furthermore, a pair of enantiomers and three new indolizine alkaloids have been discovered from D. crepidatum [11]. These twenty-seven alkaloids are listed in Table 1 and include eight sesquiterpene alkaloids (1–8), two amides (9–10), eleven indolizines (11–21), four indoles (22–25), a spiral-shaped alkaloid (26) and a Lycodine-type Lycopodium alkaloid (27).
Metabolites 13 00829 g001 550
Figure 1. The chemical structure of alkaloids found in orchids.

2.2. Phenanthrenes

Phenanthrenes are a class of substances with three benzene rings as the parent ring and are commonly found in medicinal orchids. Based on their structural properties, they can be classified into simple phenanthrene, dihydrophenanthrene (DHP), phenanthraquinone (ketone), phenanthrene furan and phenanthrene dimer. Table 1 summarizes the 39 phenanthrenes that were identified from medicinal orchids between 2018 and 2023 (for their chemical structures, refer to Figure 2). Notably, a new DHP trimer was identified from B. striata [12], and silk grass was found to contain six new DHP [13]. Furthermore, monolithic orchids were discovered to have four optically rotating phenanthraquinones [14], and two new phenanthraquinones were found in Dendrobium flowers [15]. Additionally, three secondary metabolites were identified for the first time from plants in the genus Bletilla [12]. These thirty-nine phenanthrenes are listed in Table 1 and include one DHP dimer (28), twenty DHP (29–48), seven simple phenanthrenes (49–55) and nine phenanthraquinones (56–64), as well as furans (65) and biphenanthrene (66).
Metabolites 13 00829 g002 550
Figure 2. The chemical structure of phenanthrene found in orchids.

2.3. Bibenzylates

Bibenzyl is an essential precursor for synthesizing phenanthrene substances, with 1,2-diphenylethane as the parent ring. Among medicinal orchids, the bibenzyls of Dendrobium have been studied in depth. For instance, eight bibenzyl compounds were isolated from D. officinale leaves [16], and its stems contained 15 bibenzyl compounds, including dendrocandin X and 3,4′-dihydroxy-4,5-dimethoxybibenzyl, which were isolated from D. officinale for the first time [17]. Additionally, dendrocandin Y, a new bibenzyl derivative, was discovered from the stem extract [18]. Using UPLC-Q-TOF-MS technology, five bibenzyloids, including densiflorol A, aloifol I and isomoniliformin A, were identified in D. pendulum for the first time [19]. The discovery of new benzyl compounds in medicinal orchids serves as a research resource for developing their medicinal value. Table 1 (67–101) summarizes the information of 35 bibenzyls (for their chemical structures, refer to Figure 3). In Table 1, composition (67) was identified as new from Bletilla, whereas compositions (75, 83, 89) were determined to be new from Dendrobium. Three new substances (90, 98, 101) were found in D. plicatile [20], D. hercoglossum [21] and D. hancockii [22], respectively, within the genus.
Metabolites 13 00829 g003 550
Figure 3. The chemical structure of bibenzyl substances found in orchids.

