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Moe, S.R.;  Haukeland, H.;  Molberg, �.;  Lerang, K. Outcome in Systemic Lupus Erythematosus. Encyclopedia. Available online: https://encyclopedia.pub/entry/41092 (accessed on 01 December 2024).
Moe SR,  Haukeland H,  Molberg �,  Lerang K. Outcome in Systemic Lupus Erythematosus. Encyclopedia. Available at: https://encyclopedia.pub/entry/41092. Accessed December 01, 2024.
Moe, Sigrid Reppe, Hilde Haukeland, Øyvind Molberg, Karoline Lerang. "Outcome in Systemic Lupus Erythematosus" Encyclopedia, https://encyclopedia.pub/entry/41092 (accessed December 01, 2024).
Moe, S.R.,  Haukeland, H.,  Molberg, �., & Lerang, K. (2023, February 10). Outcome in Systemic Lupus Erythematosus. In Encyclopedia. https://encyclopedia.pub/entry/41092
Moe, Sigrid Reppe, et al. "Outcome in Systemic Lupus Erythematosus." Encyclopedia. Web. 10 February, 2023.
Outcome in Systemic Lupus Erythematosus
Edit

Systemic Lupus Erythematosus (SLE) is a rare systemic and chronic disease often referred to as the prototype of autoimmune rheumatic diseases because of the varied spectrum of clinical manifestations and diversity of phenotypes. The etiology of SLE is believed to be multifactorial, and both genetic predisposition and environmental triggers are most likely involved. The incidence, severity and phenotypic expression of the disease differ between ethnic groups, gender and age at disease onset.

epidemiology Systemic Lupus Erythematosus outcome mortality survival end-stage renal disease cancer

1. Introduction

Systemic Lupus Erythematosus (SLE) is a rare systemic and chronic disease often referred to as the prototype of autoimmune rheumatic diseases because of the varied spectrum of clinical manifestations and diversity of phenotypes. The etiology of SLE is believed to be multifactorial, and both genetic predisposition and environmental triggers are most likely involved [1]. The incidence, severity and phenotypic expression of the disease differ between ethnic groups, gender and age at disease onset. The annual incidence of SLE varies from 0.3 to 23.3/100,000, and the prevalence varies from 0 to 241/100,000 [1]. The variations are highly dependent on the method of retrieval and the definition of SLE diagnosis.

Several aspects of SLE make it one of the most challenging conditions to study at the population level. First, no diagnostic criteria for SLE exist and the diagnosis is based on the judgement of an experienced clinician. Diagnosing SLE can be challenging since SLE is a great imitator of other diseases. The symptoms of SLE overlap many other diseases that can easily be mistaken for SLE in as much as 40% [2][3][4][5] of cases.

Secondly, in many countries, SLE patients are not treated in the same hospital and/or specialization since different organs may be affected and the severity of the disease varies. Selected patient populations from tertiary hospitals tend to miss milder cases, and therefore underestimate the incidence and overestimate the severity of SLE. Thus, a closer estimate of the true frequency of clinical and laboratory SLE manifestations and outcomes is more likely from a geographically complete cohort of patients. All these aspects of the disease make it difficult and labour-intensive to collect epidemiological data. In Georgia, Lim et al. found 45,000 potential patients, screened 3142 records and found 1320 patients with a verified SLE diagnosis. In Sweden, Ingvarsson et al. screened 2461 cases and found 55 patients with a verified diagnosis, and Voss et al. in Denmark screened 980 cases to find 95 patients with a verified SLE diagnosis [4][5][6].

Earlier publications on SLE and epidemiology differ greatly in study-design. A good epidemiological study is highly dependent on valid data to obtain reliable results that are indicative of the total size of the problem and thus, a reliable assessment of outcome. Truly population-based research, with a verified and ascertained SLE diagnosis by chart review, is the best way to achieve the most accurate knowledge possible on this disease and its outcome measures. The use of standardized methods gives the best basis for comparison of epidemiological data across different studies and countries.

