DCTN1 Gene

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Li, V. DCTN1 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4534 (accessed on 22 September 2026).

Li V. DCTN1 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4534. Accessed September 22, 2026.

Li, Vivi. "DCTN1 Gene" Encyclopedia, https://encyclopedia.pub/entry/4534 (accessed September 22, 2026).

Li, V. (2020, December 23). DCTN1 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4534

Li, Vivi. "DCTN1 Gene." Encyclopedia. Web. 23 December, 2020.

DCTN1 Gene

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/dctn1

Dynactin Subunit 1: The DCTN1 gene provides instructions for making a protein called dynactin-1.

genes

References

Farrer MJ, Hulihan MM, Kachergus JM, Dächsel JC, Stoessl AJ, Grantier LL,Calne S, Calne DB, Lechevalier B, Chapon F, Tsuboi Y, Yamada T, Gutmann L, ElibolB, Bhatia KP, Wider C, Vilariño-Güell C, Ross OA, Brown LA, Castanedes-Casey M,Dickson DW, Wszolek ZK. DCTN1 mutations in Perry syndrome. Nat Genet. 2009Feb;41(2):163-5. doi: 10.1038/ng.293.
Levy JR, Sumner CJ, Caviston JP, Tokito MK, Ranganathan S, Ligon LA, WallaceKE, LaMonte BH, Harmison GG, Puls I, Fischbeck KH, Holzbaur EL. A motor neurondisease-associated mutation in p150Glued perturbs dynactin function and inducesprotein aggregation. J Cell Biol. 2006 Feb 27;172(5):733-45.
Münch C, Rosenbohm A, Sperfeld AD, Uttner I, Reske S, Krause BJ, Sedlmeier R, Meyer T, Hanemann CO, Stumm G, Ludolph AC. Heterozygous R1101K mutation of theDCTN1 gene in a family with ALS and FTD. Ann Neurol. 2005 Nov;58(5):777-80.
Münch C, Sedlmeier R, Meyer T, Homberg V, Sperfeld AD, Kurt A, Prudlo J,Peraus G, Hanemann CO, Stumm G, Ludolph AC. Point mutations of the p150 subunitof dynactin (DCTN1) gene in ALS. Neurology. 2004 Aug 24;63(4):724-6.
Puls I, Jonnakuty C, LaMonte BH, Holzbaur EL, Tokito M, Mann E, Floeter MK,Bidus K, Drayna D, Oh SJ, Brown RH Jr, Ludlow CL, Fischbeck KH. Mutant dynactinin motor neuron disease. Nat Genet. 2003 Apr;33(4):455-6.
Puls I, Oh SJ, Sumner CJ, Wallace KE, Floeter MK, Mann EA, Kennedy WR,Wendelschafer-Crabb G, Vortmeyer A, Powers R, Finnegan K, Holzbaur EL, Fischbeck KH, Ludlow CL. Distal spinal and bulbar muscular atrophy caused by dynactinmutation. Ann Neurol. 2005 May;57(5):687-94.
Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:759-79. Review.
Vilariño-Güell C, Wider C, Soto-Ortolaza AI, Cobb SA, Kachergus JM, KeelingBH, Dachsel JC, Hulihan MM, Dickson DW, Wszolek ZK, Uitti RJ, Graff-Radford NR,Boeve BF, Josephs KA, Miller B, Boylan KB, Gwinn K, Adler CH, Aasly JO, HentatiF, Destée A, Krygowska-Wajs A, Chartier-Harlin MC, Ross OA, Rademakers R, Farrer MJ. Characterization of DCTN1 genetic variability in neurodegeneration.Neurology. 2009 Jun 9;72(23):2024-8. doi: 10.1212/WNL.0b013e3181a92c4c.
Wider C, Dachsel JC, Farrer MJ, Dickson DW, Tsuboi Y, Wszolek ZK. Elucidating the genetics and pathology of Perry syndrome. J Neurol Sci. 2010 Feb15;289(1-2):149-54. doi: 10.1016/j.jns.2009.08.044.

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Subjects: Genetics & Heredity

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Update Date: 23 Dec 2020

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