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Xu, C. Lennox-Gastaut Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4511 (accessed on 27 September 2026).
Xu C. Lennox-Gastaut Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4511. Accessed September 27, 2026.
Xu, Camila. "Lennox-Gastaut Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4511 (accessed September 27, 2026).
Xu, C. (2020, December 23). Lennox-Gastaut Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4511
Xu, Camila. "Lennox-Gastaut Syndrome." Encyclopedia. Web. 23 December, 2020.
Lennox-Gastaut Syndrome
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/lennox-gastaut-syndrome

Lennox-Gastaut syndrome is a severe condition characterized by recurrent seizures (epilepsy) that begin early in life.

genetic conditions

References

  1. Arzimanoglou A, French J, Blume WT, Cross JH, Ernst JP, Feucht M, Genton P,Guerrini R, Kluger G, Pellock JM, Perucca E, Wheless JW. Lennox-Gastaut syndrome:a consensus approach on diagnosis, assessment, management, and trial methodology.Lancet Neurol. 2009 Jan;8(1):82-93. doi: 10.1016/S1474-4422(08)70292-8. Review.
  2. Autry AR, Trevathan E, Van Naarden Braun K, Yeargin-Allsopp M. Increased risk of death among children with Lennox-Gastaut syndrome and infantile spasms. JChild Neurol. 2010 Apr;25(4):441-7. doi: 10.1177/0883073809348355.
  3. Camfield PR. Definition and natural history of Lennox-Gastaut syndrome.Epilepsia. 2011 Aug;52 Suppl 5:3-9. doi: 10.1111/j.1528-1167.2011.03177.x.
  4. Cross JH, Auvin S, Falip M, Striano P, Arzimanoglou A. Expert Opinion on theManagement of Lennox-Gastaut Syndrome: Treatment Algorithms and PracticalConsiderations. Front Neurol. 2017 Sep 29;8:505. doi: 10.3389/fneur.2017.00505.
  5. Epi4K Consortium; Epilepsy Phenome/Genome Project, Allen AS, Berkovic SF,Cossette P, Delanty N, Dlugos D, Eichler EE, Epstein MP, Glauser T, Goldstein DB,Han Y, Heinzen EL, Hitomi Y, Howell KB, Johnson MR, Kuzniecky R, Lowenstein DH,Lu YF, Madou MR, Marson AG, Mefford HC, Esmaeeli Nieh S, O'Brien TJ, Ottman R,Petrovski S, Poduri A, Ruzzo EK, Scheffer IE, Sherr EH, Yuskaitis CJ, Abou-KhalilB, Alldredge BK, Bautista JF, Berkovic SF, Boro A, Cascino GD, Consalvo D,Crumrine P, Devinsky O, Dlugos D, Epstein MP, Fiol M, Fountain NB, French J,Friedman D, Geller EB, Glauser T, Glynn S, Haut SR, Hayward J, Helmers SL, Joshi S, Kanner A, Kirsch HE, Knowlton RC, Kossoff EH, Kuperman R, Kuzniecky R,Lowenstein DH, McGuire SM, Motika PV, Novotny EJ, Ottman R, Paolicchi JM, Parent JM, Park K, Poduri A, Scheffer IE, Shellhaas RA, Sherr EH, Shih JJ, Singh R,Sirven J, Smith MC, Sullivan J, Lin Thio L, Venkat A, Vining EP, Von Allmen GK,Weisenberg JL, Widdess-Walsh P, Winawer MR. De novo mutations in epilepticencephalopathies. Nature. 2013 Sep 12;501(7466):217-21. doi: 10.1038/nature12439.
  6. EuroEPINOMICS-RES Consortium; Epilepsy Phenome/Genome Project; Epi4KConsortium. De novo mutations in synaptic transmission genes including DNM1 causeepileptic encephalopathies. Am J Hum Genet. 2014 Oct 2;95(4):360-70. doi:10.1016/j.ajhg.2014.08.013.Jan 5;100(1):179.
  7. Hancock EC, Cross HH. Treatment of Lennox-Gastaut syndrome. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD003277. doi: 10.1002/14651858.CD003277.pub2. Review.Update in: Cochrane Database Syst Rev. 2013;2:CD003277.
  8. Hancock EC, Cross JH. Treatment of Lennox-Gastaut syndrome. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD003277. doi: 10.1002/14651858.CD003277.pub3. Review.
  9. Lund C, Brodtkorb E, Øye AM, Røsby O, Selmer KK. CHD2 mutations inLennox-Gastaut syndrome. Epilepsy Behav. 2014 Apr;33:18-21. doi:10.1016/j.yebeh.2014.02.005.
  10. McTague A, Howell KB, Cross JH, Kurian MA, Scheffer IE. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurol. 2016Mar;15(3):304-16. doi: 10.1016/S1474-4422(15)00250-1.
  11. Nakashima M, Kouga T, Lourenço CM, Shiina M, Goto T, Tsurusaki Y, Miyatake S, Miyake N, Saitsu H, Ogata K, Osaka H, Matsumoto N. De novo DNM1 mutations in two cases of epileptic encephalopathy. Epilepsia. 2016 Jan;57(1):e18-23. doi:10.1111/epi.13257.
  12. Ostendorf AP, Ng YT. Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017 Apr20;13:1131-1140. doi: 10.2147/NDT.S115996.
  13. Selmer KK, Lund C, Brandal K, Undlien DE, Brodtkorb E. SCN1A mutationscreening in adult patients with Lennox-Gastaut syndrome features. EpilepsyBehav. 2009 Nov;16(3):555-7. doi: 10.1016/j.yebeh.2009.08.021.
  14. Terrone G, Bienvenu T, Germanaud D, Barthez-Carpentier MA, Diebold B, Delanoe C, Passemard S, Auvin S. A case of Lennox-Gastaut syndrome in a patient withFOXG1-related disorder. Epilepsia. 2014 Nov;55(11):e116-9. doi:10.1111/epi.12800.
  15. Trevathan E. Infantile spasms and Lennox-Gastaut syndrome. J Child Neurol.2002 Feb;17 Suppl 2:2S9-2S22. Review. Erratum in: J Child Neurol. 2003May;18(5):374.
  16. Zhou P, He N, Zhang JW, Lin ZJ, Wang J, Yan LM, Meng H, Tang B, Li BM, Liu XR,Shi YW, Zhai QX, Yi YH, Liao WP. Novel mutations and phenotypes ofepilepsy-associated genes in epileptic encephalopathies. Genes Brain Behav. 2018 Nov;17(8):e12456. doi: 10.1111/gbb.12456.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Camila Xu
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Entry Collection: MedlinePlus
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Update Date: 23 Dec 2020
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