Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Dean Liu + 337 word(s) 337 2020-12-15 07:58:31

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Liu, D. KLHL3 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4325 (accessed on 29 September 2026).
Liu D. KLHL3 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4325. Accessed September 29, 2026.
Liu, Dean. "KLHL3 Gene" Encyclopedia, https://encyclopedia.pub/entry/4325 (accessed September 29, 2026).
Liu, D. (2020, December 23). KLHL3 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4325
Liu, Dean. "KLHL3 Gene." Encyclopedia. Web. 23 December, 2020.
KLHL3 Gene
Edit

Kelch like family member 3

genes

References

  1. Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A,Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR,Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB,Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, ColeTR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M,Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP.Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyteabnormalities. Nature. 2012 Jan 22;482(7383):98-102. doi: 10.1038/nature10814.
  2. Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N,Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, SoukaseumC, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P,Bagnis CI, Koenig J, Konrad M, Landais P, Mourani C, Niaudet P, Probst V, ThauvinC, Unwin RJ, Soroka SD, Ehret G, Ossowski S, Caulfield M; InternationalConsortium for Blood Pressure (ICBP), Bruneval P, Estivill X, Froguel P,Hadchouel J, Schott JJ, Jeunemaitre X. KLHL3 mutations cause familialhyperkalemic hypertension by impairing ion transport in the distal nephron. NatGenet. 2012 Mar 11;44(4):456-60, S1-3. doi: 10.1038/ng.2218. Erratum in: NatGenet. 2012;44(5):609.
  3. Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 throughdifferent molecular mechanisms. Biochem Biophys Res Commun. 2013 Sep13;439(1):30-4. doi: 10.1016/j.bbrc.2013.08.035.
  4. Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT,Alessi DR, Kurz T. The CUL3-KLHL3 E3 ligase complex mutated in Gordon'shypertension syndrome interacts with and ubiquitylates WNK isoforms:disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.
  5. Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.Proc Natl Acad Sci U S A. 2013 May 7;110(19):7838-43. doi:10.1073/pnas.1304592110.
More
Upload a video for this entry
Information
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Dean Liu
View Times: 669
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 23 Dec 2020
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service