2.4. Other Secondary Metabolites

Medicinal orchids encompass a wide range of species, each characterized by a diverse array of secondary metabolites. These metabolites can be further categorized into various material types. For instance, flavonoids can be further sub-classified into flavanones, flavonols and other categories. These flavonoids are widely distributed in medicinal orchid plants and are a primary source of plant pigments. In fact, 66 flavonoids have been detected in 24 orchid plants [23], while 34 different species of Dendrobium have been found to contain flavonoids [24], including D. devonianum [25], D. officinale [26][27][28], D. fimbriatum [29] and D. huoshanense [30]. In the family of Orchidaceae, many types of secondary metabolites still exist, and 54 species are summarized in Table 1 (102–155) (for their chemical structures, refer to Figure 4).
Table 1. A total of 155 components were first identified from medicinal orchids in 2018–2023.
NO. Compound Plant Source Reference
Alkaloids
1 Dendrobine C, P [31][32]
2 N-isopentenyl-dendrobinium C, P [31][32]
3 N-isopentenyl-dendroxinium C, P [31][32]
4 诺比洛宁 C， P [31，[32]
5 树蜀葵碱 P [32]
6 穆比罗宁A P [32]
7 芬德莱因· P [32]
8 * 石斛酸 N [8]
9 N-对肉桂酰酪胺 P [32]
10 * N-甲氧基羰基石斛 N [8]
11 克雷皮定 P [32]
12 石斛比利比胺B P [32]
13 石斛红素 P [32]
14 石斛红素C P [32]
15 克雷达明 P [32]
16 石斛酸偶啶D P [32]
17 高顺替啶B P [32]
18 * 克雷替图明 A C [10]
19 * 克雷替坦 B C [10]
20 * Crepidatumines C C [9]
21 * 克雷匹妥胺D C [9]
22 人参皂苷 布，R [33，[33]
23 安诺西托钦 埠 [34]
24 新奇努林A L [35]
25 吲哚-3-醛代 圣 [36]
26# 可口水素A J [37]
27 石杉碱甲 埠 [34]
菲
28 * 2，2′，2“，7，7′，7”-六羟基-4，4′，4“-三甲氧基-[9，9′，9”，10，10′，10“]-六氢-1，8，1′，6”-三菲 圣 [12]
29 2，5-二羟基-4-甲氧基-9，10-二氢菲 PL， M [20，[38]
30 2，5，7-三羟基-4-甲氧基-9，10-二氢菲 B [39]
31 腔肠素 H [40]
32 4，7-二甲氧基-9，10-二氢菲-2-醇 圣 [36]
33 2-甲氧基-9，10-二氢菲-4，5-二醇 圣 [36]
34 4-甲氧基-9，10-二氢菲-1，2，7-三醇 圣 [36]
35 1，4，7-三羟基-2-甲氧基-9，10-二氢菲 .PL [20]
36 卡兰氢醌C .PL [20]
37# 2，7-二羟基-3，5-二甲氧基-9，10-二氢菲 圣 [12]
38# 2，3，7-三羟基-4-甲氧基-9，10-二氢菲 圣 [12]
39 * 螺蒽菲 A 四 [13]
40 * 螺嘟 B 四 [13]
41 * 螺妖菲 C 四 [13]
42 * 螺蝶咽D 四 [13]
43 * 螺嘟嘟 E 四 [13]
44 * 螺孢菲 F 四 [13]
45 石斛红素P1 O [41]
46 石斛红素P2 O [41]
47 * 布莱蒂洛尔 A 圣 [36]
48 金氧托酚A L [35]
49 3，7-二羟基-2，4-二甲氧基菲 .PL [20]
50 2，5-二羟基-4-甲氧基菲 哈， 米 [22，[38]
51 2，5-二羟基-4，9-二甲氧基菲 医 管 局 [22]
52 * 2-hydroxy-3,4,7-trimethoxyphenanthrene O [42]
53 2,4,8-trimethoxy phenanthrene-3,7-diol N [43]
54 5,7-dimethoxyphenanthrene-2,6-diol ST [36]
55 1,5-dimethoxyphenanthrene-2,7-diol ST [36]
56 7-hydroxy-2-methoxy-1,4-phenanthrenequinone HA [22]
57 * Bulbocodioidins A (9R,9S) BUL [14]
58 * Bulbocodioidins B (9R,9S) BUL [14]
59 * Bulbocodioidins C (9R,9S) BUL [14]
60 * Bulbocodioidins D (10S,10R) BUL [14]
61 * 2,3-dimethoxyl-7-hydroxyl-1,4-phenanthrenedione F [15]
62 * 2-methoxyl-3-methyl-7-hydroxyl-9,10-dihydro-1,4-phenanthrenedione F [15]
63 densiflorol B N [43]
64 cypripedin N [43]
