Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body.
genetic conditions
References
Allen CE, Parsons DW. Biological and clinical significance of somaticmutations in Langerhans cell histiocytosis and related histiocytic neoplasticdisorders. Hematology Am Soc Hematol Educ Program. 2015;2015:559-64. doi:10.1182/asheducation-2015.1.559. Review.
Collin M, Bigley V, McClain KL, Allen CE. Cell(s) of Origin of Langerhans CellHistiocytosis. Hematol Oncol Clin North Am. 2015 Oct;29(5):825-38. doi:10.1016/j.hoc.2015.06.003.
Egeler RM, Katewa S, Leenen PJ, Beverley P, Collin M, Ginhoux F, Arceci RJ,Rollins BJ; Steering Committee of the Nikolas Symposium. Langerhans cellhistiocytosis is a neoplasm and consequently its recurrence is a relapse: Inmemory of Bob Arceci. Pediatr Blood Cancer. 2016 Oct;63(10):1704-12. doi:10.1002/pbc.26104.
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Nelson DS, van Halteren A, Quispel WT, van den Bos C, Bovée JV, Patel B,Badalian-Very G, van Hummelen P, Ducar M, Lin L, MacConaill LE, Egeler RM,Rollins BJ. MAP2K1 and MAP3K1 mutations in Langerhans cell histiocytosis. GenesChromosomes Cancer. 2015 Jun;54(6):361-8. doi: 10.1002/gcc.22247.
Roden AC, Hu X, Kip S, Parrilla Castellar ER, Rumilla KM, Vrana JA, VassalloR, Ryu JH, Yi ES. BRAF V600E expression in Langerhans cell histiocytosis:clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonarycases. Am J Surg Pathol. 2014 Apr;38(4):548-51. doi:10.1097/PAS.0000000000000129.
Rollins BJ. Genomic Alterations in Langerhans Cell Histiocytosis. HematolOncol Clin North Am. 2015 Oct;29(5):839-51. doi: 10.1016/j.hoc.2015.06.004.Review.
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