Isolated Sulfite Oxidase Deficiency

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/isolated-sulfite-oxidase-deficiency

Isolated sulfite oxidase deficiency (ISOD) is a disorder of the nervous system, with a severe "classic" form that starts in the newborn period and a milder, late-onset form that begins later in infancy or early childhood.

genetic conditions

1. Introduction

Classic ISOD appears within the first few days after birth with signs and symptoms of brain dysfunction (encephalopathy) that quickly get worse. Babies with classic ISOD have seizures that are difficult to treat and feeding difficulties. They have muscle stiffness that results in paralysis of the arms and legs (spastic quadriplegia) and episodes of muscle spasms that cause backward arching of the spine (opisthotonus). Because development of the brain is impaired, the head does not grow at the same rate as the body, so it appears that the head is getting smaller as the body grows (progressive microcephaly). Abnormalities in facial features also become increasingly pronounced with lack of normal head growth. These facial differences include a relatively long and narrow face; deep-set, widely-spaced eyes; elongated openings of the eyes (palpebral fissures); puffy cheeks; a small nose; a large space between the nose and upper lip (a long philtrum); and thick lips.

Babies with classic ISOD do not respond to their environment except to startle easily in response to noises, and they do not develop any motor skills such as turning over or sitting up. They usually do not live for more than a few months. Affected individuals who survive past infancy usually develop displacement of the lenses of the eyes (ectopia lentis). Because these individuals do not react to visual stimuli (are behaviorally blind) due to the brain damage associated with classic ISOD, the ectopia lentis has no further impact on their vision.

Late-onset ISOD usually begins between the ages of 6 and 18 months, often after an illness involving fever. Individuals with this form of the disorder may not have the seizures and ectopia lentis that usually occur in the classic form. They have developmental delay and may lose skills that they had already developed (developmental regression). Movement problems occur in this form of the disorder, including muscle tensing (dystonia), uncontrolled movements of the limbs (choreoathetosis), and difficulty with coordination (ataxia). The signs and symptoms of late-onset ISOD can gradually get worse (progress), or they can be episodic, which means that they come and go. Some individuals with this form of ISOD survive into childhood or adolescence; because of the rarity of this disorder, their life expectancy is unknown.

2. Frequency

The prevalence of ISOD is unknown. At least 50 affected individuals have been described in the medical literature.

3. Causes

ISOD is caused by mutations in the SUOX gene. This gene provides instructions for making an enzyme called sulfite oxidase, which helps break down protein building blocks (amino acids) that contain sulfur when they are no longer needed. Specifically, sulfite oxidase is involved in the final step of this process, in which sulfur-containing molecules called sulfites are converted to other molecules called sulfates by adding an oxygen atom (a process called oxidation).

The SUOX gene mutations that cause ISOD impair the function of sulfite oxidase, preventing complete breakdown of sulfur-containing amino acids. As a result, sulfites and other compounds left over from the partial breakdown process abnormally accumulate in the body. Researchers suggest that the nervous system is especially sensitive to this abnormal accumulation, and excessive levels of sulfite compounds that are toxic to the brain are thought to result in the brain damage that occurs in ISOD. It is unclear why most affected individuals have the classic form of the condition while a smaller number develop the milder late-onset form.

4. Inheritance

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

5. Other Names for This Condition

encephalopathy due to sulfite oxidase deficiency
ISOD
sulfocysteinuria

References

Bindu PS, Christopher R, Mahadevan A, Bharath RD. Clinical and imagingobservations in isolated sulfite oxidase deficiency. J Child Neurol. 2011Aug;26(8):1036-40. doi: 10.1177/0883073811401399.
Bosley TM, Alorainy IA, Oystreck DT, Hellani AM, Seidahmed MZ, Osman Mel F,Sabry MA, Rashed MS, Al-Yamani EA, Abu-Amero KK, Salih MA. Neurologic injury inisolated sulfite oxidase deficiency. Can J Neurol Sci. 2014 Jan;41(1):42-8.
Claerhout H, Witters P, Régal L, Jansen K, Van Hoestenberghe MR, Breckpot J,Vermeersch P. Isolated sulfite oxidase deficiency. J Inherit Metab Dis. 2018Jan;41(1):101-108. doi: 10.1007/s10545-017-0089-4.
Karakas E, Kisker C. Structural analysis of missense mutations causingisolated sulfite oxidase deficiency. Dalton Trans. 2005 Nov 7;(21):3459-63.
Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C. Structural insights into sulfite oxidase deficiency. J Biol Chem. 2005 Sep 30;280(39):33506-15.
Rocha S, Ferreira AC, Dias AI, Vieira JP, Sequeira S. Sulfite oxidasedeficiency--an unusual late and mild presentation. Brain Dev. 2014Feb;36(2):176-9. doi: 10.1016/j.braindev.2013.01.013.
Sass JO, Gunduz A, Araujo Rodrigues Funayama C, Korkmaz B, Dantas Pinto KG,Tuysuz B, Yanasse Dos Santos L, Taskiran E, de Fátima Turcato M, Lam CW, Reiss J,Walter M, Yalcinkaya C, Camelo Junior JS. Functional deficiencies of sulfiteoxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia. Brain Dev. 2010 Aug;32(7):544-9. doi:10.1016/j.braindev.2009.09.005.
Tan WH, Eichler FS, Hoda S, Lee MS, Baris H, Hanley CA, Grant PE,Krishnamoorthy KS, Shih VE. Isolated sulfite oxidase deficiency: a case reportwith a novel mutation and review of the literature. Pediatrics. 2005Sep;116(3):757-66. Review. Erratum in: Pediatrics. 2005 Dec;116(6):1615.
Touati G, Rusthoven E, Depondt E, Dorche C, Duran M, Heron B, Rabier D, Russo M, Saudubray JM. Dietary therapy in two patients with a mild form of sulphiteoxidase deficiency. Evidence for clinical and biological improvement. J InheritMetab Dis. 2000 Feb;23(1):45-53.
Zaki MS, Selim L, El-Bassyouni HT, Issa MY, Mahmoud I, Ismail S, Girgis M,Sadek AA, Gleeson JG, Abdel Hamid MS. Molybdenum cofactor and isolated sulphiteoxidase deficiencies: Clinical and molecular spectrum among Egyptian patients.Eur J Paediatr Neurol. 2016 Sep;20(5):714-22. doi: 10.1016/j.ejpn.2016.05.011.

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Camila Xu

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Table of Contents

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1. Introduction

2. Frequency

3. Causes

4. Inheritance

5. Other Names for This Condition

References

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1. Introduction

2. Frequency

3. Causes

3.1. The gene associated with Isolated sulfite oxidase deficiency

4. Inheritance

5. Other Names for This Condition

References