65 3-hydroxymethyl-9-methoxy-2-(4′-hydroxy-3′, 5′-dimethoxyphenyl)-2,3,6,7-tetrahydrophenanthro [4, 3-b] furan-5, 11-diol M [38]
66 # 4,7,4′,7′-tetrahydroxy-2,2′-dimethoxy-1,1′-biphenanthrene ST [12]
Bibenzylates
67 # 3-Hydroxy-5-methoxybibenzyl ST [12]
68 3,3′,5-trihydroxybibenzyl L [35]
69 batatasin III L, M, B, H [35][38][39][40]
70 3,4′-dihydroxy-5-methoxybibenzyl H [40]
71 3-hydroxy-4′,5-dimethoxybibenzyl H [40]
72 3-O-methylgigantol H [40]
73 gigantol H [40]
74 3,4-dihydroxy-4′,5-dimethoxybibenzyl H [40]
75 # Moscatilin PL, H [20][40]
76 3,5,5′-trihydroxy-4′-methoxybibenzyl ST [36]
77 3-O-methyldihydropinosylvin ST, M [36][38]
78 Dihydropinosylvin ST [36]
79 3,5,5′-trihydroxybibenzyl ST [36]
80 3,5,4′-trihydroxybibenzyl ST [36]
81 4,3′,5′-trihydroxy-3-methoxybibenzyl HA [22]
82 4,3′-dihydroxy-3,5′-dimethoxybibenzyl HA [22]
83# 3′-hydroxy-3,4,4′,5-tetramethoxybibenzyl PL [20]
84 4,4′-dihydroxy-3,3′,5-trimethoxybibenzyl M, HA [22][38]
85 dendrosinen B B [39]
86 4,3′-dihydroxy-3,5-dimethoxybibenzyl HE [21]
87 4′, 5-dihydroxy-3, 3′-dimethoxybiphezyl B [39]
88 3, 3′-dihydroxy-4, 5-dimethoxybiphezyl B [39]
89 # 3-methylgigantol PL [20]
90 * 2-chloro-3,4′-dihydroxy-3′,5-dimethoxybibenzyl PL [20]
91 4,5-dihydroxy-3,3′,α-trimethoxybibenzyl HE [21]
92 dendrocandin A H [40]
93 (S)-3,4,α-trihydroxy-4′,5-dimethoxybibenzyl H [40]
94 densiflorol A H [40]
95 4,4′-dihydroxyl-3,5-dimethoxylbibenzyl L [35]
96 4,α-dihydroxy-3,5,3′-trimethoxybibenzyl HE [21]
97 dendrosinen D B [39]
98 * 3,4,α-trihydroxy-5,3′-dimethoxybibenzyl HE [21]
99 trigonopol B L [35]
100 4,4′-dihydroxy-3,5,3′-trimethoxybibenzyl HE [21]
101 * 3, α-dihydroxy-4,5,3′-trimethoxybibenzyl HA [22]
Other secondary metabolites    
102 # p-hydroxybenzyl methyl ether ST [12]
103 p-Hydroxybenzyl ether ST [12]
104 p-hydroxybenzyl alcohol ST [12]
105 4-methoxy-phenylethanol S [44]
106 dihydroconiferyl alcohol HU [45]
107 anoectosterol BU, R [33][34]
108 # (E) -4- (2-methoxyvinyl) benzene-1,2-diol N [43]
109 p-hydroxybenzyl alcohol ST [36]
110 3-hydroxybenzaldehyde S [44]
111 3,4-dihydroxy-5-methoxy benzaldehyde HU [45]
112 # 3,5-dihydroxy-4-hydroxy benzaldehyde HU [45]
113 4-hydroxy-3-methoxy benzaldehyde HU [45]
114 5-hydroxymethyl furfural HU [45]
115 coumarin N [43]
116 # moellendorffiline N [43]
117 # isopimpinellin N [43]
118 syringaresinol L, HE [21][35]
119 neoolivil B [39]
120 Matairesinol S [44]
121 # methyl melilotate M [38]
122 # ethyl melilotate M [38]
123 * methyl 2-(acetyloxy) benzenepropanoate M [38]
124 Dihydroconiferyl dihydrop-hydroxycinnamate B [39]
125 eis-p-hydroxyl ethyl cinnamate S [44]
126 p-hydroxyphenylpropionic ethyl ester S [44]
127 methyl 3-(4-hydroxyphenyl) propionate HU [45]
128 (9Z,12Z)-methyl octadeca-9,12-dienoate S [44]
129 hexadecanoic acid 2,3-dihydroxypropyl ester HE [21]
130 p-hydroxyphenyl-propionic acid B [39]
131 p-hydroxybenzoic acid HU [45]
132 p-hydroxycinnamic ac B [39]
