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Xu, R. Multicentric Osteolysis, Nodulosis, and Arthropathy. Encyclopedia. Available online: https://encyclopedia.pub/entry/4329 (accessed on 28 September 2026).
Xu R. Multicentric Osteolysis, Nodulosis, and Arthropathy. Encyclopedia. Available at: https://encyclopedia.pub/entry/4329. Accessed September 28, 2026.
Xu, Rita. "Multicentric Osteolysis, Nodulosis, and Arthropathy" Encyclopedia, https://encyclopedia.pub/entry/4329 (accessed September 28, 2026).
Xu, R. (2020, December 23). Multicentric Osteolysis, Nodulosis, and Arthropathy. In Encyclopedia. https://encyclopedia.pub/entry/4329
Xu, Rita. "Multicentric Osteolysis, Nodulosis, and Arthropathy." Encyclopedia. Web. 23 December, 2020.
Multicentric Osteolysis, Nodulosis, and Arthropathy
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/multicentric-osteolysis-nodulosis-and-arthropathy

Multicentric osteolysis, nodulosis, and arthropathy (MONA) describes a rare inherited disease characterized by a loss of bone tissue (osteolysis), particularly in the hands and feet. MONA includes a condition formerly called nodulosis-arthropathy-osteolysis (NAO) syndrome. It may also include a similar disorder called Torg syndrome, although it is unknown whether Torg syndrome is actually part of MONA or a separate disorder caused by a mutation in a different gene.

genetic conditions

References

  1. Al Aqeel A, Al Sewairi W, Edress B, Gorlin RJ, Desnick RJ, Martignetti JA.Inherited multicentric osteolysis with arthritis: a variant resembling Torgsyndrome in a Saudi family. Am J Med Genet. 2000 Jul 3;93(1):11-8.
  2. Al-Mayouf SM, Majeed M, Hugosson C, Bahabri S. New form of idiopathicosteolysis: nodulosis, arthropathy and osteolysis (NAO) syndrome. Am J Med Genet.2000 Jul 3;93(1):5-10. Review.
  3. Castberg FC, Kjaergaard S, Mosig RA, Lobl M, Martignetti C, Martignetti JA,Myrup C, Zak M. Multicentric osteolysis with nodulosis and arthropathy (MONA)with cardiac malformation, mimicking polyarticular juvenile idiopathic arthritis:case report and literature review. Eur J Pediatr. 2013 Dec;172(12):1657-63. doi: 10.1007/s00431-013-2102-8.
  4. Evans BR, Mosig RA, Lobl M, Martignetti CR, Camacho C, Grum-Tokars V,Glucksman MJ, Martignetti JA. Mutation of membrane type-1 metalloproteinase,MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchestersyndrome. Am J Hum Genet. 2012 Sep 7;91(3):572-6. doi:10.1016/j.ajhg.2012.07.022.
  5. Martignetti JA, Aqeel AA, Sewairi WA, Boumah CE, Kambouris M, Mayouf SA, ShethKV, Eid WA, Dowling O, Harris J, Glucksman MJ, Bahabri S, Meyer BF, Desnick RJ.Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentricosteolysis and arthritis syndrome. Nat Genet. 2001 Jul;28(3):261-5.
  6. Rouzier C, Vanatka R, Bannwarth S, Philip N, Coussement A, Paquis-Flucklinger V, Lambert JC. A novel homozygous MMP2 mutation in a family with Winchestersyndrome. Clin Genet. 2006 Mar;69(3):271-6.
  7. Tuysuz B, Mosig R, Altun G, Sancak S, Glucksman MJ, Martignetti JA. A novelmatrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects.Eur J Hum Genet. 2009 May;17(5):565-72. doi: 10.1038/ejhg.2008.204.
  8. Zankl A, Bonafé L, Calcaterra V, Di Rocco M, Superti-Furga A. Winchestersyndrome caused by a homozygous mutation affecting the active site of matrixmetalloproteinase 2. Clin Genet. 2005 Mar;67(3):261-6.
  9. Zankl A, Pachman L, Poznanski A, Bonafé L, Wang F, Shusterman Y, Fishman DA,Superti-Furga A. Torg syndrome is caused by inactivating mutations in MMP2 and isallelic to NAO and Winchester syndrome. J Bone Miner Res. 2007 Feb;22(2):329-33.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Rita Xu
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Entry Collection: MedlinePlus
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Update Date: 23 Dec 2020
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