Hutchinson-Gilford Progeria Syndrome

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Xu, C. Hutchinson-Gilford Progeria Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4126 (accessed on 25 September 2026).

Xu C. Hutchinson-Gilford Progeria Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4126. Accessed September 25, 2026.

Xu, Camila. "Hutchinson-Gilford Progeria Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4126 (accessed September 25, 2026).

Xu, C. (2020, December 23). Hutchinson-Gilford Progeria Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4126

Xu, Camila. "Hutchinson-Gilford Progeria Syndrome." Encyclopedia. Web. 23 December, 2020.

Hutchinson-Gilford Progeria Syndrome

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/hutchinson-gilford-progeria-syndrome

Hutchinson-Gilford progeria syndrome is a genetic condition characterized by the dramatic, rapid appearance of aging beginning in childhood.

genetic conditions

References

De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I,Lyonnet S, Stewart CL, Munnich A, Le Merrer M, Lévy N. Lamin a truncation inHutchinson-Gilford progeria. Science. 2003 Jun 27;300(5628):2055.
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR,Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Recurrent de novo point mutations in lamin A causeHutchinson-Gilford progeria syndrome. Nature. 2003 May 15;423(6937):293-8.
Ghosh S, Zhou Z. Genetics of aging, progeria and lamin disorders. Curr OpinGenet Dev. 2014 Jun;26:41-6. doi: 10.1016/j.gde.2014.05.003.Review.
Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB,Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. Accumulation of mutant laminA causes progressive changes in nuclear architecture in Hutchinson-Gilfordprogeria syndrome. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8963-8.
Gonzalez JM, Pla D, Perez-Sala D, Andres V. A-type lamins andHutchinson-Gilford progeria syndrome: pathogenesis and therapy. Front Biosci(Schol Ed). 2011 Jun 1;3:1133-46. Review.
Gordon LB, Brown WT, Collins FS. Hutchinson-Gilford Progeria Syndrome. 2003Dec 12 [updated 2019 Jan 17]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE,Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK1121/
Halaschek-Wiener J, Brooks-Wilson A. Progeria of stem cells: stem cellexhaustion in Hutchinson-Gilford progeria syndrome. J Gerontol A Biol Sci MedSci. 2007 Jan;62(1):3-8. Review.
Hennekam RC. Hutchinson-Gilford progeria syndrome: review of the phenotype. AmJ Med Genet A. 2006 Dec 1;140(23):2603-24. Review.
Pollex RL, Hegele RA. Hutchinson-Gilford progeria syndrome. Clin Genet. 2004Nov;66(5):375-81. Review.

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Subjects: Genetics & Heredity

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Update Date: 23 Dec 2020

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