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Xu, R. Mitochondrial Membrane Protein-Associated Neurodegeneration. Encyclopedia. Available online: https://encyclopedia.pub/entry/4230 (accessed on 29 September 2026).
Xu R. Mitochondrial Membrane Protein-Associated Neurodegeneration. Encyclopedia. Available at: https://encyclopedia.pub/entry/4230. Accessed September 29, 2026.
Xu, Rita. "Mitochondrial Membrane Protein-Associated Neurodegeneration" Encyclopedia, https://encyclopedia.pub/entry/4230 (accessed September 29, 2026).
Xu, R. (2020, December 23). Mitochondrial Membrane Protein-Associated Neurodegeneration. In Encyclopedia. https://encyclopedia.pub/entry/4230
Xu, Rita. "Mitochondrial Membrane Protein-Associated Neurodegeneration." Encyclopedia. Web. 23 December, 2020.
Mitochondrial Membrane Protein-Associated Neurodegeneration
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/mitochondrial-membrane-protein-associated-neurodegeneration

Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a disorder of the nervous system. The condition typically begins in childhood or early adulthood and worsens (progresses) over time.

genetic conditions

References

  1. Dogu O, Krebs CE, Kaleagasi H, Demirtas Z, Oksuz N, Walker RH, Paisán-Ruiz C. Rapid disease progression in adult-onset mitochondrial membraneprotein-associated neurodegeneration. Clin Genet. 2013 Oct;84(4):350-5. doi:10.1111/cge.12079.
  2. Gregory A, Hartig M, Prokisch H, Kmiec T, Hogarth P, Hayflick SJ.Mitochondrial Membrane Protein-Associated Neurodegeneration. 2014 Feb 27. In:Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A,editors. GeneReviews® [Internet]. Seattle (WA): University of Washington,Seattle; 1993-2020. Available from http://www.ncbi.nlm.nih.gov/books/NBK185329/
  3. Hartig M, Prokisch H, Meitinger T, Klopstock T. Mitochondrial membraneprotein-associated neurodegeneration (MPAN). Int Rev Neurobiol. 2013;110:73-84.doi: 10.1016/B978-0-12-410502-7.00004-1. Review.
  4. Hartig MB, Iuso A, Haack T, Kmiec T, Jurkiewicz E, Heim K, Roeber S, TarabinV, Dusi S, Krajewska-Walasek M, Jozwiak S, Hempel M, Winkelmann J, Elstner M,Oexle K, Klopstock T, Mueller-Felber W, Gasser T, Trenkwalder C, Tiranti V,Kretzschmar H, Schmitz G, Strom TM, Meitinger T, Prokisch H. Absence of an orphanmitochondrial protein, c19orf12, causes a distinct clinical subtype ofneurodegeneration with brain iron accumulation. Am J Hum Genet. 2011 Oct7;89(4):543-50. doi: 10.1016/j.ajhg.2011.09.007.
  5. Hogarth P, Gregory A, Kruer MC, Sanford L, Wagoner W, Natowicz MR, Egel RT,Subramony SH, Goldman JG, Berry-Kravis E, Foulds NC, Hammans SR, Desguerre I,Rodriguez D, Wilson C, Diedrich A, Green S, Tran H, Reese L, Woltjer RL, HayflickSJ. New NBIA subtype: genetic, clinical, pathologic, and radiographic features ofMPAN. Neurology. 2013 Jan 15;80(3):268-75. doi: 10.1212/WNL.0b013e31827e07be.
  6. Schulte EC, Claussen MC, Jochim A, Haack T, Hartig M, Hempel M, Prokisch H,Haun-Jünger U, Winkelmann J, Hemmer B, Förschler A, Ilg R. Mitochondrial membraneprotein associated neurodegenration: a novel variant of neurodegeneration withbrain iron accumulation. Mov Disord. 2013 Feb;28(2):224-7. doi:10.1002/mds.25256.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Rita Xu
View Times: 620
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 23 Dec 2020
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