2. Related Research

A senior medical librarian searched two electronic databases: MEDLINE (Ovid) and Embase (Ovid), from their inception to 25 June 2021, with language restricted to English. The systematic search used both controlled vocabulary (MeSH terms or EMTREE terms) and text word search in title, abstract or author keywords. The search consisted of two searches with different approaches. Search 1: Concepts for systemic lupus, SLE criteria, mortality or cancer, were combined with the Boolean operator AND. Search 2: Concepts for lupus nephritis, end stage renal disease or kidney transplantation were combined with the Boolean operator AND ( Supplementary Materials S2 ). Both searches were restricted to population-based cohorts.

Two investigators (HH and KL or SRM and KL) independently evaluated all abstracts and titles to determine eligibility for inclusion. When necessary, the articles were reviewed in full, and, if in conflict, discussed in plenum (HH, SRM, KL). The authors also searched the reference list of included articles to find additional relevant studies.

For inclusion, the SLE diagnosis had to be verified by chart review. Studies on SLE were included on the relevant outcomes: mortality, overall and renal survival and risk of malignancy.

Researchers excluded: (1) Studies that failed to validate the SLE diagnosis by chart review; (2) Studies based on administrative data; (3) Studies from tertiary centers only, if it was not specified that it was the only hospital serving the region; (4) Animal studies; (5) Meta-analysis; (6) Case reports; (7) Studies on unrelated outcomes; (8) Studies of selected SLE subsets (paediatric SLE, biopsy-proven lupus nephritis (LN), hospital inpatients); (9) Studies with fewer than 30 patients; (10) Studies on subset of relevant outcome (cardiovascular mortality).

3. Compared Research of Systemic Lupus Erythematosus

A control group is necessary to enhance the quality of survival estimates in SLE. As survival from SLE improves, it may become similar to the survival rate in the general population. The reported survival rate from studies depends on the age composition of the SLE cohort and hence, the time since inception. Nine of the studies included made use of a control group in their survival analysis. They all included only incident cases and five studies were also defined as inception studies. From the inception studies with control groups conducted after 1990, the ten-year survival is only slightly lower in the SLE groups versus the control groups (91% vs. 96%) [7][8]. However, the gap seems to increase with time from diagnosis [9][10].

Researchers identified only three studies on cancer development in SLE patients. Only one was an inception study [11]. In these studies, the cancer risk was increased by 1.2–1.8 times. By comparison, a prior review, which also included non-population-based studies, found an increased risk of cancer ranging from 1.1 to 3.6 times in the SLE population [12]. The lowest cancer risk (SMR 1.2) found was from an old Swedish study with 116 SLE patients. The study from the National Health Insurance Research Database from Taiwan is on the other end of the scale, with a SIR of 1.8 [13].

Considerable differences in the methods for case finding, verification of diagnosis, and study design can make comparing the results of the SLE outcomes difficult. To overcome some of these problems, all studies have employed comprehensive case-finding and case ascertainment methods, or it has been indicated in the article that all patients in a defined geographic region were included. However, the geographic area and its location for care of SLE patients is not always described in detail, and it is likely that researchers have missed some population-based studies.

The composition of the cohorts used for analysis of outcomes differs as some studies include all patients and some include only incident patients, making comparisons more difficult. Only seven studies of incident SLE patients had a follow-up period over 15 years [9][10][11][14][15][16][17]. The reason for this may be that hospital data registries going back before the year 2000 are rare and not so easily accessible. They may also not contain the entire volume of ICD-codes on outpatients [18].

4. Conclusions

Population-based studies on SLE patients with a verified diagnosis is considered the gold standard in the pursuit of finding the true outcomes of suffering from SLE. Studies using the 1997 ACR criteria are easier to compare over time, as most studies included only SLE patients with four or more ACR criteria. There is a special need for cancer studies and studies with longer follow-up time on survival in population-based inception cohorts.

