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Yang, C. ALG6-congenital Disorder of Glycosylation. Encyclopedia. Available online: https://encyclopedia.pub/entry/4356 (accessed on 28 September 2026).
Yang C. ALG6-congenital Disorder of Glycosylation. Encyclopedia. Available at: https://encyclopedia.pub/entry/4356. Accessed September 28, 2026.
Yang, Catherine. "ALG6-congenital Disorder of Glycosylation" Encyclopedia, https://encyclopedia.pub/entry/4356 (accessed September 28, 2026).
Yang, C. (2020, December 23). ALG6-congenital Disorder of Glycosylation. In Encyclopedia. https://encyclopedia.pub/entry/4356
Yang, Catherine. "ALG6-congenital Disorder of Glycosylation." Encyclopedia. Web. 23 December, 2020.
ALG6-congenital Disorder of Glycosylation
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ALG6-congenital disorder of glycosylation (ALG6-CDG, also known as congenital disorder of glycosylation type Ic) is an inherited condition that affects many parts of the body. The signs and symptoms of ALG6-CDG vary widely among people with the condition.

genetic conditions

References

  1. Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M.Gastrointestinal and other clinical manifestations in 17 children with congenitaldisorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr.2004 Mar;38(3):282-7.
  2. Grünewald S, Imbach T, Huijben K, Rubio-Gozalbo ME, Verrips A, de Klerk JB,Stroink H, de Rijk-van Andel JF, Van Hove JL, Wendel U, Matthijs G, Hennet T,Jaeken J, Wevers RA. Clinical and biochemical characteristics of congenitaldisorder of glycosylation type Ic, the first recognized endoplasmic reticulumdefect in N-glycan synthesis. Ann Neurol. 2000 Jun;47(6):776-81.
  3. Imbach T, Burda P, Kuhnert P, Wevers RA, Aebi M, Berger EG, Hennet T. Amutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causescarbohydrate-deficient glycoprotein syndrome type-Ic. Proc Natl Acad Sci U S A.1999 Jun 8;96(12):6982-7.
  4. Imbach T, Grünewald S, Schenk B, Burda P, Schollen E, Wevers RA, Jaeken J, de Klerk JB, Berger EG, Matthijs G, Aebi M, Hennet T. Multi-allelic origin ofcongenital disorder of glycosylation (CDG)-Ic. Hum Genet. 2000 May;106(5):538-45.
  5. Sparks SE, Krasnewich DM. Congenital Disorders of N-Linked Glycosylation andMultiple Pathway Overview. 2005 Aug 15 [updated 2017 Jan 12]. In: Adam MP,Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors.GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle;1993-2020. Available from http://www.ncbi.nlm.nih.gov/books/NBK1332/
  6. Westphal V, Xiao M, Kwok PY, Freeze HH. Identification of a frequent variantin ALG6, the cause of Congenital Disorder of Glycosylation-Ic. Hum Mutat. 2003Nov;22(5):420-1.
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Update Date: 23 Dec 2020
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