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Xu, C. Inherited Thyroxine-Binding Globulin Deficiency. Encyclopedia. Available online: (accessed on 21 June 2024).
Xu C. Inherited Thyroxine-Binding Globulin Deficiency. Encyclopedia. Available at: Accessed June 21, 2024.
Xu, Camila. "Inherited Thyroxine-Binding Globulin Deficiency" Encyclopedia, (accessed June 21, 2024).
Xu, C. (2020, December 23). Inherited Thyroxine-Binding Globulin Deficiency. In Encyclopedia.
Xu, Camila. "Inherited Thyroxine-Binding Globulin Deficiency." Encyclopedia. Web. 23 December, 2020.
Inherited Thyroxine-Binding Globulin Deficiency

Inherited thyroxine-binding globulin deficiency is a genetic condition that typically does not cause any health problems. Thyroxine-binding globulin is a protein that carries hormones made or used by the thyroid gland, which is a butterfly-shaped tissue in the lower neck.

genetic conditions

1. Introduction

Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). Most of the time, these hormones circulate in the bloodstream attached to thyroxine-binding globulin and similar proteins. If there is a shortage (deficiency) of thyroxine-binding globulin, the amount of circulating thyroid hormones is reduced.

Researchers have identified two forms of inherited thyroxine-binding globulin deficiency: the complete form (TBG-CD), which results in a total loss of thyroxine-binding globulin, and the partial form (TBG-PD), which reduces the amount of this protein or alters its structure. Neither of these conditions causes any problems with thyroid function. They are usually identified during routine blood tests that measure thyroid hormones.

Although inherited thyroxine-binding globulin deficiency does not cause any health problems, it can be mistaken for more serious thyroid disorders (such as hypothyroidism). Therefore, it is important to diagnose inherited thyroxine-binding globulin deficiency to avoid unnecessary treatments.

2. Frequency

The complete form of inherited thyroxine-binding globulin deficiency, TBG-CD, affects about 1 in 15,000 newborns worldwide. The partial form, TBG-PD, affects about 1 in 4,000 newborns. These conditions appear to be more common in the Indigenous (native) population of Australia and in the Bedouin population of southern Israel.

3. Causes

Inherited thyroxine-binding globulin deficiency results from mutations in the SERPINA7 gene. This gene provides instructions for making thyroxine-binding globulin. Some mutations in the SERPINA7 gene prevent the production of a functional protein, causing TBG-CD. Other mutations reduce the amount of this protein or alter its structure, resulting in TBG-PD.

Researchers have also described non-inherited forms of thyroxine-binding globulin deficiency, which are more common than the inherited form. Non-inherited thyroxine-binding globulin deficiency can occur with a variety of illnesses and is a side effect of some medications.

4. Inheritance

Inherited thyroxine-binding globulin deficiency has an X-linked pattern of inheritance. The SERPINA7 gene is located on the X chromosome, which is one of the two sex chromosomes.

In males (who have only one X chromosome), a mutation in the only copy of the gene in each cell causes partial or complete inherited thyroxine-binding globulin deficiency. In females (who have two X chromosomes), a mutation in one of the two copies of the gene in each cell reduces the amount of thyroxine-binding globulin. However, their levels of this protein are usually within the normal range.

A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.

5. Other Names for This Condition

  • TBG



  1. Knobel M, Medeiros-Neto G. An outline of inherited disorders of the thyroidhormone generating system. Thyroid. 2003 Aug;13(8):771-801. Review.
  2. Okamoto H, Mori Y, Tani Y, Nakagomi Y, Sano T, Ohyama K, Saito H, Oiso Y.Molecular analysis of females manifesting thyroxine-binding globulin (TBG)deficiency: selective X-chromosome inactivation responsible for the differencebetween phenotype and genotype in TBG-deficient females. J Clin Endocrinol Metab.1996 Jun;81(6):2204-8.
  3. Schussler GC. The thyroxine-binding proteins. Thyroid. 2000 Feb;10(2):141-9.Review. Erratum in: Thyroid 2000 Apr;10(4):372.
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