References

  1. Rees, F.; Doherty, M.; Grainge, M.; Lanyon, P.; Zhang, W. The worldwide incidence and prevalence of systemic lupus erythematosus: A systematic review of epidemiological studies. Rheumatology 2017, 56, 1945–1961.
  2. Lerang, K.; Gilboe, I.-M.; Gran, J.T. Differences between rheumatologists and other internists regarding diagnosis and treatment of systemic lupus erythematosus. Rheumatology 2011, 51, 663–669.
  3. Gergianaki, I.; Fanouriakis, A.; Repa, A.; Tzanakakis, M.; Adamichou, C.; Pompieri, A.; Spirou, G.; Bertsias, A.; Kabouraki, E.; Tzanakis, I.; et al. Epidemiology and burden of systemic lupus erythematosus in a Southern European population: Data from the community-based lupus registry of Crete, Greece. Ann. Rheum. Dis. 2017, 76, 1992–2000.
  4. Voss, A.; Green, A.; Junker, P. Systemic lupus erythematosus in Denmark: Clinical and epidemiological characterization of a county-based cohort. Scand. J. Rheumatol. 1998, 27, 98–105.
  5. Ingvarsson, R.F.; Bengtsson, A.A.; Jönsen, A. Variations in the epidemiology of systemic lupus erythematosus in southern Sweden. Lupus 2016, 25, 772–780.
  6. Lim, S.S.; Bayakly, A.R.; Helmick, C.G.; Gordon, C.; Easley, K.; Drenkard, C. The Incidence and Prevalence of Systemic Lupus Erythematosus, 2002–2004: The Georgia Lupus Registry. Arthritis Rheumatol. 2013, 66, 357–368.
  7. Eilertsen, G.; Becker-Merok, A.; Nossent, J.C. The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus: Epidemiology, Disease Presentation, and Patient Management. J. Rheumatol. 2009, 36, 552–559.
  8. Lerang, K.; Gilboe, I.-M.; Thelle, D.S.; Gran, J.T. Mortality and years of potential life loss in systemic lupus erythematosus: A population-based cohort study. Lupus 2014, 23, 1546–1552.
  9. Ingvarsson, R.F.; Landgren, A.J.; Bengtsson, A.A.; Jönsen, A. Good survival rates in systemic lupus erythematosus in southern Sweden, while the mortality rate remains increased compared with the population. Lupus 2019, 28, 1488–1494.
  10. Alonso, M.D.; Llorca, J.; Martinez-Vazquez, F.; Miranda-Filloy, J.A.; de Teran, T.D.; Dierssen, T.; Rodriguez, T.R.V.; Gomez-Acebo, I.; Blanco, R.; Gonzalez-Gay, M.A. Systemic Lupus Erythematosus in Northwestern Spain. Medicine 2011, 90, 350–358.
  11. Nived, O.; Bengtsson, A.; Jönsen, A.; Sturfelt, G.; Olsson, H. Malignancies during follow-up in an epidemiologically defined systemic lupus erythematosus inception cohort in southern Sweden. Lupus 2001, 10, 500–504.
  12. Choi, M.Y.; Flood, K.; Bernatsky, S.; Ramsey-Goldman, R.; Clarke, A.E. A review on SLE and malignancy. Best Pr. Res. Clin. Rheumatol. 2017, 31, 373–396.
  13. Chen, Y.-J.; Chang, Y.-T.; Wang, C.-B.; Wu, C.-Y. Malignancy in Systemic Lupus Erythematosus: A Nationwide Cohort Study in Taiwan. Am. J. Med. 2010, 123, 1150.e1–1150.e6.
  14. Peschken, C.A.; Esdaile, J.M. Systemic lupus erythematosus in North American Indians: A population based study. J. Rheumatol. 2000, 27.
  15. Mok, C.C.; Mak, A.; Chu, W.P.; To, C.H.; Nin Wong, S. Long-term Survival of Southern Chinese Patients With Systemic Lupus Erythematosus. Medicine 2005, 84, 218–224.
  16. Bartels, C.M.; Buhr, K.A.; Goldberg, J.W.; Bell, C.L.; Visekruna, M.; Nekkanti, S.; Greenlee, R.T. Mortality and Cardiovascular Burden of Systemic Lupus Erythematosus in a US Population-based Cohort. J. Rheumatol. 2014, 41, 680–687.
  17. Jarukitsopa, S.; Hoganson, D.D.; Crowson, C.S.; Sokumbi, O.; Davis, M.D.; Michet, C.J.; Matteson, E.L.; Kremers, H.M.; Chowdhary, V.R. Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States. Arthritis Rheum. 2014, 67, 817–828.
  18. Jørgensen, K.T.; Pedersen, B.V.; Nielsen, N.M.; Jacobsen, S.; Frisch, M. Childbirths and risk of female predominant and other autoimmune diseases in a population-based Danish cohort. J. Autoimmun. 2012, 38, J81–J87.
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