WT1 Gene

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Tang, P. WT1 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4627 (accessed on 27 September 2026).

Tang P. WT1 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4627. Accessed September 27, 2026.

Tang, Peter. "WT1 Gene" Encyclopedia, https://encyclopedia.pub/entry/4627 (accessed September 27, 2026).

Tang, P. (2020, December 24). WT1 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4627

Tang, Peter. "WT1 Gene." Encyclopedia. Web. 24 December, 2020.

WT1 Gene

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/wt1

Wilms tumor 1: the WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 protein activity is limited to a structure known as the glomerulus, which filters blood through the kidneys.

genes

References

Al-Hussain T, Ali A, Akhtar M. Wilms tumor: an update. Adv Anat Pathol. 2014May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. Review.
Andrade JG, Guaragna MS, Soardi FC, Guerra-Júnior G, Mello MP, Maciel-GuerraAT. Clinical and genetic findings of five patients with WT1-related disorders.Arq Bras Endocrinol Metabol. 2008 Nov;52(8):1236-43.
Ariyaratana S, Loeb DM. The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis. Expert Rev Mol Med. 2007 May 24;9(14):1-17. Review.
Deng C, Dai R, Li X, Liu F. Genetic variation frequencies in Wilms' tumor: Ameta-analysis and systematic review. Cancer Sci. 2016 May;107(5):690-9. doi:10.1111/cas.12910.
Heathcott RW, Morison IM, Gubler MC, Corbett R, Reeve AE. A review of thephenotypic variation due to the Denys-Drash syndrome-associated germline WT1mutation R362X. Hum Mutat. 2002 Apr;19(4):462. Review.
Miller-Hodges E, Hohenstein P. WT1 in disease: shifting theepithelial-mesenchymal balance. J Pathol. 2012 Jan;226(2):229-40. doi:10.1002/path.2977.
Salvatorelli L, Parenti R, Leone G, Musumeci G, Vasquez E, Magro G. Wilmstumor 1 (WT1) protein: Diagnostic utility in pediatric tumors. Acta Histochem.2015 May-Jun;117(4-5):367-78. doi: 10.1016/j.acthis.2015.03.010.
Suri M, Kelehan P, O'neill D, Vadeyar S, Grant J, Ahmed SF, Tolmie J, McCannE, Lam W, Smith S, Fitzpatrick D, Hastie ND, Reardon W. WT1 mutations in Meacham syndrome suggest a coelomic mesothelial origin of the cardiac and diaphragmaticmalformations. Am J Med Genet A. 2007 Oct 1;143A(19):2312-20.
Yang L, Han Y, Suarez Saiz F, Minden MD. A tumor suppressor and oncogene: the WT1 story. Leukemia. 2007 May;21(5):868-76.Leukemia. 2007 Jul;21(7):1603. Saurez Saiz, F [corrected to Suarez Saiz, F].

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Subjects: Genetics & Heredity

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Update Date: 24 Dec 2020

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