African Iron Overload

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Yang, C. African Iron Overload. Encyclopedia. Available online: https://encyclopedia.pub/entry/4663 (accessed on 28 September 2026).

Yang C. African Iron Overload. Encyclopedia. Available at: https://encyclopedia.pub/entry/4663. Accessed September 28, 2026.

Yang, Catherine. "African Iron Overload" Encyclopedia, https://encyclopedia.pub/entry/4663 (accessed September 28, 2026).

Yang, C. (2020, December 24). African Iron Overload. In Encyclopedia. https://encyclopedia.pub/entry/4663

Yang, Catherine. "African Iron Overload." Encyclopedia. Web. 24 December, 2020.

African Iron Overload

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/african-iron-overload

African iron overload is a condition that involves absorption of too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the liver, bone marrow, and spleen. Humans cannot increase the excretion of iron, although some iron is lost through bleeding or when cells of the intestine (enterocytes) are shed at the end of the cells' lifespan. Iron levels in the body are primarily regulated through control of how much iron is absorbed from the diet.

genetic conditions

References

Barton JC, Acton RT, Lee PL, West C. SLC40A1 Q248H allele frequencies andQ248H-associated risk of non-HFE iron overload in persons of sub-Saharan African descent. Blood Cells Mol Dis. 2007 Sep-Oct;39(2):206-11.
Beutler E, Barton JC, Felitti VJ, Gelbart T, West C, Lee PL, Waalen J, VulpeC. Ferroportin 1 (SCL40A1) variant associated with iron overload inAfrican-Americans. Blood Cells Mol Dis. 2003 Nov-Dec;31(3):305-9.
Gordeuk VR, Caleffi A, Corradini E, Ferrara F, Jones RA, Castro O, OnyekwereO, Kittles R, Pignatti E, Montosi G, Garuti C, Gangaidzo IT, Gomo ZA, Moyo VM,Rouault TA, MacPhail P, Pietrangelo A. Iron overload in Africans andAfrican-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene.Blood Cells Mol Dis. 2003 Nov-Dec;31(3):299-304.
Gordeuk VR. African iron overload. Semin Hematol. 2002 Oct;39(4):263-9.Review.
McNamara L, Gordeuk VR, MacPhail AP. Ferroportin (Q248H) mutations in African families with dietary iron overload. J Gastroenterol Hepatol. 2005Dec;20(12):1855-8.
Rivers CA, Barton JC, Gordeuk VR, Acton RT, Speechley MR, Snively BM,Leiendecker-Foster C, Press RD, Adams PC, McLaren GD, Dawkins FW, McLaren CE,Reboussin DM. Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron OverloadScreening (HEIRS) Study. Blood Cells Mol Dis. 2007 May-Jun;38(3):247-52.

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Subjects: Genetics & Heredity

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Update Date: 24 Dec 2020

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