133 ferulic acid B [39]
134 caffeic acid B [39]
135 4-Hydroxy-2-methoxy-3,6-dimethylbenzoic acid H [40]
136 # 2-Hydroxy-4-methoxy-3,6-dimethylbenzoic acid B [39]
137 dihydroferulic acid HU [45]
138 # 4-O-β-D-glucopyranosyl coniferyl aldehyde HU [45]
139 4-allyl-2,6-dimethoxyphenyl glucopyranoside HU [45]
140 # 3,4,5-trihydroxyallylbenzene-3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranoside HU [45]
141 (7S,8R)-syringylglycerol-8-O-4′-sinapyl ether 4-O-β-D-glucopyranoside HU [45]
142 # 3,4,5-trimethoxyphenol-1-O-β-D-glucopyranoside HU [45]
143 gastrodin HU [45]
144 (+)-syringaresinol-4-O-β-D-glucopyranoside HU [45]
145 Liriodendrin HU [45]
146 quercetin BU [34]
147 8-p-hydroxybenzyl quercetin BU [34]
148 5,4′-dihydroxy-6,7,3′-trimethoxyflavone BU [34]
149 naringenin L, N, HU [35][43][45]
150 5,4′-dihydroxy-7, 3′, 5′-trimethoxyflavanone L [35]
151 5,7, 4′-trihydroxy-3′, 5′-dimethoxyflavanone L [35]
152 # carthamidin H [40]
153 # periloyrine HU [45]
154 N-trans-cinnamoyltyramine HE [21]
155 # (9Z,11E) -13-hydroxy-9,11-octadecadienoic acid M [38]
Notes: Compounds 1 to 27 are alkaloids, 28 to 66 are phenanthophylls, 67 to 101 are bibenzylls and 102 to 155 are classified as other compounds. * denotes newly identified compounds; # indicates the first isolation from this genus; the rest indicate the first isolation from this plant species. C refers to D. crepidatum, P refers to D. pendulum, N refers to D. nobile, L refers to D. loddigesii, PL refers to D. plicatile, M refers to D. moschatum, H refers to D. heterocarpum, B refers to D. bellatulum, O refers to D. officinale, HA refers to D. hancockii, F refers to Flickingeria fimbriata, HE refers to D. hercoglossum, HU refers to D. huoshanense, S refers to D. sinense, CH refers to D. chrysotoxum, W refers to D. wardianum, BU refers to Anoectochilus burmannicus, R refers to A. roxburghii, ST refers to B. striata, J refers to Liparis japonica, NE refers to L. nervosa, SI refers to Spiranthes sinensis, BUL refers to P. bulbocobioides, Y refers to Pholidota yunnanensis, SU refers to Pecteilis susannae and MI refers to Phaius mishmensis.
Metabolites 13 00829 g004a 550Metabolites 13 00829 g004b 550
Figure 4. The chemical structure of other substances found in orchids.

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Subjects: Plant Sciences; Endocrinology & Metabolism
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Kunqian Li ,
Fengju Wu
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Mengzhu Chen
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Zhihao Xiao
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Ya Xu
,
Mengwei Xu
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Jingyi Liu
, Delin Xu
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Update Date: 24 Jul 2023
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