Laron Syndrome

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Xu, C. Laron Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4477 (accessed on 26 September 2026).

Xu C. Laron Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4477. Accessed September 26, 2026.

Xu, Camila. "Laron Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4477 (accessed September 26, 2026).

Xu, C. (2020, December 23). Laron Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4477

Xu, Camila. "Laron Syndrome." Encyclopedia. Web. 23 December, 2020.

Laron Syndrome

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/laron-syndrome

Laron syndrome is a rare form of short stature that results from the body's inability to use growth hormone, a substance produced by the brain's pituitary gland that helps promote growth.

genetic conditions

References

Amselem S, Duquesnoy P, Attree O, Novelli G, Bousnina S, Postel-Vinay MC,Goossens M. Laron dwarfism and mutations of the growth hormone-receptor gene. NEngl J Med. 1989 Oct 12;321(15):989-95.
Burren CP, Woods KA, Rose SJ, Tauber M, Price DA, Heinrich U, Gilli G,Razzaghy-Azar M, Al-Ashwal A, Crock PA, Rochiccioli P, Yordam N, Ranke MB,Chatelain PG, Preece MA, Rosenfeld RG, Savage MO. Clinical and endocrinecharacteristics in atypical and classical growth hormone insensitivity syndrome. Horm Res. 2001;55(3):125-30.
David A, Hwa V, Metherell LA, Netchine I, Camacho-Hübner C, Clark AJ,Rosenfeld RG, Savage MO. Evidence for a continuum of genetic, phenotypic, andbiochemical abnormalities in children with growth hormone insensitivity. EndocrRev. 2011 Aug;32(4):472-97. doi: 10.1210/er.2010-0023.
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, ChengCW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, LongoVD. Growth hormone receptor deficiency is associated with a major reduction inpro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845.
Guevara-Aguirre J, Rosenbloom AL. Obesity, diabetes and cancer: insight intothe relationship from a cohort with growth hormone receptor deficiency.Diabetologia. 2015 Jan;58(1):37-42. doi: 10.1007/s00125-014-3397-3.
Laron Z. Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003. J Clin Endocrinol Metab. 2004Mar;89(3):1031-44.
Shevah O, Laron Z. Patients with congenital deficiency of IGF-I seem protectedfrom the development of malignancies: a preliminary report. Growth Horm IGF Res. 2007 Feb;17(1):54-7.
Wit JM, Oostdijk W, Losekoot M. Spectrum of insulin-like growth factordeficiency. Endocr Dev. 2012;23:30-41. doi: 10.1159/000341739.Review.

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Subjects: Genetics & Heredity

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Update Date: 23 Dec 2020

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